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    Results: 15

    1.

    Lympho-myeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells

    (Submitter supplied) An immune-restricted lymphomyeloid-primed progenitor with the capacity to contribute to both myeloid and lymphoid lineages in the developing embryo emerges prior to definitive HSCs.
    Organism:
    Mus musculus
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL13112
    26 Samples
    Download data:
    GEO (TXT), SRA SRP052999
    Series
    Accession:
    GSE50896
    ID:
    200050896
    2.

    Reduced lymphoid lineage priming promotes human hematopoietic stem cell expansion

    (Submitter supplied) Hematopoietic stem cells (HSCs) must balance self-renewal and lineage differentiation to regenerate the hematopoietic system throughout life. HSCs exhibit lineage-associated gene expression that keeps them responsive to demands of mature blood production. However, it is not known whether this process, termed lineage priming, directly influences HSC self-renewal. We investigated the link between stemness and lineage priming by attenuating the early lymphoid transcription factor E47 through ID2 over-expression (OE). more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL14951
    6 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE45486
    ID:
    200045486
    3.

    IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid progenitors

    (Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platforms:
    GPL1261 GPL15097
    13 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE34917
    ID:
    200034917
    4.

    IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid progenitors (Illumina).

    (Submitter supplied) While most blood lineages are assumed to mature through a single cellular and developmental route downstream of hematopoietic stem cells (HSCs), dendritic cells (DCs) can be derived from both myeloid and lymphoid progenitors in vivo. To determine how distinct progenitors can generate similar downstream lineages, we examined the transcriptional changes that accompany loss of in vivo myeloid potential as common myeloid progenitors (CMPs) differentiate into common dendritic cell progenitors (CDPs), and as lymphoid-primed multipotent progenitors (LMPPs) differentiate into all lymphoid progenitors (ALPs). more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL15097
    8 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE34915
    ID:
    200034915
    5.

    IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid progenitors (Affymetrix).

    (Submitter supplied) While most blood lineages are assumed to mature through a single cellular and developmental route downstream of hematopoietic stem cells (HSCs), dendritic cells (DCs) can be derived from both myeloid and lymphoid progenitors in vivo. To determine how distinct progenitors can generate similar downstream lineages, we examined the transcriptional changes that accompany loss of in vivo myeloid potential as common myeloid progenitors (CMPs) differentiate into common dendritic cell progenitors (CDPs), and as lymphoid-primed multipotent progenitors (LMPPs) differentiate into all lymphoid progenitors (ALPs). more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL1261
    5 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE34892
    ID:
    200034892
    6.

    DNA methylation data from mouse hematopoietic progenitors

    (Submitter supplied) Genome-wide DNA methylation was studied to determine the methylome map of lymphoid and myeoloid commitment from hematopoietic progenitors We used custom Nimblegen microarrays to determine the genome-wide DNA methylation in FACs purified mouse hematopoietic progeniors
    Organism:
    Mus musculus
    Type:
    Methylation profiling by genome tiling array
    Platforms:
    GPL10680 GPL10683
    35 Samples
    Download data:
    GEO (XYS)
    Series
    Accession:
    GSE23110
    ID:
    200023110
    7.

    A comprehensive methylome map of lineage commitment from hematopoietic progenitors

    (Submitter supplied) Epigenetic modifications must underlie lineage-specific differentiation since terminally differentiated cells express tissue-specific genes, but their DNA sequence is unchanged. Hematopoiesis provides a well-defined model of progressive differentiation in which to study the role of epigenetic modifications in cell fate decisions. Multi-potent progenitors (MPPs) can differentiate into all blood cell lineages, while downstream progenitors commit to either myeloerythroid or lymphoid lineages. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL1261
    26 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE20244
    ID:
    200020244
    8.

    Generation of hematopoietic progenitor cell lines with myeloid and lymphoid potential using a conditional form of Hoxb8

    (Submitter supplied) Investigation of immune-cell differentiation and function is limited by shortcomings of suitable and scalable experimental systems. Here we show that retroviral delivery of an estrogen-regulated form of Hoxb8 into mouse bone marrow cells can be used along with Flt3 ligand to conditionally immortalize early hematopoietic progenitor cells (Hoxb8-FL cells). Hoxb8-FL cells have lost self-renewal capacity and potential to differentiate into megakaryocytes and erythrocytes but retain the potential to differentiate into myeloid and lymphoid cells. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL1261
    4 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE45759
    ID:
    200045759
    9.

    Analysis of differential gene expression in Cebpa-positive and Cebpa-negative hematopoietic stem cells using a Cebpa-Cre EYFP reporter mouse model

    (Submitter supplied) C/EBPalpha is a transcription factor critically involved in myeloid development and indispensable for formation of granulocytes. To track the cellular fate of stem and progenitor (LSK) cells, which express C/EBPalpha, we developed a mouse model expressing Cre recombinase from the Cebpa promoter and an inducible EYFP allele. We show that Cebpa/EYFP+ cells represent a significant subset of LSK cells, which predominantly give rise to myeloid cells in steady state hematopoiesis. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL1261
    11 Samples
    Download data:
    GEO (CEL, TXT)
    Series
    Accession:
    GSE23800
    ID:
    200023800
    10.

    E47 KO versus WT HSCs

    (Submitter supplied) Genome-wide gene expression pattern of E47 KO versus WT HSCs from primary and secondary recipient mice were analysis using Agilent one-color micro-array analysis.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL4134
    8 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE26788
    ID:
    200026788
    11.

    Deletion of the NF-κB subunit p65/RelA in the hematopoietic compartment leads to defects in hematopoietic stem cell function.

    (Submitter supplied) Deletion of the NF-κB subunit p65/RelA in the hematopoietic compartment results in gene expression changes in lineage-Flk2-c-kit+Sca-1+ cells from mouse bone marrow.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL6246
    6 Samples
    Download data:
    GEO (CEL, CHP)
    Series
    Accession:
    GSE45755
    ID:
    200045755
    12.

    Gene expression profiling and ChIP-Seq study of HoxB4-mediated HSC development from ES cells

    (Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
    Organism:
    Mus musculus
    Type:
    Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array
    Platforms:
    GPL6246 GPL9250
    18 Samples
    Download data:
    GEO (CEL, WIG)
    Series
    Accession:
    GSE34014
    ID:
    200034014
    13.

    Time-course HoxB4 ChIP-Seq during HSC development from ES cells

    (Submitter supplied) Efficient in vitro generation of hematopoietic stem cells (HSCs) from embryonic stem cells (ESCs) holds great promise for cell-based therapies of hematological diseases. To date, HoxB4 remains to be the most effective transcription factor (TF) whose over-expression in ESCs confers long-term repopulating ability to ESC-derived HSCs. Despite its importance, the components and dynamics of the HoxB4 transcriptional regulatory network is poorly understood, hindering efforts to develop a more efficient protocol for in vitro derivation of HSCs. more...
    Organism:
    Mus musculus
    Type:
    Genome binding/occupancy profiling by high throughput sequencing
    Platform:
    GPL9250
    6 Samples
    Download data:
    GEO (WIG), SRA SRP009471
    Series
    Accession:
    GSE34013
    ID:
    200034013
    14.

    Time-course transcriptome measure of HoxB4-mediated HSC development from ES cells

    (Submitter supplied) Efficient in vitro generation of hematopoietic stem cells (HSCs) from embryonic stem cells (ESCs) holds great promise for cell-based therapies of hematological diseases. To date, HoxB4 remains to be the most effective transcription factor (TF) whose over-expression in ESCs confers long-term repopulating ability to ESC-derived HSCs. Despite its importance, the components and dynamics of the HoxB4 transcriptional regulatory network is poorly understood, hindering efforts to develop a more efficient protocol for in vitro derivation of HSCs. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL6246
    12 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE33953
    ID:
    200033953
    15.

    Gene expression of 4, 5, and 6 days differentiated Flk1+ WT ES cells, and of 6 days differentiated Flk1+ Runx1-/- and Tal-1-/- ES cells

    (Submitter supplied) In order to identify genes that are activated in differentiating WT ESCs, but are missing in Tal-1-/- and Runx1-/- ESCs, and which might be involved in the generation of definitive hematopoietic progenitors and their specification thereafter, we performed microarray analyses on purified Flk-1+ cells, differentiated from these ESCs for 4, 5, and 6 days “in vitro”.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL1261
    15 Samples
    Download data:
    GEO (CEL, CHP)
    Series
    Accession:
    GSE46970
    ID:
    200046970

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