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Items: 20

1.

Long noncoding RNA expression in several hematopoietic progenitor and differentiated cell populations

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Third-party reanalysis; Expression profiling by array; Non-coding RNA profiling by array
Platform:
GPL17864
19 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE52555
ID:
200052555
2.

Global Transcriptome Analyses of Mammalian Terminal Erythroid Differentiation

(Submitter supplied) Purpose:The purpose of this study is to create unbiased, stage-specific transcriptomes by RNA-seq analyses of pure populations of both murine and human erythroblasts at distinct developmental stages. Methods: Recently developed FACS-based methods (Chen et al, PNAS, Liu et al, Blood, Hu et al Blood) were employed to purify morphologically and functionally discrete populations of cells, each representing specific stages of terminal erythroid differentiation. more...
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL13112 GPL11154
27 Samples
Download data:
GEO (TXT), SRA SRP035312
Series
Accession:
GSE53983
ID:
200053983
3.

Long noncoding RNA expression in several hematopoietic progenitor and differentiated cell populations using a custom Agilent microarray

(Submitter supplied) Mammals express thousands of long noncoding (lnc) RNAs, a few of which are shown to function in tissue development. However, the entire repertoire of lncRNAs and the extent to which they regulate biological processes in different tissues and species are not defined. Indeed, most lncRNAs are not conserved between species, raising questions about function. We used RNA-Seq to identify lncRNAs in primary murine fetal liver erythroblasts expressing the lineage marker TER119, megakaryocytes (CD41+) cultured from embryonic day (E) 14.5 murine fetal liver and megakaryocyte erythroid progenitors (MEPs) isolated from mouse bone marrow. more...
Organism:
Mus musculus
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platform:
GPL17864
19 Samples
Download data:
GEO (TXT)
4.

Expression of novel long noncoding RNAs during erythro-megakaryopoiesis and GATA1-induced erythroid differentiation using RNA-seq

(Submitter supplied) Mammals express thousands of long noncoding (lnc) RNAs, a few of which are shown to function in tissue development. However, the entire repertoire of lncRNAs and the extent to which they regulate biological processes in different tissues and species are not defined. Indeed, most lncRNAs are not conserved between species, raising questions about function. We used RNA-Seq to identify lncRNAs in primary murine fetal liver erythroblasts expressing the lineage marker TER119, megakaryocytes (CD41+) cultured from embryonic day (E) 14.5 murine fetal liver and megakaryocyte erythroid progenitors (MEPs) isolated from mouse bone marrow. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Third-party reanalysis
Download data:
GEO (GTF, TXT)
Series
Accession:
GSE51667
ID:
200051667
5.

Global discovery of erythroid long non-coding RNAs reveals novel regulators of red cell maturation

(Submitter supplied) Erythropoiesis is regulated at multiple levels to ensure the proper generation of mature red cells under multiple physiological conditions. To probe the contribution of long non-coding RNAs (lncRNAs) to this process, we examined >1 billion RNA-Seq reads of polyadenylated and nonpolyadenylated RNA from differentiating mouse fetal liver red blood cells, and identified 655 lncRNA genes including not only intergenic, antisense and intronic but also pseudogene and enhancer loci. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
4 Samples
Download data:
GEO (BW), SRA SRP032700
Series
Accession:
GSE52126
ID:
200052126
6.

Chromatin signatures at transcriptional start sites separate two equally populated yet distinct classes of intergenic long noncoding RNAs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other
Platforms:
GPL13112 GPL11002
6 Samples
Download data:
GEO (WIG)
Series
Accession:
GSE49460
ID:
200049460
7.

Transcription Start Site analysis of Mouse Ter119+ erythroid cells

(Submitter supplied) Transcription Start Site analysis in Mouse Ter119+ erythroid cells
Organism:
Mus musculus
Type:
Other
Platform:
GPL13112
1 Sample
Download data:
GEO (WIG), SRA SRP028399
Series
Accession:
GSE49459
ID:
200049459
8.

Genome-wide maps of chromatin accessibility in C57bl\6 mouse erythroid cells.

(Submitter supplied) Genome-wide identification of active regions in the mouse erythroid genome using DNase-seq.
Organism:
Mus musculus
Type:
Other
Platform:
GPL13112
1 Sample
Download data:
GEO (WIG), SRA SRP028398
Series
Accession:
GSE49458
ID:
200049458
9.

Transcriptome analysis of Mouse Ter119+ erythroid cells [PolyA+]

(Submitter supplied) Analysis of gene expression in Mouse Ter119+ erythroid cells
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
1 Sample
Download data:
GEO (WIG), SRA SRP028397
Series
Accession:
GSE49457
ID:
200049457
10.

Transcriptome analysis of Mouse Ter119+ erythroid cells [PolyA-]

(Submitter supplied) Analysis of Non-Polyadenylated gene expression in Mouse Ter119+ erythroid cells
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11002
1 Sample
Download data:
GEO (WIG), SRA SRP028396
Series
Accession:
GSE49456
ID:
200049456
11.

Genome-wide maps of chromatin modifications in C57bl\6 mouse erythroid cells.

(Submitter supplied) Regions of chromatin modified by H3K4me1 and H3K4me3 were identified in mouse erythroid cells using ChIP-seq.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
2 Samples
Download data:
GEO (WIG), SRA SRP028395
Series
Accession:
GSE49455
ID:
200049455
12.

Expression profiling of human CD34+ cells derived from mobilized peripheral blood samples after overexpression of MEIS1B or MEIS1D

(Submitter supplied) MEIS1 is a transcription factor expressed in hematopoietic stem and progenitor cells (HSPC) and in mature megakaryocytes. In contrast to its role in leukemogenesis, the role of MEIS1 in normal hematopoiesis is largely unknown. We show that MEIS1 can direct human hematopoietic progenitors towards a megakaryocyte-erythroid progenitor (MEP) fate. Ectopoic expression of MEIS1 in CD34+ cells resulted in increased erythroid differentiation at the expense of granulocyte and monocyte (GM) differentiation. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
9 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE53263
ID:
200053263
13.

RNA-seq of poly(A)-/ribo- or poly(A)+ RNAs from mouse and rhesus ES cells

(Submitter supplied) We have used RNA-seq to examine circular RNAs from RNase R treated poly(A)-/ribo- RNAs in human embryonic stem cells
Organism:
Macaca mulatta; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL13112 GPL14954
6 Samples
Download data:
GEO (BW), SRA SRP035263
Series
Accession:
GSE53942
ID:
200053942
14.

ESlncRNA (AK148461) over-expression on gene expression

(Submitter supplied) We over-expressed ESlncRNA (AK148461) in fetal liver erythroid progenitor cells (Lin-cells), followed by microarray analysis to examine the global changes of gene expression level. We showed that ESlncRNA has an anti-apoptotic activity during mouse erythropoiesis.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
2 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE30279
ID:
200030279
15.

Expression data from Fog1+/+ and Fog1 ki/ki mouse megakaryocyte-erythroid progenitors (MEP).

(Submitter supplied) The transcription co-factor FOG1 interacts with the chromatin remodeling complex NuRD to mediate gene activation and gene repression during hematopoiesis. We have generated mice with a targeted mutation in the endogenous Fog1 locus that results in an N-ternimal mutation in FOG1 that disrupts the interaction with NuRD. We used gene expression microarrays to explore the global transcriptional programs regulated by FOG1 and NuRD in megakaryocyte-erythroid progenitors (MEP) to aid in understanding its role during hematopoiesis.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data:
GEO (CEL)
Series
Accession:
GSE19497
ID:
200019497
16.

Developmentally regulated lncRNAs expression in male germline

(Submitter supplied) To decipher the roles of non-coding RNAs during male germline development, we use the lncRNAs microarray to profile the genome-wide lncRNAs expression pattern in the male germline
Organism:
Mus musculus
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platform:
GPL15691
18 Samples
Download data:
GEO (XLS)
Series
Accession:
GSE46896
ID:
200046896
17.

Gene expression changes induced in K562 cells by the homeobox gene DLX4 and by treatment with Activin A and phorbol 12-myristate 13-acetate

(Submitter supplied) Homeobox genes encode transcription factors that control patterning of virtually all organ systems including the hematopoietic system. However, the role of homeobox genes in controlling development of the erythroid and megakaryocytic lineages is poorly understood. In this study, we investigated the role of the homeobox gene DLX4 in erythroid and megakaryocytic differentiation using the bipotent cell line K562 as a model. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
24 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE63888
ID:
200063888
18.

Characterization of the coding and noncoding transcriptome in undifferentiated and differentiating mouse embryonic stem cells

(Submitter supplied) RNA (poly(A)+ fraction) has ben isolated from undifferentiated mouse embryonic stem cells and from embryonic stem cells induced to differentiate using the hanging drop model, 6 days following iinduction of differentiation. Profiling of the transcritome at these two stages of differentiation using deep RNA sequencing allows identifying modulated coding and noncoding transcripts upon induction of differentiation.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL9250
6 Samples
Download data:
GEO (GTF, TXT), SRA SRP045263
Series
Accession:
GSE60097
ID:
200060097
19.

Profiling of long noncoding RNAs and mRNAs in neonatal and adult mouse testis

(Submitter supplied) Todate, the investigation into the molecular mechanisms of testis development and spermatogenesis has largely focused on the role of protein-coding genes and small noncoding RNA including microRNAs and piRNAs. In recent years, long noncoding RNAs (lncRNAs) have been shown to play critical regulatory roles in mammalian development. To understand the role of lncRNAs in development of the mammalian testis and spermatogenesis, we firstly utilized commercial microarray to systematically investigate lncRNAs expression profiles of neonatal (6-day-old) and adult (8-week-old) mouse testis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL15692
6 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE43442
ID:
200043442
20.

Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development

(Submitter supplied) To identify potential biological functions for three lncRNAs (NANCI, LL12, and LL34) we used shRNAs to knockdown expression of lncRNAs in MLE12 cells, a cell resembling type two lung epithelial cells. This data set contains the microarrays looking at gene expression.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
12 Samples
Download data:
GEO (CEL)
Series
Accession:
GSE52389
ID:
200052389
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