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    Results: 11

    1.

    Identification of C/EBPβ Target Genes in ALK+ Anaplastic Large Cell Lymphoma (ALCL) by Gene Expression Profiling and Chromatin Immunoprecipitation

    (Submitter supplied) C/EBPβ (CCAAT enhancer binding protein) is a transcription factor that plays a crucial role in survival and transformation of ALK+ anaplastic large cell lymphoma (ALCL). The aim of this study was to identify the downstream targets of C/EBPβ responsible for ALK-mediated oncogenesis. C/EBPβ was knocked down in ALK+ ALCL cell lines with a C/EBPβ-shRNA, followed by gene expression profiling (GEP). GEP analysis revealed a reproducible signature of genes that were significantly regulated by C/EBPβ. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL570
    14 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE23368
    ID:
    200023368
    2.

    Anaplastic Lymphoma Kinase signature

    (Submitter supplied) Anaplastic Large Cell Lymphomas (ALCL) represent a subset of lymphomas in which the Anaplastic Lymphoma Kinase (ALK) gene is frequently fused to the NPM gene. We previously demonstrated that the constitutive phosphorylation of ALK chimeric proteins is sufficient to induce cellular transformation in vitro and in vivo, and that ALK activity is strictly required for the survival of ALK positive ALCL cells. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL96
    33 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE6184
    ID:
    200006184
    3.

    Gene expression study of anaplastic large cell lymphomas: cellular origin, pathogenesis and relation to Hodgkin lymphoma

    (Submitter supplied) Anaplastic large cell lymphoma (ALCL) is a main type of T cell lymphomas and comprises three distinct entities: systemic ALK+, systemic ALK- and cutaneous ALK- ALCL. Little is known about their pathogenesis and their cellular origin, and morphological and immunophenotypical overlap exists between ALK- ALCL and classical Hodgkin lymphoma (cHL). We conducted gene expression profiling of microdissected lymphoma cells of ALK+ and ALK- systemic ALCL, cutaneous ALCL and cHL, and of eight subsets of normal T and NK cells. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL570
    64 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE14879
    ID:
    200014879
    4.

    Common features and differences in the transcriptome of large cell anaplastic lymphoma and classical Hodgkin lymphoma

    (Submitter supplied) Analysis of differential gene expression in human non-Hodgkin`s lymphoma cell lines and a primary leukaemic tumor sample of large cell anaplastic type in comparison with Hodgkin`s lymphoma cell lines and other non-Hodgkin`s lymphoma samples and non-neoplastic lymphocytes Keywords: cell type comparison
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL91
    4 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE4109
    ID:
    200004109
    5.

    Gene expression profiling of C/EBPβ- and STAT3-deficient human endometrial stromal cells (HESC)

    (Submitter supplied) Our previous studies have shown that C/EBPβ plays a critical role in human endometrial stromal decidualization. In order to identify the molecular pathways regulated by C/EBPβ during decidualization, we performed gene expression profiling using RNA isolated from normal and C/EBPβ-deficient human endometrial stromal cells. The microarray results revealed that several key regulators of stromal differentiation, such as BMP2, Wnt4, IL-11Rα and STAT3, operate downstream of C/EBPβ during decidualization. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL571
    8 Samples
    Download data:
    GEO (CEL, CHP)
    Series
    Accession:
    GSE41473
    ID:
    200041473
    6.

    Transcriptional signature of C/EBPBeta in Hep3B cells: Involvement of the LAP and LIP isoforms in hepatocarcinogenesis

    (Submitter supplied) C/EBPβ plays a major role in numerous biological processes but unfortunately its precise role is not still clear and conflicting studies showed that this transcription factor could have contradictory functions. These latter arise from the complexity of mechanisms regulating C/EBPβ activity. Indeed, C/EBPβ encodes an intronless gene that generates a single mRNA that is alternatively translated into two major isoforms of 35kDa (liver-enriched activator protein: LAP) and 20kDa (liver-enriched inhibitory protein: LIP). more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL5215
    20 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE12410
    ID:
    200012410
    7.

    Genomic profiling of Anaplastic Large Cell Lymphoma

    (Submitter supplied) Anaplastic Large Cell Lymphoma (ALCL) is a mature T-cell lymphoma that can present as a systemic or primary cutaneous disease. Systemic ALCL represents 2-5% of adult lymphoma but up to 30% of all pediatric cases. Two subtypes of systemic ALCL are currently recognized on the basis of the presence of a translocation involving the Anaplastic Lymphoma Kinase ALK gene. Despite considerable progress, several questions remain open regarding the pathogenesis of both ALCL subtypes. more...
    Organism:
    Homo sapiens
    Type:
    Genome variation profiling by SNP array; SNP genotyping by SNP array
    Platform:
    GPL6801
    70 Samples
    Download data:
    GEO (CEL, TXT)
    Series
    Accession:
    GSE50253
    ID:
    200050253
    8.

    Genomic profiling of Richter-syndrome Chronic Lymphocytic Leukemia

    (Submitter supplied) Richter syndrome (RS) occurs in up to 15% of patients with chronic lymphocytic leukemia (CLL). While RS, usually represented by the histologic transformation to a diffuse large B-cell lymphoma (DLBCL), is associated with a very poor outcome, especially when clonally related to the pre-existing CLL, mechanisms leading to RS have not been clarified yet. To better understand the pathogenesis of RS, we analyzed a series of cases including: 59 RS, 28 CLL-phase of RS, 315 CLL and 127 de novo DLBCL. more...
    Organism:
    Homo sapiens
    Type:
    Genome variation profiling by SNP array; SNP genotyping by SNP array
    Platform:
    GPL6801
    146 Samples
    Download data:
    GEO (CEL, TXT)
    Series
    Accession:
    GSE50252
    ID:
    200050252
    9.

    Essential role of IRF4 and MYC signaling for survival of anaplastic large cell lymphoma survival

    (Submitter supplied) Three ALCL cell lines DEL, FEPD and K299 were induced with an IRF4-specific shRNA for up to 96 hours.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL10558
    24 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE59747
    ID:
    200059747
    10.

    Gene expression changes induced by the pan-PIM inhibitor ETP-39010 in 4 peripheral T cell lymphoma cell lines

    (Submitter supplied) Peripheral T cell lymphoma (PTCL) is a very aggressive disease which currently lacks efficient targeted therapy. New therapeutic strategies are needed to improve the very poor outcome of these patients. In these study we hypothesized that PIM kinases could be of therapeutic value in PTCL because we found an overexpression of PIM1 and PIM2, but not PIM3, in PTCL cases, cell lines and primary tumoral T cells from Sezary Syndrome patients, compared with reactive lymph nodes and normal T cells from healthy donors, respectively. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL6480
    48 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE42595
    ID:
    200042595
    11.

    Gene expression profiling of human peripheral T cell lymphoma cases vs. reactive lymph nodes

    (Submitter supplied) Peripheral T cell lymphoma (PTCL) is a very aggressive disease which currently lacks efficient targeted therapy. New therapeutic strategies are needed to improve the very poor outcome of these patients. However, little is known about the molecular pathogenesis of this disease. In this study, we performed a gene expression profiling analysis of a series of 38 PTCL cases in order to find deregulated pathways or genes that could become therapeutic agents for PTCL patients.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL6480
    44 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE36172
    ID:
    200036172

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