Similar studies for GEO DataSets (Select 200030247) - GEO DataSets

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Items: 3

Select item 2000302471.

High Fat Diet Triggers SIRT1 Cleavage in Adipose Tissue Providing a Link between Dietary Stress and Metabolic Dysfunction.

(Submitter supplied) Adipose tissue plays an important role in storing excess nutrients and preventing ectopic lipid accumulation in other organs. Obesity leads to excess lipid storage in adipocytes, resulting in the generation of stress signals and the derangement of metabolic functions. SIRT1 is an important regulatory sensor of nutrient availability in many metabolic tissues. Here we report that SIRT1 functions in adipose tissue to protect from the development of inflammation and obesity under normal feeding conditions, and the progression to metabolic dysfunction under dietary stress. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
16 Samples

Download data: CEL

Series

Accession:: GSE30247

ID:: 200030247

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000397782.

Role of SIRT1 in diet-induced metabolic diseases

(Submitter supplied) The purpose of this study is to investigate the role of SIRT1 in high-fat diet-induced liver steatosis and insulin resistance. SIRT1 is a nuclear enzyme that could remove an acetyl-group from target proteins by using NAD as co-substrate. Homologs of this protein in yeast and the roundworm C. elegans are able to delay the aging process in response to nutrients. However, the molecular mechanism by which SIRT1 sense the environment to mediate this response are poorly understood. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL4134
12 Samples

Download data: TXT

Series

Accession:: GSE39778

ID:: 200039778

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000641043.

SUCNR1-mediated chemotaxis of macrophages aggravates obesity-induced inflammation and diabetes.

(Submitter supplied) Obesity induces macrophages to drive inflammation in adipose tissue, a crucial step towards the development of type 2 diabetes. The tricarboxylic acid (TCA) cycle intermediate succinate is released from cells under metabolic stress and has recently emerged as a metabolic signal induced by proinflammatory stimuli. We therefore investigated whether succinate receptor 1 (SUCNR1) could play a role in the development of adipose tissue inflammation and type 2 diabetes. more...