Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

    Results: 20

    1.

    Genome-wide DNA methylation profiles of human hepatocellular carcinoma

    (Submitter supplied) Introduction: Hepatocellular carcinoma (HCC) is one of the most aggressive solid tumors and oncogenic pathways (e.g Akt, IGF signaling) are often activated in high proliferating HCC. Among several genetic alterations, epigenetic changes seem to be involved in the development and progression of HCC. DNA hypermethylation of promoter regions is almost always associated with transcriptional silencing and can lead to inactivation of tumor suppressor genes (TSG) in cancer cells. more...
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by array
    Platform:
    GPL8490
    102 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE44970
    ID:
    200044970
    2.

    Epigenome analysis of HCC samples with paired adjacent tissue

    (Submitter supplied) Genome wide DNA methylation profiling of paired adjacent and hepatocellular samples and 8 non-diseased liver samples. The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs. Samples included 12 paired adjacent and 12 hepatocellular samples.
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by array
    Platform:
    GPL8490
    32 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE44909
    ID:
    200044909
    3.

    Integrative array-based approach identifies MZB1 as a frequently methylated putative tumor-suppressor in hepatocellular carcinoma

    (Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array; Methylation profiling by genome tiling array
    Platforms:
    GPL4126 GPL4133
    20 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE35313
    ID:
    200035313
    4.

    Integrative array-based approach identifies MZB1 as a frequently methylated putative tumor-suppressor in hepatocellular carcinoma (MeDIP)

    (Submitter supplied) The analysis of DNA methylation profiles was performed by methylated DNA immunoprecipitation (MeDIP) using anti-5-methylcytidine antibody (Eurogentec, Seraing, Belgium) followed by the Human 244K Agilent CpG island microarray (Agilent, Santa Clara, CA)
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by genome tiling array
    Platform:
    GPL4126
    4 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE35312
    ID:
    200035312
    5.

    Integrative array-based approach identifies MZB1 as a frequently methylated putative tumor-suppressor in hepatocellular carcinoma (expression)

    (Submitter supplied) Gene expression was profiled using a 4x44K Human Whole Genome Ver. 2.0 gene expression array (Agilent Technologies) according to the manufacturer's instructions (Microarray-based gene expression analysis protocol ver. 5.0.1, Agilent Technologies)
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL4133
    16 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE35311
    ID:
    200035311
    6.

    Expression profiling of HCC

    (Submitter supplied) 61 human HCCs were analyzed for genome-wide gene expression. Samples were collected at two sites in Germany, Heidelberg (HD) and Hannover (N). The Heidelberg Collection include 40 independent HCC: 19 liver resections and 17 explant liver specimen (4 not determined); median age at surgery was 57 years (range, 16-78), and the male/female ratio was 3:1. All diagnoses were confirmed by histological reevaluation, and use of the samples was approved by the local ethics committee. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL14550
    80 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE50579
    ID:
    200050579
    7.

    Heterogeneity of gene-expression profiles of hepatocellular carcinoma tumors

    (Submitter supplied) BACKGROUND & AIMS: In approximately 70% of patients with hepatocellular carcinoma (HCC) treated by resection or ablation, disease recurs within 5 years. Although gene expression signatures have been associated with outcome, there is no method to predict recurrence based on combined clinical, pathology, and genomic data (from tumor and cirrhotic tissue). We evaluated gene expression signatures associated with outcome in a large cohort of patients with early stage (Barcelona-Clinic Liver Cancer 0/A), single-nodule HCC and heterogeneity of signatures within tumor tissues. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL18461
    69 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE56140
    ID:
    200056140
    8.

    Combining Clinical, Pathology, and Gene Expression Data to Predict Recurrence of Hepatocellular Carcinoma

    (Submitter supplied) Background: Hepatocellular carcinoma (HCC) is among the top-five cancer killers worldwide. Here, we describe our analysis of 20 gene signatures with reported prognostic value in a cohort of patients with early stage HCC treated with surgical resection. Methods: We performed gene-expression profiling of 164 formalin-fixed, paraffin-embedded HCC from three hepatology centers participating the HCC Genomic Consortium. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platforms:
    GPL18461 GPL8432 GPL5474
    620 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE20140
    ID:
    200020140
    9.

    Gene-expression profiles of formalin-fixed, paraffin-embedded human hepatocellular carcinoma

    (Submitter supplied) Gene-expression profiles of formalin-fixed, paraffin-embedded human hepatocellular carcinoma tissues obtained at the time of surgical resection.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL8432
    164 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE19977
    ID:
    200019977
    10.

    Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma (Validation Set)

    (Submitter supplied) Background: It is a challenge to identify those patients who, after undergoing potentially curative treatments for hepatocellular carcinoma, are at greatest risk of recurrence. Such high-risk patients could receive novel interventional measures. An obstacle to the development of genome-based predictors of outcome in patients with hepatocellular carcinoma has been the lack of a means to carry out genomewide expression profiling of fixed, as opposed to frozen, tissues. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL5474
    225 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE10142
    ID:
    200010142
    11.

    Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma (Training Set, HCC)

    (Submitter supplied) Background: It is a challenge to identify those patients who, after undergoing potentially curative treatments for hepatocellular carcinoma, are at greatest risk of recurrence. Such high-risk patients could receive novel interventional measures. An obstacle to the development of genome-based predictors of outcome in patients with hepatocellular carcinoma has been the lack of a means to carry out genomewide expression profiling of fixed, as opposed to frozen, tissues. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL5474
    80 Samples
    Download data:
    GEO (TXT, XLS)
    Series
    Accession:
    GSE10141
    ID:
    200010141
    12.

    Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma (Training Set, Liver)

    (Submitter supplied) Background: It is a challenge to identify those patients who, after undergoing potentially curative treatments for hepatocellular carcinoma, are at greatest risk of recurrence. Such high-risk patients could receive novel interventional measures. An obstacle to the development of genome-based predictors of outcome in patients with hepatocellular carcinoma has been the lack of a means to carry out genomewide expression profiling of fixed, as opposed to frozen, tissues. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL5474
    82 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE10140
    ID:
    200010140
    13.

    Gene expression profiling of 91 hepatocellular carcinomas with hepatitis C virus etiology

    (Submitter supplied) To characterize the genetic alterations that instigate hepatitis C virus-induced hepatocellular carcinoma (HCC), we conducted an integrative genomic analysis of 103 HCCs. Most tumors harbored 1q gain, 8q gain or 8p loss, with occasional alterations in 13 additional chromosome arms. In addition to amplifications at 11q13 in 6 tumors, 4 tumors harbored focal gains at 6p21 incorporating VEGFA, which were confirmed in 4 of 113 HCC in an independent validation set. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL570
    91 Samples
    Download data:
    GEO (CEL, TXT)
    Series
    Accession:
    GSE9843
    ID:
    200009843
    14.

    Gene expression data of human hepatocellular carcinoma (HCC)

    (Submitter supplied) We used Affymetrix microarray profiling to analyze gene expression patterns in healthy donor liver as well as tumor and paired non-tumor tissue of HCC patients.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platforms:
    GPL3921 GPL571
    488 Samples
    Download data:
    GEO (CEL, TXT)
    Series
    Accession:
    GSE14520
    ID:
    200014520
    15.

    ArrayCGH of human hepatocellular carcinoma (HCC)

    (Submitter supplied) We used array-based comparative genomic hybridization (arrayCGH) of 76 hepatocellular carcinomas (HCCs) to search for genetically disrupted genes.
    Organism:
    Homo sapiens
    Type:
    Genome variation profiling by array
    Platform:
    GPL4093
    76 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE14322
    ID:
    200014322
    16.

    Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips

    (Submitter supplied) We examine genome-wide DNA methylation profiles in 66 pairs of HCC tumor and adjacent non-tumor tissues. After Bonferroni adjustment, a total of 130,512 CpG sites significantly differed in methylation level in tumor compared to non-tumor tissues, with 28,017 CpG sites hypermethylated and 102,495 hypomethylated in tumor tissues. Most (60.1%) significantly hypermethylated CpG sites are located in CpG islands. more...
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by genome tiling array
    Platform:
    GPL13534
    132 Samples
    Download data:
    GEO (CSV)
    Series
    Accession:
    GSE54503
    ID:
    200054503
    17.

    Methylation in Taiwanese HCC tumor and adjacent tissues

    (Submitter supplied) We analyzed tumor and adjacent non-tumor tissues from 62 Taiwanese HCC cases using Illumina HumanMethylation 27 chips. After Bonferroni adjustment, a total of 2,324 CpG sites significantly differed in methylation level, with 684 CpG sites significantly hypermethylated and 1,640 hypomethylated in tumor compared to non-tumor tissues. Array data were validated with pyrosequencing in a subset of 5 of these genes; correlation coefficients ranged from 0.92 to 0.97.
    Organism:
    Homo sapiens
    Type:
    Methylation profiling by array
    Platform:
    GPL8490
    124 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE37988
    ID:
    200037988
    18.

    Expression data of hepatocellular carcinoma and adjacent liver tissues

    (Submitter supplied) To identify therapeutic targets with high specificity to HCC, we searched for genes significantly up-regulated in HCC over corresponding non-tumor liver using high-density microarrays Keywords: disease state analysis
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL5175
    20 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE12941
    ID:
    200012941
    19.

    Expression profiling of PBMC from patients with hepatocellular carcinoma

    (Submitter supplied) Aberrant gene expression analysis between peripheral blood mononuclear cell (PBMC) samples from healthy individuals and patients with pancreatic carcinoma, gastric carcinoma and hepatocellular carcinoma (HCC) were identified using Affymetrix gene arrays.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL570
    26 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE49515
    ID:
    200049515
    20.

    Nanomolar treatment with epigenetic drug combination induces genome-wide methylation and expression alterations in neuro-ectodermal cell lines

    (Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array; Methylation profiling by genome tiling array
    Platforms:
    GPL4126 GPL570
    88 Samples
    Download data:
    GEO (CEL, CHP, TXT)
    Series
    Accession:
    GSE35798
    ID:
    200035798

      Display Settings:

      Format
      Items per page
      Sort by

      Send to:

      Choose Destination

      Supplemental Content

      Find related data

      Recent activity

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...
      Write to the Help Desk