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    Results: 9

    1.
    Full record GDS3145

    Cerebral malaria model: time course

    Analysis of brains of C57/B6 and Balb/C animals for up to 6 days following infection with Plasmodium berghei ANKA. Experimental infection of animals with P. berghei ANKA is a model for cerebral malaria (CM). C57/B6 animals are susceptible to cerebral malaria (CM), Balb/C animals are resistant.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, count, 2 infection, 2 strain, 4 time sets
    Platform:
    GPL8321
    Series:
    GSE7814
    64 Samples
    Download data:
    GEO (CEL)
    2.

    Transcriptional Profiling of Cerebral Malaria

    (Submitter supplied) Cerebral malaria (CM) is a leading cause of death in the world. Better understanding of the pathogenesis of this disease is critical for the development of novel therapies. In this work, we investigated temporal gene expression profiles in the brains of CM-susceptible and CM-resistant mice during infection with P. Berghia ANKA (PbA). In this model of CM, susceptible mice develop neurological signs by day 6 post infection while resistant mice do not develop neurological manifestations during malarial infection. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Dataset:
    GDS3145
    Platform:
    GPL8321
    64 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE7814
    ID:
    200007814
    3.

    Simultaneous Host and Parasite Expression Profiling Identifies Transcriptional Programs Associated with Cerebral Malaria

    (Submitter supplied) The development and outcome of cerebral malaria (CM) reflects a complex interplay between parasite-expressed virulence factors and host response to infection. To simultaneously analyze transcriptional programs in both parasite and host over the course of infection, we created microarrays to concurrently detect transcripts in the genomes of both Plasmodium berghei and mouse. Analysis of RNA from brain, lung, liver, and spleen of mice infected with P. more...
    Organism:
    Mus musculus; Plasmodium berghei
    Type:
    Expression profiling by array
    Platform:
    GPL4220
    13 Samples
    Download data:
    GEO (GPR)
    Series
    Accession:
    GSE5672
    ID:
    200005672
    4.

    Acute Lung Injury In Experimental Malaria

    (Submitter supplied) Although respiratory distress is a common complication of severe malaria, little is known about the underlying molecular basis of lung dysfunction. Animal models have provided powerful insights into the pathogenesis of severe malaria syndromes such as cerebral malaria; however, no model of malaria-induced lung injury has been definitively established. This work used bronchoalveolar lavage (BAL), histopathology and gene expression analysis to examine the development of acute lung injury (ALI) in mice infected with Plasmodium berghei ANKA (PbA). more...
    Organism:
    Plasmodium berghei; Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL4220
    4 Samples
    Download data:
    GEO (GPR)
    Series
    Accession:
    GSE9497
    ID:
    200009497
    5.

    Predominance of interferon-related responses in the brain during murine malaria as identified by microarray analysis.

    (Submitter supplied) Cerebral malaria (CM) can be a fatal manifestation of Plasmodium falciparum infection. We examined global gene expression patterns by microarray during fatal murine CM (FMCM) and non-cerebral malaria (NCM). There was differential expression of a number of genes, including some not yet characterized in the pathogenesis of FMCM. Some gene induction was observed during Plasmodium infection regardless of the development of CM and there was a predominance of genes linked to IFN responses, even in NCM. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platforms:
    GPL1261 GPL1832
    19 Samples
    Download data:
    GEO (CEL, CHP, GPR)
    Series
    Accession:
    GSE9808
    ID:
    200009808
    6.

    Common Irf-regulated genomic responses drive pathological inflammation during experimental cerebral malaria as well as protective response against M. tuberculosis

    (Submitter supplied) Analysis of transcriptional response to Plasmodium berghei ANKA infection in cerebral malaria susceptible C57BL/6 mouse brains as well as cerebral malaria resistant BXH2 mice which carry a severe hypomorphic Irf8-R294C allele. Interferon Regulatory Factor 8 (IRF8) is required for development, maturation and expression of anti-microbial defenses of myeloid cells. BXH2 mice harbor a loss-of-function allele at Irf8 (Irf8-R294C) that causes susceptibility to infection with intracellular pathogens, including Mycobacterium tuberculosis. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL6887
    4 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE65036
    ID:
    200065036
    7.

    Distinct pathways of pathogenesis in mice with experimental cerebral malaria following P. berghei ANKA infection.

    (Submitter supplied) Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection, predominantly experienced by children and non-immune adults, which results in great mortality and long-term sequelae. Recent reports based on histology of post-mortem brain tissue suggest that CM may be the common end point for a range of syndromes. Here, we have analysed the gene expression profiles in brain tissue taken from experimental CM (ECM)-susceptible, Plasmodium berghei ANKA (PbA)-infected C57BL/6 (B6) and CBA/CaH (CBA) mice with ECM. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Dataset:
    GDS3118
    Platform:
    GPL1261
    4 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE6019
    ID:
    200006019
    8.
    Full record GDS3118

    Cerebral malaria model

    Analysis of C57BL/6 and CBA/CaH animals infected with Plasmodium berghei ANKA to induce experimental cerebral malaria (ECM). CM is a complication of P. falciparum infection. ECM in B6 and CBA displays many features of human CM. Results provide insight into the development of treatments for human CM.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, count, 2 disease state, 2 strain sets
    Platform:
    GPL1261
    Series:
    GSE6019
    4 Samples
    Download data:
    GEO (CEL)
    9.

    Effect of Plasmodium falciparum infected erythrocytes on primary human brain microvascular endothelial cell

    (Submitter supplied) Cerebral malaria is a severe multifactorial condition associated with the interaction of high numbers of infected erythrocytes to human brain endothelium without invasion into the brain. The result is coma and seizures with death in more than 20% of cases. Because the brain endothelium is at the interface of these processes, we investigated the global gene responses of human brain endothelium after the interaction with Plasmodium falciparum–infected erythrocytes with either high- or low-binding phenotypes. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL571
    8 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE9861
    ID:
    200009861

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