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    Results: 12

    1.
    Full record GDS3232

    Brain response to human and chimpanzee diets

    Analysis of brains from NMR1 females fed human and chimpanzee diets for 2 weeks. The human diet is markedly different from the diets of closely related primate species. Results provide insight into the influence of different diets on gene expression patterns in brain.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, transformed count, 4 protocol sets
    Platform:
    GPL1261
    Series:
    GSE6285
    24 Samples
    Download data:
    GEO (CEL)
    2.

    Expression data from livers of mice fed four different diets

    (Submitter supplied) Beyond the DNA sequence difference between humans and closely related apes, there are large differences in the environments that these species experience. One prominent example for this is diet. The human diet diverges from those of other primates in various aspects, such as having a high calorie and protein content, as well as being cooked. Here, we used a laboratory mouse model to identify gene expression differences related to dietary differences. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Dataset:
    GDS3221
    Platform:
    GPL1261
    24 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE6297
    ID:
    200006297
    3.

    Expression data from brains of mice fed four different diets

    (Submitter supplied) Beyond the DNA sequence difference between humans and closely related apes, there are large differences in the environments that these species experience. One prominent example for this is diet. The human diet diverges from those of other primates in various aspects, such as having a high calorie and protein content, as well as being cooked. Here, we used a laboratory mouse model to identify gene expression differences related to dietary differences. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Dataset:
    GDS3232
    Platform:
    GPL1261
    24 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE6285
    ID:
    200006285
    4.
    Full record GDS3221

    Liver response to human and chimpanzee diets

    Analysis of livers from NMR-1 females fed human and chimpanzee diets for 2 weeks. Human diet is markedly different from the diets of closely related primate species. Results provide insight into the influence of different diets on gene expression patterns.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, transformed count, 4 protocol sets
    Platform:
    GPL1261
    Series:
    GSE6297
    24 Samples
    Download data:
    GEO (CEL)
    5.

    Evolutionary Significance of DNA Methylation in Human and Chimpanzee Brains

    (Submitter supplied) We compared the genome-wide patterns of DNA methylation in the brains of humans to those of our closest evolutionary relative, chimpanzees, using base-pair resolution whole-genome methylation maps of the prefrontal cortex. Our data reveal that the prefrontal cortex is the most heavily methylated among the human tissues examined so far. Nevertheless, hundreds of genes exhibit dramatically reduced levels of promoter DNA methylation in the human brain relative to the chimpanzee brain. more...
    Organism:
    Homo sapiens; Pan troglodytes
    Type:
    Methylation profiling by high throughput sequencing
    Platforms:
    GPL15434 GPL9115 GPL15433
    6 Samples
    Download data:
    GEO (GFF), SRA SRP012161
    Series
    Accession:
    GSE37202
    ID:
    200037202
    6.

    Human-specific patterns of gene expression in the brain

    (Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
    Organism:
    Pan troglodytes; Macaca mulatta; Homo sapiens
    Type:
    Expression profiling by array; Expression profiling by high throughput sequencing
    5 related Platforms
    92 Samples
    Download data:
    GEO (CEL, TXT)
    Series
    Accession:
    GSE33588
    ID:
    200033588
    7.

    Human-specific patterns of gene expression in the brain (RNA-Seq)

    (Submitter supplied) We identified human-specific gene expression patterns in the brain by comparing expression with chimpanzee and rhesus macaque.
    Organism:
    Macaca mulatta; Homo sapiens; Pan troglodytes
    Type:
    Expression profiling by high throughput sequencing
    Platforms:
    GPL9378 GPL9115 GPL9160
    44 Samples
    Download data:
    GEO (TXT), SRA SRP009247
    Series
    Accession:
    GSE33587
    ID:
    200033587
    8.

    Human-specific patterns of gene expression in the brain (Arrays)

    (Submitter supplied) We identified human-specific gene expression patterns in the brain by comparing expression with chimpanzee and rhesus macaque
    Organism:
    Macaca mulatta; Homo sapiens; Pan troglodytes
    Type:
    Expression profiling by array
    Platforms:
    GPL570 GPL3535
    48 Samples
    Download data:
    GEO (CEL, TXT)
    Series
    Accession:
    GSE33010
    ID:
    200033010
    9.

    A Genome-wide Study of DNA Methylation Patterns and Gene Expression Levels in Multiple Human and Chimpanzee Tissues

    (Submitter supplied) It has long been hypothesized that changes in gene regulation have played an important role in primate evolution. However, despite the wealth of comparative gene expression data, there are still only few studies that focus on the mechanisms underlying inter-primate differences in gene regulation. In particular, we know relatively little about the degree to which changes in epigenetic profiles might explain differences in gene expression levels between primates. more...
    Organism:
    Pan troglodytes; Homo sapiens
    Type:
    Methylation profiling by array
    Platform:
    GPL8490
    71 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE26033
    ID:
    200026033
    10.

    Gene expression analysis of the human and chimpanzee brain

    (Submitter supplied) The origin of humans was accompanied by the emergence of new behavioral and cognitive functions, including language and specialized forms of abstract representation. However, the molecular foundations of these human capabilities are poorly understood. Because of the extensive similarity between human and chimpanzee DNA sequences, it has been suggested that many of the key phenotypic differences between species result primarily from alterations in the regulation of genes rather than in their sequences. more...
    Organism:
    Pan troglodytes; Homo sapiens
    Type:
    Expression profiling by array
    Dataset:
    GDS2678
    Platform:
    GPL8300
    37 Samples
    Download data:
    GEO (CEL, CHP, EXP)
    Series
    Accession:
    GSE7540
    ID:
    200007540
    11.
    Full record GDS2678

    Brain regions of humans and chimpanzees

    Comparison of various human and chimpanzee brain regions. Results provide insight into the genetic basis of human specializations in brain organization and cognition.
    Organism:
    Pan troglodytes; Homo sapiens
    Type:
    Expression profiling by array, count, 2 species, 12 tissue sets
    Platform:
    GPL8300
    Series:
    GSE7540
    37 Samples
    Download data:
    GEO (CEL, CHP, EXP)
    12.

    Large-scale multi-species survey of metabolome and lipidome

    (Submitter supplied) This dataset was generated with the goal of comparative study of gene expression in three brain regions and two non-neural tissues of humans, chimpanzees, macaque monkeys and mice. Using this dataset, we performed studies of gene expression and gene splicing evolution across species and search of tissue-specific gene expression and splicing patterns. We also used the gene expression information of genes encoding metabolic enzymes in this dataset to support a larger comparative study of metabolome evolution in the same set of tissues and species.
    Organism:
    Macaca mulatta; Pan troglodytes; Homo sapiens; Mus musculus
    Type:
    Expression profiling by high throughput sequencing
    4 related Platforms
    120 Samples
    Download data:
    GEO (TSV), SRA SRP028336
    Series
    Accession:
    GSE49379
    ID:
    200049379

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