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    Results: 7

    1.

    Epstein-Barr virus maintains lymphomas via its miRNAs

    (Submitter supplied) Epstein‐Barr virus (EBV) has evolved exquisite controls over its host cells, human B lymphocytes, not only directing these cells during latency to proliferate and thereby expand the pool of infected cells, but also to survive and thereby persist for the lifetime of the infected individual. Although these activities ensure the virus is successful, they also make the virus oncogenic, particularly when infected people are immunosuppressed. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL10999
    4 Samples
    Download data:
    GEO (XLS), SRA SRP019222
    Series
    Accession:
    GSE44769
    ID:
    200044769
    2.

    The forced loss of Epstein Barr virus from Burkitt's lymphoma cells: uncomplemented cells vs BART miRNA complemented cells.

    (Submitter supplied) Transcriptional profiling of Burkitt lymphoma cells engineered to inducibly express dominant negative EBNA1 (dnEBNA1), which forces the loss of Epstein Barr virus (EBV). Profiles are made of cells in which all of EBV is lost (dnEBNA1 on) or all of EBV except the BART miRNAs is lost (dnEBNA1 on, BART miRNAs ectopically expressed).
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL4133
    6 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE22586
    ID:
    200022586
    3.

    The Epstein-Barr virus induced tumor suppressor miR-34a is growth promoting in EBV-infected B cells

    (Submitter supplied) Epstein-Barr virus (EBV) infection of primary human B cells drives their indefinite proliferation into lymphoblastoid cell lines (LCLs). B cell immortalization depends on expression of viral latency genes as well as the regulation of host genes. Given the important role of miRNAs in regulating fundamental cellular processes, in this study we assayed changes in host miRNA expression during primary B cell infection by EBV. more...
    Organism:
    Homo sapiens; Murid herpesvirus 1; Human herpesvirus 4; Mus musculus; Human herpesvirus 1; JC polyomavirus; Simian virus 40; Human immunodeficiency virus 1; Human herpesvirus 8; Murid herpesvirus 4; Rattus norvegicus; Human herpesvirus 5; BK polyomavirus
    Type:
    Non-coding RNA profiling by array
    Platform:
    GPL7722
    9 Samples
    Download data:
    GEO (GPR)
    Series
    Accession:
    GSE36926
    ID:
    200036926
    4.

    Gene expression changes in subclones of a Burkitt lymphoma cell line with different patterns of EBV latent infection

    (Submitter supplied) In this study we have investigated the gene expression profiles of three different types of subclone all generated by single cell cloning of the same parental EBV positive Burkitt lymphoma cell line Awia-BL. These included EBV negative clones which have lost the virus episome, EBV positive clones with a conventional Latency I form of infection and EBV positive clones with an atypical Wp-restricted form of infection.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL570
    12 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE42867
    ID:
    200042867
    5.

    The viral and cellular microRNA targetome in lymphoblastoid cell lines

    (Submitter supplied) Epstein-Barr virus (EBV) is a human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral oncogenesis. To date, a limited number of EBV miRNA targets have been identified; thus, the role of EBV miRNAs in viral pathogenesis is not well defined. more...
    Organism:
    Homo sapiens
    Type:
    Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing
    Platform:
    GPL10999
    11 Samples
    Download data:
    GEO (BED, TAB), SRA SRP016130
    Series
    Accession:
    GSE41437
    ID:
    200041437
    6.

    Expression of EBV miRNAs in numerous EBV-positive cell lines

    (Submitter supplied) EBV-positive cell lines were assayed for expression of EBV miRNAs. The names of the miRNAs are from miRBase from Fall 2007. Microarray probes are tandem complements of the mature miRNA sequence. We assayed Burkitt's lymphoma (BL), Nasopharyngeal carcinoma, post-transplant lymphoproliferative disease (PTLD), primary effusion lymphoma, and lymphoblastoid cell lines. We also assayed primary B cells that were infected with the B95-8 strain of EBV, which was found to express EBV miRNAs as early as 20 hours post infection. more...
    Organism:
    Homo sapiens; Arabidopsis thaliana; Human herpesvirus 4
    Type:
    Non-coding RNA profiling by array
    Platform:
    GPL7022
    48 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE12014
    ID:
    200012014
    7.

    Epstein-Barr virus growth/latency III program alters cellular microRNA expression

    (Submitter supplied) The Epstein-Barr virus (EBV) is associated with lymphoid and epithelial cancers. Initial EBV infection alters lymphocyte gene expression, inducing cellular proliferation and differentiation as the virus transitions through consecutive latency transcription programs. Cellular microRNAs (miRNAs) are important regulators of signaling pathways and are implicated in carcinogenesis. The extent to which EBV exploits cellular miRNAs is unknown. more...
    Organism:
    Homo sapiens
    Type:
    Non-coding RNA profiling by array
    Platform:
    GPL7422
    8 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE13056
    ID:
    200013056

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