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    Results: 20

    1.

    Buccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies [Bisulfite-Seq]

    (Submitter supplied) There is increasing evidence that interindividual epigenetic variation is an etiological factor in common human diseases. Such epigenetic variation could be genetic or non-genetic in origin, and epigenome-wide association studies (EWASs) are underway for a wide variety of diseases/phenotypes. However, performing an EWAS is associated with a range of issues not typically encountered in genome-wide association studies (GWASs), such as the tissue to be analyzed. more...
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by high throughput sequencing
    Platform:
    GPL11154
    28 Samples
    Download data:
    GEO (TXT), SRA SRP022041
    Series
    Accession:
    GSE46572
    ID:
    200046572
    2.

    Buccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies [Illumina tiling]

    (Submitter supplied) There is increasing evidence that interindividual epigenetic variation is an etiological factor in common human diseases. Such epigenetic variation could be genetic or non-genetic in origin, and epigenome-wide association studies (EWASs) are underway for a wide variety of diseases/phenotypes. However, performing an EWAS is associated with a range of issues not typically encountered in genome-wide association studies (GWASs), such as the tissue to be analyzed. more...
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by genome tiling array
    Platform:
    GPL13534
    22 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE46573
    ID:
    200046573
    3.

    Buccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies

    (Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by genome tiling array; Methylation profiling by high throughput sequencing
    Platform:
    GPL13534
    22 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE45529
    ID:
    200045529
    4.

    Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population

    (Submitter supplied) The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in whole blood samples from 172 normal female twins. See Bell, Tsai et al. Plos Genet. 2012;8(4):e1002629.
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by array
    Platform:
    GPL8490
    172 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE58045
    ID:
    200058045
    5.

    Methylation profiling in Ulcerative colitis

    (Submitter supplied) The series was designed to identify the different methylated single CpGs involved in the pathophysiology of ulcerative colitis.
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by array; Methylation profiling by genome tiling array
    Platforms:
    GPL13269 GPL8490
    40 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE27899
    ID:
    200027899
    6.

    Genome wide expression data from discordant twins (ulcerative colitis, primary mucosal tissue)

    (Submitter supplied) Background and aims. The etiopathology of inflammatory bowel diseases is still poorly understood. To date, only few little data are available on the microbiota composition in ulcerative colitis (UC), representing a major subform of inflammatory bowel diseases. Currently, one of the main challenges is to unravel the interactions between genetics and environmental factors in the onset or during the progression and maintenance of the disease. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Dataset:
    GDS4519
    Platform:
    GPL570
    20 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE22619
    ID:
    200022619
    7.
    Full record GDS4519

    Monozygotic twin pairs discordant for ulcerative colitis: intestinal biopsies

    Analysis of colon mucosal tissue from 10 monozygotic (MZ) twins discordant for ulcerative colitis (UC). Twins (paired samples) were analyzed to obtain mucosal response data independent of genetic variation. Results provide insight into molecular mechanisms underlying UC.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 2 disease state, 10 individual sets
    Platform:
    GPL570
    Series:
    GSE22619
    20 Samples
    Download data:
    GEO (CEL)
    8.

    Cigarette Smoking Reduces DNA Methylation Levels at Multiple Genomic Loci but the Effect is Partially Reversible upon Cessation

    (Submitter supplied) DNA methylation is an epigenetic event whose pattern is altered frequently in a wide variety of human diseases. Smoking affects DNA methylation possibly leading to abnormal expression of a broad spectrum of genes which in turn may result to the various side effects and diseases associated with smoking. The long term effects of smoking have been widely studied but the mechanism(s) by which those effects may be reversible by smoking cessation are not clearly understood. more...
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by array
    Platform:
    GPL13534
    464 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE50660
    ID:
    200050660
    9.

    ChIP-chip from the follicular lymphoma cell line RL with H3K4me3, H3K37me3 and Suz12

    (Submitter supplied) We conducted genome-wide bisulfite sequencing analysis of the follicular lymphoma cell line RL and found that a large amount of methylated genes are polycomb target genes in ES cells. We therefore conducted a ChIP-chip experiment to determine the methylated genes that are bound by the polycomb protein Suz12. Although 28% of MRIs are PRC2 target genes in ES cells, our ChIP-on-Chip analysis showed that only 13% of MRIs are associated with H3K27Me3 marks and only 5% of the MRIs are bound by Suz12 in RL cells in vivo.
    Organism:
    Homo sapiens
    Type:
    Genome binding/occupancy profiling by genome tiling array
    Platform:
    GPL7408
    3 Samples
    Download data:
    GEO (PAIR)
    Series
    Accession:
    GSE20019
    ID:
    200020019
    10.

    DNA methylation in peripheral blood from individuals with Crohns' disease or ulcerative colitis and normal controls

    (Submitter supplied) Genome wide DNA methylation profiling of Crohn's disease, ulcerative colitis, and normal peripheral blood samples. The Illumina Infinium HumanMethylation450 BeadChip v1.1 was used to obtain DNA methylation profiles across 482,421 CpGs in peripheral blood samples. Samples came from 17 Crohn's disease affected, 11 ulcerative colitis affected, and 20 normal individuals. Within these samples were three twin sets discordant for Crohn's disease and three twin sets discordant for ulcerative colitis.
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by genome tiling array
    Platform:
    GPL13534
    48 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE32148
    ID:
    200032148
    11.

    Genome-Wide Analysis of Acute Myeloid Leukemia Reveals Leukemia-Specific Methylome and Subtype-Specific Hypomethylation of Repeats

    (Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by high throughput sequencing; Expression profiling by array
    Platforms:
    GPL9115 GPL9851
    22 Samples
    Download data:
    GEO (GFF, WIG)
    Series
    Accession:
    GSE37022
    ID:
    200037022
    12.

    Gene expression profiling of Acute Myeloid Leukemia (AML) samples

    (Submitter supplied) The aim was to analyze the expression of genes in cytogenetically distinct cases of AML.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL9851
    6 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE34722
    ID:
    200034722
    13.

    Genome-wide study of DNA methylation in AML by MeDIP-seq

    (Submitter supplied) Methylated DNA immunoprecipitation followed by high-throughput sequencing (MeDIP-seq) has the potential to identify changes in DNA methylation important in cancer development. In order to understand the role of epigenetic modulation in the development of acute myeloid leukemia (AML) we have applied MeDIP-seq to the DNA of 12 AML patients and 4 normal bone marrows. This analysis revealed leukemia-associated differentially methylated regions that included gene promoters, gene bodies, CpG islands and CpG island shores. more...
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by high throughput sequencing
    Platform:
    GPL9115
    16 Samples
    Download data:
    GEO (GFF, TXT, WIG), SRA SRP007961
    Series
    Accession:
    GSE28314
    ID:
    200028314
    14.

    Differential DNA methylation in Rheumatoid arthritis

    (Submitter supplied) Genome-wide DNA methylation level was studied to determine whether Rheumatoid arthritis patients (cases) has methylation differences comparing to normal controls in peripheral blood leukocytes (PBLs). We used Illumina HumanMethylation450 BeadChip array to determine the genome-wide DNA methylation difference in PBLs from Rheumatoid arthritis patients (cases) and normal controls
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by array
    Platform:
    GPL13534
    689 Samples
    Download data:
    GEO (IDAT, TXT)
    Series
    Accession:
    GSE42861
    ID:
    200042861
    15.

    Comparison of DNA methylation in human tissues

    (Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing
    Platforms:
    GPL9115 GPL11154
    9 Samples
    Download data:
    GEO (BED, TAR)
    Series
    Accession:
    GSE39777
    ID:
    200039777
    16.

    Examination of gene expression in human placenta using RNA-seq

    (Submitter supplied) As genome-scale DNA methylation sequencing technologies have improved it has become apparent that tissue-specific methylation can occur not only at promoters, enhancers, and CpG islands but also over larger genomic regions. In most human tissues, the vast majority of the genome is highly methylated (>70%). However, genomic sequencing of bisulfite-treated DNA (MethylC-seq) has revealed large partially methylated domains (PMDs) in some human cell lines. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL11154
    2 Samples
    Download data:
    GEO (FPKM_TRACKING), SRA SRP014635
    Series
    Accession:
    GSE39776
    ID:
    200039776
    17.

    Examination of four human tissue samples by MethylC-seq

    (Submitter supplied) As genome-scale DNA methylation sequencing technologies have improved it has become apparent that tissue-specific methylation can occur not only at promoters, enhancers, and CpG islands but also over larger genomic regions. In most human tissues, the vast majority of the genome is highly methylated (>70%). However, genomic sequencing of bisulfite-treated DNA (MethylC-seq) has revealed large partially methylated domains (PMDs) in some human cell lines. more...
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by high throughput sequencing
    Platforms:
    GPL11154 GPL9115
    7 Samples
    Download data:
    GEO (BED, TAR), SRA SRP014634
    Series
    Accession:
    GSE39775
    ID:
    200039775
    18.

    Methylation data from CD4+ cells at birth and 12 months from a cohort of children who were diagnosed with IgE food allergy to either egg milk or peanut at 12 months (n=12) and healthy controls (n=12).

    (Submitter supplied) DNA methylation data derived from total CD4+ T-cells from a cohort of paediatric food allergy. There are 12 food allergic samples (6 activated and matched control), 12 non-allergic samples (6 activated and matched control) collected at birth and resample at 12-months, total 48 samples. Mononuclear cells were either activated with anti-CD3 (0.5 ug/mL) + IL2(20U) or rested in media alone for 24 hours. more...
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by array
    Platform:
    GPL13534
    48 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE34639
    ID:
    200034639
    19.

    DNA Methylome in Human Peripheral Blood Monocytes

    (Submitter supplied) Purpose: We characterized genome-wide DNA methylation profiles (methylome) in purified peripheral blood monocytes (PBMs) from 18 healthy postmenopausal Caucasian females aged 50-56 years. Methods: DNA methylome of Human Peripheral Blood Monocytes were generated by methylated DNA immunoprecipitation combined with high-throughput sequencing (MeDIP-seq), using Illumina GAIIx. The sequence reads that passed quality filters were analyzed using MEDIPS package. more...
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by high throughput sequencing
    Platform:
    GPL10999
    18 Samples
    Download data:
    GEO (TXT), SRA SRP014554
    Series
    Accession:
    GSE39604
    ID:
    200039604
    20.

    Reprogramming of the Human Intestinal Epigenome by Surgical Tissue Transposition

    (Submitter supplied) Genome-wide DNA methylation profiling of human ileal neobladder samples.
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by array
    Platform:
    GPL13534
    45 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE50475
    ID:
    200050475

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