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    Results: 5

    1.

    Inferring Epitopes of a Polymorphic Antigen Amidst Broadly Cross-Reactive Antibodies Using Protein Microarrays: a Study of OspC Proteins of Borrelia burgdorferi

    (Submitter supplied) Epitope mapping studies aim to identify the binding sites of antibody-antigen interactions to enhance the development of vaccines, diagnostics and immunotherapeutic compounds. However, mapping is a laborious process employing time- and resource-consuming ‘wet bench’ techniques or epitope prediction software that are still in their infancy. For polymorphic antigens, another challenge is characterizing cross-reactivity between epitopes, teasing out distinctions between broadly cross-reactive responses, limited cross-reactions among variants and the truly type-specific responses. more...
    Organism:
    Peromyscus leucopus; Homo sapiens; Borrelia burgdorferi
    Type:
    Protein profiling by protein array
    Platform:
    GPL17008
    110 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE45996
    ID:
    200045996
    2.

    Diversity of antibody responses to Borrelia burgdorferi in experimentally-infected beagle dogs

    (Submitter supplied) Lyme borreliosis (LB) is a common infection of domestic dogs in areas where there is enzootic transmission of the agent Borrelia burgdorferi. Immunodiagnostic assays for canine antibodies to B. burgdorferi are usually based on whole-cell preparations as substrate and, consequently, interpretation of results is confounded by antibody cross-reactivity between borrelial antigens and those of other bacterial species. more...
    Organism:
    Canis lupus familiaris; Borrelia burgdorferi
    Type:
    Protein profiling by protein array
    Platform:
    GPL17606
    36 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE50074
    ID:
    200050074
    3.

    Analysis of the human endothelial cell response to Borrelia burgdorferi wild-type and deleted in the gene encoding the integrin ligand P66

    (Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platforms:
    GPL13290 GPL5936
    38 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE27996
    ID:
    200027996
    4.

    Analysis of the human endothelial cell response to Borrelia burgdorferi wild-type and deleted in the gene encoding the integrin ligand P66 [experiment B]

    (Submitter supplied) The overall goal of these experiments was to determine how human cells respond to ontegrin binding by Borrelia burgdorferi. Lyme disease is the most common vector-borne infection in the Northern hemisphere, yet little is understood about the pathogenic mechanisms of the causative agent, Borrelia burgdorferi. Cells in culture were infected with the bacteria that do and do not express the beta3 integrin ligand P66, which are otherwise isogenic. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL13290
    16 Samples
    Download data:
    GEO (TXT, XLS)
    Series
    Accession:
    GSE27995
    ID:
    200027995
    5.

    Analysis of the human endothelial cell response to Borrelia burgdorferi wild-type and deleted in the gene encoding the integrin ligand P66 [experiment A]

    (Submitter supplied) The overall goal of these experiments was to determine how human cells respond to ontegrin binding by Borrelia burgdorferi. Lyme disease is the most common vector-borne infection in the Northern hemisphere, yet little is understood about the pathogenic mechanisms of the causative agent, Borrelia burgdorferi. Cells in culture were infected with the bacteria that do and do not express the beta3 integrin ligand P66, which are otherwise isogenic. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL5936
    22 Samples
    Download data:
    GEO (TXT, XLS)
    Series
    Accession:
    GSE27252
    ID:
    200027252

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