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    Results: 4

    1.

    Identification of microRNAs specifically expressed in HCV-associated hepatocellular carcinoma

    (Submitter supplied) Background: Several studies have investigated the association of miRNAs with hepatocellular carcinoma (HCC) but the data are not univocal. Methods: We performed a microarray study of miRNAs in hepatitis C virus (HCV)-associated HCC and other liver diseases and healthy conditions. Results and Conclusions: The simultaneous comparison of different liver diseases and normal livers allowed the identification of 18 miRNAs exclusively expressed in HCV-associated HCC, with sensitivity and specificity values of diagnostic-grade.
    Organism:
    Homo sapiens; synthetic construct
    Type:
    Non-coding RNA profiling by array
    Platform:
    GPL14613
    76 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE40744
    ID:
    200040744
    2.

    RMA expression data for liver samples from subjects with HCV, HCV-HCC, or normal liver

    (Submitter supplied) The role of chronic hepatitis C virus (HCV) in the pathogenesis of HCV-associated hepatocellular carcinoma (HCC) is not completely understood, particularly at the molecular level. We studied gene expression in normal, pre-malignant (cirrhosis), and tumor (HCC) liver tissues using Affymetrix GeneChips. Keywords: cross-sectional
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platforms:
    GPL96 GPL571
    124 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE14323
    ID:
    200014323
    3.

    Gene expression profiling of hepatitis B- and hepatitis C-related hepatocellular carcinoma using graphical Gaussian modeling

    (Submitter supplied) Gene expression profiling of hepatocellular carcinoma (HCC) and background liver has been studied extensively; however, the relationship between the gene expression profiles of different lesions has not been assessed. We examined the expression profiles of 34 HCC specimens (17 hepatitis B virus [HBV]-related and 17 hepatitis C virus [HCV]-related) and 71 non-tumor liver specimens (36 chronic hepatitis B [CH-B] and 35 chronic hepatitis C [CH-C]) using an in-house cDNA microarray consisting of liver-predominant genes. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL13536
    105 Samples
    Download data:
    GEO (GPR)
    Series
    Accession:
    GSE44074
    ID:
    200044074
    4.

    Aberrant DNA methylation in hepatitis B and C virus-related hepatocellular carcinoma

    (Submitter supplied) Chronic infections by hepatitis B virus (HBV) and hepatitis C virus (HCV) appear to be the most significant causes of hepatocellular carcinoma (HCC). Aberrant promoter methylation is known to be deeply involved in cancer, including HCC. In this study, we analyzed aberrant promoter methylation on genome-wide scale in 6 HCCs including 3 HBV-related and 3 HCV-related HCCs, 6 matched noncancerous liver tissues and 3 normal liver tissues by methylated DNA immunoprecipitation-on-chip analysis. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL570
    20 Samples
    Download data:
    GEO (CEL, TXT)
    Series
    Accession:
    GSE19665
    ID:
    200019665

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