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    Results: 6

    1.

    Global gene expression analysis of the zoonotic parasite Trichinella spiralis revealed novel genes in host parasite interaction

    (Submitter supplied) Trichinellosis of human and other mammals was caused through the ingestion of the parasite,Trichinella spiralis,contaminated meat. It is a typical zoonotic disease that affects more than 10 million people world-wide. Parasites of Trichinella genus are unique intracellular pathogens. Adult Trichinella parasites directly release newborn larvae which invade striated muscle cells and causes diseases. In this study, we profiled the global transcriptome in the three developmental stages of T. more...
    Organism:
    Trichinella spiralis
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL15773
    3 Samples
    Download data:
    GEO (TXT), SRA SRP014138
    Series
    Accession:
    GSE39151
    ID:
    200039151
    2.

    S.japonicum Digital Gene Expression

    (Submitter supplied) Schistosoma japonicum is one of the remarkable platyhelminths that are endemic in the South Asian countries. The parasite is dioecious and can parasitize inside host blood stream for many years. Rapid reproduction by producing large number of eggs and count-react or active manipulating host anti-parasite responses are the strategies that benefit the long term parasitization of the parasite. Currently, Praziquantel is the only commercial drug that is effective against the worms but not the eggs of parasite in the host and no vaccine available to prevent human or animal schistosomiasis. more...
    Organism:
    Schistosoma japonicum
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL11650
    2 Samples
    Download data:
    GEO, SRA SRP005478
    Series
    Accession:
    GSE26845
    ID:
    200026845
    3.

    Transcriptome analysis of two life cycle stages of Trypanosoma brucei gambiense

    (Submitter supplied) Trypanosoma brucei gambiense is the causative agent of the fatal human disease African sleeping sickness. Here we have compared the transcriptome of two different life cycle stages, the potentially human-infective bloodstream form and the non-human-infective procyclic stage, using digital gene expression (DGE) analysis.
    Organism:
    Trypanosoma brucei gambiense
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL9247
    6 Samples
    Download data:
    GEO, SRA SRP001797
    Series
    Accession:
    GSE18065
    ID:
    200018065
    4.

    Differential methylation in discrete developmental stages of the parasitic nematode Trichinella spiralis

    (Submitter supplied) We present the first study to confirm the existence of DNA methylation in the parasitic nematode Trichinella spiralis, and we characterize the methylomes of the three life-cycle stages of this food-borne infectious human pathogen. We observe a drastic increase in DNA methylation during the transition from the new born to mature stage, and we further identify parasitism-related genes that show changes in DNA methylation status between life cycle stages. more...
    Organism:
    Trichinella spiralis
    Type:
    Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing
    Platforms:
    GPL15773 GPL15806
    6 Samples
    Download data:
    GEO (TXT), SRA SRP014316
    Series
    Accession:
    GSE39328
    ID:
    200039328
    5.

    Dual RNA-seq of parasite and host reveals gene expression dynamics during filarial worm-mosquito interactions

    (Submitter supplied) Parasite biology, by its very nature, cannot be understood without integrating it with that of the host, nor can the host response be adequately explained without considering the activity of the parasite. However, due to experimental limitations, molecular studies of parasite-host systems have been predominantly one-sided investigations focusing on either of the partners. Here we conduct a joint dual RNA-seq time course analysis of filarial parasite and host mosquito to better understand the parasite processes underlying development in, and interaction with, the host tissue from the establishment of infection to the emergence of infective-stage larva. more...
    Organism:
    Aedes aegypti
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL14869
    38 Samples
    Download data:
    GEO (TXT), SRA SRP034735
    Series
    Accession:
    GSE53664
    ID:
    200053664
    6.

    Simultaneous gene expression profiling in human macrophages infected with Leishmania major parasites using SAGE

    (Submitter supplied) Leishmania (L) are intracellular protozoan parasites which are able to survive and replicate within the harsh and potentially hostile phago-lysosomal environment of mammalian mononuclear phagocytes. A complex interplay then takes place between the macrophage (MΦ) striving to eliminate the pathogen and the parasite struggling for its own survival. To investigate, at the transcriptional level, this host-parasite conflict in the context of monocyte-derived human MΦs (MDM) infection by L. more...
    Organism:
    Homo sapiens; Leishmania major
    Type:
    Expression profiling by SAGE
    Platforms:
    GPL4 GPL6471
    3 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE10442
    ID:
    200010442

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