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    Results: 19

    1.

    microRNA profiling in paired human prostate cancer and benign prostate tissue

    (Submitter supplied) To determine the altered microRNA expression signature in human prostate cancer compared to benign prostate tissue. To determine the altered mRNA expression signatures upon overexrpession miR-31 in prostate cancer cells.
    Organism:
    synthetic construct; Homo sapiens
    Type:
    Non-coding RNA profiling by array
    Platform:
    GPL8786
    42 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE36802
    ID:
    200036802
    2.

    Paired human prostate cancer and benign prostate tissues, and LNCaP cells treated with miR-31

    (Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
    Organism:
    synthetic construct; Homo sapiens
    Type:
    Expression profiling by array; Non-coding RNA profiling by array
    Platforms:
    GPL8786 GPL10558
    46 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE36803
    ID:
    200036803
    3.

    mRNA profiling of LNCaP cells treated with miR-31

    (Submitter supplied) To determine the altered microRNA expression signature in human prostate cancer compared to benign prostate tissue. To determine the altered mRNA expression signatures upon overexrpession miR-31 in prostate cancer cells.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL10558
    4 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE36801
    ID:
    200036801
    4.

    Global methylation analysis identifies PITX2 as an upstream regulator of the androgen receptor and IGF-I receptor genes in prostate cancer

    (Submitter supplied) The insulin-like growth factor-I (IGF-IR) and androgen (AR) receptors are important players in prostate cancer biology. Functional interactions between the IGF-I and androgen signaling pathways seem to have crucial roles in the progression of prostate cancer from early (benign) to advanced (metastatic) stages. DNA methylation is a major epigenetic alteration affecting gene expression. Hypermethylation of tumor suppressor promoters is a frequent event in human cancer, leading to inactivation and repression of specific genes. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL570
    12 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE34042
    ID:
    200034042
    5.

    SABiosciences Human miRNA PCR array assay of normal respiratory epithelia and lung cancer cells with or without treatment of CSC

    (Submitter supplied) MicroRNAs are critical mediators of stem cell pluripotency, differentiation and malignancy. Limited information exists regarding microRNA alterations that facilitate initiation and progression of human lung cancers. In this study, array techniques were used to evaluate microRNA expression in normal human respiratory epithelia and lung cancer cells cultured in the presence or absence of cigarette smoke condensate (CSC). more...
    Organism:
    Homo sapiens
    Type:
    Other
    Platform:
    GPL16382
    8 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE42962
    ID:
    200042962
    6.

    Identification of miR-205 targets using an RIP-Chip assay with AGO2 antibody

    (Submitter supplied) In this study, the prognostic properties of miR-205 expression levels are investigated in a well-documented prostate cancer cohort. We show that miR-205 is correlated to shortened overall survival, significantly dividing the PCa patients into high and low risk groups. Furthermore, miR-205 is shown to inversely correlate to occurrence of metastases. In situ hybridization is also performed, demonstrating high miR-205 expression in the basal cells of benign prostate tissue glands. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array; Other
    Platform:
    GPL6244
    6 Samples
    Download data:
    GEO (CEL, CHP)
    Series
    Accession:
    GSE39735
    ID:
    200039735
    7.

    Expression data comparing LNCaP cells infected with miR-616 vs. empty vector control

    (Submitter supplied) To identify candidate downstream mRNA target(s) for hsa-miR-616 Affymetrix Human Genome U133 Plus GeneChip 2.0
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL570
    2 Samples
    Download data:
    GEO (CEL, CHP)
    Series
    Accession:
    GSE20543
    ID:
    200020543
    8.

    Gene expression in human prostate cancer cell lines regulated by HIC1 gene

    (Submitter supplied) This study aimed to further our understanding of the role that hypermethylatioted in cancer 1 (HIC1) plays in prostate cancer (PCa) development. Microarrays were searched for some genes that had correlated expression with HIC1 mRNA. Our data showed that HIC1 promoter hypermethylation was presented in cell lines, tissues and plasma of PCa patients. According to fold-change screening between restoring expression of HIC1 and its respective control cells, both up-regulated and down-regulated genes were commonly observed in PC3 and C4-2B cells.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL6480
    4 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE42336
    ID:
    200042336
    9.

    Profiling of direct mRNA targets of miR-130a, miR-203 and miR-205 in prostate cancer cell line LNCaP

    (Submitter supplied) Micro RNAs (miRNAs) miR-130a, miR-203 and miR-205 are jointly downregulated in prostate cancer and act as repressors of AR-signaling. MiRNAs are small non-coding RNAs that regulate the expression of specific mRNA targets mainly by translational repression, mRNA deadenylation or cleavage. Reconstitution of these lost miRNAs in the LNCaP PCa cell line cause morphology changes, growth arrest, and apoptosis, increasing when the miRNAs were co-expressed. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL571
    24 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE22979
    ID:
    200022979
    10.

    miRNA expression, mRNA expression upon miRNA reconstitution, and direct mRNA target identification in prostate cancer cell lines

    (Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array; Non-coding RNA profiling by array
    Platforms:
    GPL8899 GPL571
    48 Samples
    Download data:
    GEO (CEL, GPR)
    Series
    Accession:
    GSE17362
    ID:
    200017362
    11.

    miRNA expression in LNCaP, PC3, Du-145 and RWPE-1 cell lines

    (Submitter supplied) MiRNAs are small non-coding RNAs that regulate the expression of specific mRNA targets mainly by translational repression, mRNA deadenylation or cleavage. This series is meant to identify miRNAs deregulated in prostate cancer (PCa) by comparing the PCa cell lines LNCaP, PC3 and Du-145 to the normal prostate epithelial cell line RWPE-1.
    Organism:
    Homo sapiens
    Type:
    Non-coding RNA profiling by array
    Platform:
    GPL8899
    12 Samples
    Download data:
    GEO (GPR)
    Series
    Accession:
    GSE17317
    ID:
    200017317
    12.

    mRNA expression upon reconstitution of miR-130a, miR-203 and miR-205 in prostate cancer cell line LNCaP

    (Submitter supplied) Micro RNAs (miRNAs) miR-130a, miR-203 and miR-205 are jointly downregulated in prostate cancer and act as repressors of AR-signaling. MiRNAs are small non-coding RNAs that regulate the expression of specific mRNA targets mainly by translational repression, mRNA deadenylation or cleavage. Reconstitution of these lost miRNAs in the LNCaP PCa cell line cause morphology changes, growth arrest, and apoptosis, increasing when the miRNAs were co-expressed. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL571
    12 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE17315
    ID:
    200017315
    13.

    Human prostate cancer xenografts on intact mice or after castration.

    (Submitter supplied) cDNA expression arrays on a panel of human prostate cancer xenografts. The xenografts can divided into three groups: 1) androgen-dependent, 2) androgen-independent with functional expression of the androgen receptor, 3) androgen-independent lacking functional expression of the androgen receptor. Four microarrays were performed per xenograft using tissue samples collected in separate experiments. Two samples were taken from intact male mice, whereas the other two samples were taken 1 to 2 weeks after castration. more...
    Organism:
    Mus musculus; Homo sapiens
    Type:
    Expression profiling by array
    Dataset:
    GDS2384
    Platform:
    GPL3349
    52 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE4084
    ID:
    200004084
    14.

    Prostate cancer cell line LNCaP treated for 2, 4, 6, 8 h with the synthetic androgen R1881 (1nM)

    (Submitter supplied) Time series of the prostate cancer cell line LNCaP, treated for 2, 4, 6 and 8 hours with the synthetic androgen R1881. As control, the cells were cultured for 2, 4, 6 and 8 hours in the presence of the same concentration of solvent (ethanol). With this short treatment time, we aimed to identify mainly direct targets of the androgen receptor. LNCaP has a very low growth rate in steroid stripped medium and resumes growth on addition of androgens. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Dataset:
    GDS2034
    Platform:
    GPL3349
    8 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE4027
    ID:
    200004027
    15.
    Full record GDS2384

    Xenograft model of prostate carcinoma progression

    Analysis of prostate cancer (PC) xenografts collected from male mice up to 14 days after castration. The androgen receptor (AR) plays a pivotal role in the growth and survival of prostate carcinoma. Results provide insight into the role of selective adaptations of the AR pathway in PC progression.
    Organism:
    Homo sapiens; Mus musculus
    Type:
    Expression profiling by array, log2 ratio, 4 disease state, 3 other, 10 protocol, 14 specimen sets
    Platform:
    GPL3349
    Series:
    GSE4084
    52 Samples
    Download data:
    GEO
    DataSet
    Accession:
    GDS2384
    ID:
    2384
    16.
    Full record GDS2034

    Prostate cancer cell line LNCaP response to synthetic androgen R1881: time course

    Expression profiling of prostate cancer cell line LNCaP treated for up to 8 hours with the synthetic androgen R1881. LNCaP cells grow slowly in medium devoid of steroids but resume growth upon the addition of androgens. The study aims to identify direct targets of the androgen receptor.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, log2 ratio, 4 time sets
    Platform:
    GPL3349
    Series:
    GSE4027
    8 Samples
    Download data:
    GEO
    DataSet
    Accession:
    GDS2034
    ID:
    2034
    17.

    Bypass mechanisms of the AR pathway in castration-resistant PC346 prostate cancer cells

    (Submitter supplied) Prostate cancer is initially dependent on androgens for survival and growth, making hormonal therapy the cornerstone treatment for invasive tumors. However, despite initial remission, the cancer will inevitably recur. The present study was set to investigate how androgen-dependent prostate cancer cells eventually survive and resume growth under androgen-deprived and antiandrogen supplemented conditions Microarray technology was used to analyze differences in gene expression between androgen-responsive and hormone-refractory prostate cancer cell lines. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL10367
    12 Samples
    Download data:
    GEO (TIFF, TXT)
    Series
    Accession:
    GSE21596
    ID:
    200021596
    18.

    Dysregulation of cholesterol homeostasis in human prostate cancer through loss of ABCA1

    (Submitter supplied) We conducted gene expression profilling of common prostate cell lines for comparison with genome-wide DNA methylation profiles for the same cell lines to study the impact of differential DNA methylation in prostate cancer.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL6883
    12 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE35401
    ID:
    200035401
    19.

    Real-time quantitative PCR analysis of DZNep treated B cell Lymphoma cell line Jeko-1

    (Submitter supplied) Jeko-1 cells were culture with or without PRC2 inhibitor 3-deazaneplanocin A (DZNep)(1uM) for 72hrs. We used TaqMan® Human MicroRNA Array to quantitate miRNA expression profile regulated by PRC2.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by RT-PCR
    Platform:
    GPL15919
    4 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE40019
    ID:
    200040019

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