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    Results: 7

    1.

    Genome-wide profiling of altered gene expression in the neocortex of Alzheimer's disease (gene level)

    (Submitter supplied) We investigated genome-wide gene alterations in the temporal cortex of a well-characterized cohort of Alzheimer’s disease (AD) patients using Affymetrix exon arrays.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL5175
    16 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE37263
    ID:
    200037263
    2.

    Gene expression data from temporal cortex of young adult, old and AD-like Microcebus murinus

    (Submitter supplied) Aging is the primary risk factor of neurodegenerative disorders such as Alzheimer's disease (AD). However, the molecular events occurring during brain aging are extremely complex and still largely unknown. For a better understanding of these age-associated modifications, animal models as close as possible to humans are needed. We thus analyzed the transcriptome of the temporal cortex of the primate Microcebus murinus using human oligonucleotide microarrays (Affymetrix). more...
    Organism:
    Homo sapiens; Microcebus murinus
    Type:
    Expression profiling by array
    Dataset:
    GDS4128
    Platform:
    GPL570
    18 Samples
    Download data:
    GEO (CEL, CHP)
    Series
    Accession:
    GSE21779
    ID:
    200021779
    3.
    Full record GDS4128

    Model of cerebral aging and Alzheimer's disease: temporal cortex

    Analysis of temporal cortex of young adult, old healthy, and Alzheimer’s disease (AD-like) animals. AD-like animals presented ß-amyloid plaques and cortical atrophy, which are signs of AD in humans. Results provided insight into molecular basis of physiological versus pathological brain aging.
    Organism:
    Homo sapiens; Microcebus murinus
    Type:
    Expression profiling by array, count, 2 age, 2 disease state, 2 gender sets
    Platform:
    GPL570
    Series:
    GSE21779
    18 Samples
    Download data:
    GEO (CEL, CHP)
    4.

    mRNA and miRNA expression in parietal lobe cortex in Alzheimer's disease

    (Submitter supplied) In this study, we jointly profiled mRNA and miRNA expression to determine the role of miRNAs in AD, and whether the levels of miRNAs are related to those of target mRNAs. We found a bias towards positive correlation between levels of miRNAs and those of their targets.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array; Non-coding RNA profiling by array
    Platforms:
    GPL570 GPL8757
    16 Samples
    Download data:
    GEO (CEL, XLS)
    Series
    Accession:
    GSE16759
    ID:
    200016759
    5.

    Evaluation of gene expression profile in postmortem brain with Alzheimer´s disease-type neuropathological changes

    (Submitter supplied) Unravel the mechanisms underlying brain aging and Alzheimer´s disease (AD) has been difficult because of complexity of the networks that drive these aging-related changes. Analysis of the gene expression in the brain is a valuable tool to study the function of the brain under normal and pathological conditions. Gene microarray technology allows massively parallel analysis of most genes expressed in a tissue, and therefore is an important research tool that potentially can provide the investigative power needed to address the complexity of brain aging and neurodegenerative processes. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL1930
    128 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE13214
    ID:
    200013214
    6.

    Brain microvessel: Alzheimer disease vs normal

    (Submitter supplied) The enigma that is Alzheimer's disease (AD) continues to present daunting challenges for effective therapeutic intervention. The lack of disease-modifying therapies may, in part, be attributable to the narrow research focus employed to understand this complex disease. Most studies into disease pathogenesis are based on a priori assumptions about the role of AD lesion-associated proteins such as amyloid-β and tau. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL4133
    20 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE45596
    ID:
    200045596
    7.

    Expression data of FFPE peritumoral neocortex tissue

    (Submitter supplied) Epilepsy is a common cause of morbidity affecting approximately one third of patients with primary brain tumors. However, the molecular mechanism underlying the tumor induced epileptogenesis is poorly understood. The alteration in peritumoral microenvironments is believed to play a significant role in inducing epileptogenesis. We hypothesize that the change of gene expression in neighboring astrocytes and neurons may contribute to the increased neuronal excitability and epileptogenesis.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL570
    10 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE32534
    ID:
    200032534

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