Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

    Results: 20

    1.

    Gene expression changes in embryonic stem cells in response to Tcf15-E47

    (Submitter supplied) We set out to identify genes that respond rapidly to overexpression of a Tcf15-E47 heterodimeric transcription factor in mouse embryonic stem cells.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL6887
    12 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE42539
    ID:
    200042539
    2.

    Conversion of mES to cXEN cells

    (Submitter supplied) The inner cell mass of the mouse pre-implantation blastocyst is comprised of epiblast progenitor and primitive endoderm cells of which cognate embryonic (mESCs) or extra-embryonic (XEN) stem cell lines can be derived. Importantly, each stem cell type retains the defining properties and lineage restriction of their in vivo tissue of origin. Recently, we demonstrated that XEN-like cells arise within mESC cultures. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL6887
    8 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE38477
    ID:
    200038477
    3.

    Inactivation of Unr results in induction of differentiation of murine ES cells into the primitive endoderm lineage

    (Submitter supplied) Unr (upstream of N-ras) is a cytoplasmic RNA-binding protein with cold shock domains, involved in regulation of messenger RNA stability and translation. To address the biological role of Unr, we inactivated the unr gene by homologous recombination in mice and embryonic stem (ES) cells. Embryos deficient for Unr die at mid-gestation, and the main phenotypic defects observed, growth deficiency and absence of neural tube closure, suggest a role of Unr in the balance proliferation/differentiation during early development. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL339
    16 Samples
    Download data:
    GEO (CEL, CHP, EXP)
    Series
    Accession:
    GSE17566
    ID:
    200017566
    4.

    Heparan Sulfation Dependent FGF Signalling Maintains ES Cells Primed for Differentiation in a Heterogeneous State

    (Submitter supplied) Embryonic stem (ES) cells continuously decide whether to maintain pluripotency or differentiate. While exogenous LIF and BMP4 perpetuate a pluripotent state, less is known about factors initiating differentiation. We show that heparan sulfate (HS) proteoglycans are critical co-receptors for signals inducing ES cell differentiation. Genetic targeting of NDST1 and 2, two enzymes required for N-sulfation of proteoglycans, blocked differentiation. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL6885
    16 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE15974
    ID:
    200015974
    5.

    FGF inhibition directs BMP4-mediated differentiation of Human Embryonic Stem Cells to syncytiotrophoblast

    (Submitter supplied) Bone morphogenetic protein (BMP) signaling is known to support differentiation of human embryonic stem cells (hESCs) into mesoderm and extraembryonic lineages, whereas other signaling pathways can largely influence this lineage specification. Here, we set out to reinvestigate the influence of ACTIVIN/NODAL and fibroblast growth factor (FGF) pathways on the lineage choices made by hESCs during BMP4-driven differentiation. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL6883
    24 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE30125
    ID:
    200030125
    6.

    FGF2 sustains NANOG and switches the outcome of BMP4 induced human embryonic stem cell differentiation

    (Submitter supplied) NANOG has emerged as a central gatekeeper of pluripotency. Here we show that as human embryonic stem (ES) cells exit the pluripotent state, NANOG can play a key role in determining lineage outcome. It has previously been reported that BMPs can induce differentiation of human ES cells into extraembryonic lineages. Here we report that FGF2 switches BMP4 induced differentiation outcome to mesendoderm, characterized by the uniform expression of T (brachyury) and other primitive streak markers. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platforms:
    GPL6602 GPL9999
    50 Samples
    Download data:
    GEO (PAIR)
    Series
    Accession:
    GSE25973
    ID:
    200025973
    7.

    Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embyronic and induced pluripotent cells

    (Submitter supplied) Notch signaling regulates several cellular processes including cell fate decisions and proliferation in both invertebrates and mice. However, comparatively less is known about the role of Notch during early human development. Here, we examined the function of Notch signaling during hematopoietic lineage specification from human pluripotent stem cells (hPSCs) of both embryonic and adult fibroblast origin. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL96
    8 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE47466
    ID:
    200047466
    8.

    Expression data from porcine embryonic stem cells

    (Submitter supplied) We have been able to derive EpiSC-like pESC lines from in vivo produced porcine blastocysts. Our cell lines showed AP activity, expressions of the genes Oct4, Sox2, Nanog, Rex1, TDGF1, bFGF, FGFR1, FGFR2, Nodal and Activin-A involved in pluripotency and signaling pathways and in vitro differentiation potential, displaying similarities to epiblast stem cells or hES cells.
    Organism:
    Sus scrofa
    Type:
    Expression profiling by array
    Platform:
    GPL3533
    3 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE32506
    ID:
    200032506
    9.

    H9 hES cells vs. universal RNAs

    (Submitter supplied) Comparison of human embryonic stem cell transcriptome with universal RNA pool (10 human cell lines) to reveal hES cell-specific gene expression. Keywords: cell type comparison
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL2507
    2 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE5423
    ID:
    200005423
    10.

    Knock-down of three core transcription factors in hEC cells

    (Submitter supplied) Three transcription factors were silenced in human embryonic carcinoma cells, OCT4, NANOG, and SOX2. Downstream effects were analysed by means of microarrays to obtain insights into the regulation of self-renewal in these cells. Keywords: RNAi-chip
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL2507
    4 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE5422
    ID:
    200005422
    11.

    Gene Expression Analysis of Sox17-induced Mouse Embryonic Stem Cells

    (Submitter supplied) To determine the effect of Sox17 overexpression in mouse embryonic stem (ES) cells, we performed gain-of-function analysis by generating ES cell lines carrying a doxycycline inducible FLAG-tagged Sox17 transgene. We treated Sox17-inducible ES cells with doxycycline, collected RNA and performed genome-wide transcriptional analysis. We found that genes invovled in adhesion function and basement membrane establishment were transcriptionally upregulated in ES cells upon induction of Sox17. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL6885
    6 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE19028
    ID:
    200019028
    12.

    Genome-Wide Sox17 Binding Sites in Mouse Extraembryonic Endoderm and Embryonic Stem Cells

    (Submitter supplied) We investigated whether Sox17 directly or indirectly regulates extraembryonic endoderm gene expression by identifying Sox17 DNA-binding sites using chromatin-immunoprecipitation coupled with whole-genome promoter tiling array analysis (ChIP-Chip). We used the Sox17 and FLAG antibody to ask whether Sox17 was binding directly to the regulatory regions of genes in homogeneous extraembryonic endoderm (XEN) cell lines and in Sox17-inducible mouse embryonic stem (ES) cells. more...
    Organism:
    Mus musculus
    Type:
    Genome binding/occupancy profiling by genome tiling array
    Platform:
    GPL5811
    3 Samples
    Download data:
    GEO (BAR, CEL)
    Series
    Accession:
    GSE19026
    ID:
    200019026
    13.

    Induced overexpression of Pdx1 and Ngn3 in a mouse ES cell-derived endoderm population induces pancreatic differentiation

    (Submitter supplied) Induced overexpression of Pdx1 in activin-induced endoderm population resulted in the upregulation of pancreas-related genes such as insulin 1 and 2 at day 20. To enhance the developmental progression from the pancreatic bud to the formation of the endocrine lineages, we next expressed neurogenin3 (Ngn3) together with Pdx-1. Induced overexpression of Pdx1 together with Ngn3 dramatically increased Insulin 1 mRNA by day 9 differentiation. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL2897
    10 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE23752
    ID:
    200023752
    14.

    Expresion profile of MEF reprogrammed with Yamanaka´s factor together with FoxA2 and Gata4

    (Submitter supplied) In a pilot experiment to reprogramme MEF into endoderm, we infected MEF with the Yamanaka´s factors (O: Oct4, K: Klf4, S: Sox2, M:Myc), FoxA2 (F) and Gata4 (G). Global gene expression of isolated clones was performed.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL6246
    13 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE37548
    ID:
    200037548
    15.

    A distinct microRNA signature for definitive endoderm derived from human embryonic stem cells

    (Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
    Organism:
    Homo sapiens
    Type:
    Non-coding RNA profiling by array; Expression profiling by array
    Platforms:
    GPL8733 GPL7363
    29 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE16690
    ID:
    200016690
    16.

    MicroRNA expression data from differentiation of human H9 ESCs into definitive endoderm on MEF feeder layers

    (Submitter supplied) Pluripotent hESCs can differentiate into the three primary embryonic lineages (endoderm, mesoderm, ectoderm) as well as extraembryonic tissues. Definitive endoderm (DE) is the first step into the pathway to endoderm dreived tissues (pancreas, liver, gut, lung). We used microarrays to detail the changes in microRNA expression during the transition from pluripotent hESCs into definitive endoderm.
    Organism:
    Homo sapiens
    Type:
    Non-coding RNA profiling by array
    Platform:
    GPL8733
    6 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE16689
    ID:
    200016689
    17.

    MicroRNA expression data from differentiation of human Cyt49 ESCs into definitive endoderm on MEF feeder layers

    (Submitter supplied) Pluripotent hESCs can differentiate into the three primary embryonic lineages (endoderm, mesoderm, ectoderm) as well as extraembryonic tissues. Definitive endoderm is the first step into the pathway to endoderm dreived tissues (pancreas, liver, gut, lung) We used microarrays to detail the changes in microRNA expression during the transition from pluripotent hESCs into definitive endoderm
    Organism:
    Homo sapiens
    Type:
    Non-coding RNA profiling by array
    Platform:
    GPL8733
    6 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE16687
    ID:
    200016687
    18.

    mRNA expression data from differentiation of human ESCs into definitive endoderm, Cyt49 on matrigel

    (Submitter supplied) hESCs can differentiate into the three primary embryonic lineages (endoderm, mesoderm, ectoderm) as well as extraembryonic tissues. Definitive endoderm (DE) is the first step into the pathway to endoderm derived tissues: pancreas, liver, gut, lung. We used microarrays to detail the changes in mRNA expression during the transition from pluripotent hESCs into definitive endoderm.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL7363
    9 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE16681
    ID:
    200016681
    19.

    MicroRNA expression data from differentiation of human Cyt49 ESCs into definitive endoderm in feeder-free conditions

    (Submitter supplied) Pluripotent hESCs can differentiate into the three primary embryonic lineages (endoderm, mesoderm, ectoderm) as well as extraembryonic tissues. Definitive endoderm is the first step into the pathway to endoderm dreived tissues (pancreas, liver, gut, lung). We used microarrays to detail the changes in microRNA expression during the transition from pluripotent hESCs into definitive endoderm.
    Organism:
    Homo sapiens
    Type:
    Non-coding RNA profiling by array
    Platform:
    GPL8733
    8 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE16678
    ID:
    200016678
    20.

    Global gene expression analysis of PB-Oct4.2A.cherry iPS-/-, PB-Oct4.2A.cherry (low) iPS-/- and ES cells

    (Submitter supplied) We have generated iPS cell lines with constitutive Oct4 expression at ES-cell level or 3 times lower. The aim of the experiment was to compare the global gene expression profile between these two cell lines and also between each of them and wild type ES cells.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL6887
    6 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE45003
    ID:
    200045003

      Display Settings:

      Format
      Items per page
      Sort by

      Send to:

      Choose Destination

      Supplemental Content

      db=gds|term=|query=1|qty=3|blobid=NCID_1_107222355_130.14.18.34_9001_1435858287_1083706869_0MetA0_S_MegaStore_F_1|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
         Taxonomic Groups  [List]
      Tree placeholder
          Top Organisms  [Tree]

      Find related data

      Recent activity

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...
      Write to the Help Desk