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    Results: 18

    1.
    Full record GDS1521

    Heat shock transcription factor 1 C-terminal domain mutant

    Expression profiling of heat shock factor 1 (HSF1) C-terminal domain mutant (hsf1-ba1). The hsf1-ba1 mutation inhibits the heat-induced hyperphosphorylation of Hsf1. Results identify genes whose transcriptional response to heat shock is reduced by the hsf1-ba1 mutation.
    Organism:
    Saccharomyces cerevisiae
    Type:
    Expression profiling by array, transformed count, 2 genotype/variation sets
    Platform:
    GPL205
    Series:
    GSE3361
    4 Samples
    Download data:
    GEO
    DataSet
    Accession:
    GDS1521
    ID:
    1521
    2.

    Yeast HSF1 vs hsf1-ba1

    (Submitter supplied) Upon heat shock, Hsf1 protein is extensively phosphorylated, however, this modification is inhibited by an hsf1-bal mutation. To get genome-wide effect of the hyperphosphorylation on Hsf1-regulated transcription, the heat-induced gene expression profiles in HSF1 and hsf1-bal cells were compared. Keywords: stress response
    Organism:
    Saccharomyces cerevisiae
    Type:
    Expression profiling by array
    Dataset:
    GDS1521
    Platform:
    GPL205
    4 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE3361
    ID:
    200003361
    3.

    yeast hsf1-R206S/F256S mutant

    (Submitter supplied) Effect of hsf1-R206S/F256S mutation on heat-induced transcription of genes is analyzed. Total RNA was isolated from HSF1 wild type and hsf1-R206S/F256S cells grown at 39oC for 15 min. Probe cDNA was primed by oligo(dT) and was synthesized in the presence of 33P-dCTP. Hybridization was carried out using the same GF100 GeneFilter. Value higher than 30 in HSF1 wild type cells is confident. Values from duplicate experiments were averaged, and the average fold changes were calculated. more...
    Organism:
    Saccharomyces cerevisiae
    Type:
    Expression profiling by array
    Dataset:
    GDS1073
    Platform:
    GPL205
    4 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE2103
    ID:
    200002103
    4.
    Full record GDS1073

    Heat shock transcription factor 1 mutant response to heat stress

    Analysis of a heat shock transcription factor 1 (HSF1) temperature sensitive mutant strain subjected to heat stress at 33 degrees C. HSF1 mutant contains an arginine to serine and a phenylalanine to serine substitution at residues 206 and 256 respectively. Results identify novel targets of HSF1.
    Organism:
    Saccharomyces cerevisiae
    Type:
    Expression profiling by array, transformed count, 2 genotype/variation sets
    Platform:
    GPL205
    Series:
    GSE2103
    4 Samples
    Download data:
    GEO
    DataSet
    Accession:
    GDS1073
    ID:
    1073
    5.

    Stress-dependent dynamics of chromatin remodeling in yeast: Dual roles for SWI/SNF in heat shock stress response

    (Submitter supplied) Total H4 and acetyl H4 IP, time course Total H4 and acetyl H4 occupancy, Snf2 occupancy, gene expression analysis Keywords: stress response, time course
    Organism:
    Saccharomyces cerevisiae
    Type:
    Genome binding/occupancy profiling by array; Expression profiling by array
    Platform:
    GPL5076
    167 Samples
    Download data:
    GEO (GPR)
    Series
    Accession:
    GSE7665
    ID:
    200007665
    6.

    Nutrient-Regulated Antisense and Intragenic RNAs Modulate a Signal Transduction Pathway

    (Submitter supplied) The budding yeast Saccharomyces cerevisiae alters its gene expression profile in response to a change in nutrient availability. The PHO-system is a well-studied case in the transcriptional regulation responding to nutritional changes in which a set of genes (PHO genes) is expressed to activate phosphate (Pi) metabolism for adaptation to Pi-starvation. Pi-starvation triggers an inhibition of Pho85 kinase, leading to migration of unphosphorylated Pho4 transcriptional activator into the nucleus enabling expression of PHO genes. more...
    Organism:
    Saccharomyces cerevisiae
    Type:
    Genome binding/occupancy profiling by genome tiling array
    Platform:
    GPL3723
    8 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE13350
    ID:
    200013350
    7.

    Rap1 and Abf1 DNA-binding ts mutants and wild type after 1 hr at 37 C

    (Submitter supplied) Abf1 and Rap1 are General Regulatory Factors that contribute to transcriptional activation of a large number of genes, as well as to replication, silencing, and telomere structure in yeast. In spite of their widespread roles in transcription, the scope of their functional targets genome-wide has not been previously determined. We have used microarrays to examine the contribution of these essential GRFs to transcription genome-wide, by using ts mutants that dissociate from their binding sites at 37 C. more...
    Organism:
    Saccharomyces cerevisiae
    Type:
    Expression profiling by array
    Datasets:
    GDS2533 GDS3198
    Platform:
    GPL90
    12 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE6073
    ID:
    200006073
    8.
    Full record GDS3198

    Abf1 DNA-binding mutant

    Analysis of temperature sensitive Abf1 mutant cells subjected to a temperature of 37 degrees C to dissociate the mutant protein from its DNA binding sites. Results provide insight into the contribution of this general regulatory factor to transcription genome-wide.
    Organism:
    Saccharomyces cerevisiae
    Type:
    Expression profiling by array, count, 2 genotype/variation sets
    Platform:
    GPL90
    Series:
    GSE6073
    6 Samples
    Download data:
    GEO (CEL)
    9.
    Full record GDS2533

    Rap1 DNA-binding mutant

    Analysis of temperature sensitive Rap1 mutant cells subjected to a temperature of 37 degrees C to dissociate the mutant protein from its DNA binding sites. Results provide insight into the contribution of this general regulatory factor to transcription genome-wide.
    Organism:
    Saccharomyces cerevisiae
    Type:
    Expression profiling by array, count, 2 genotype/variation sets
    Platform:
    GPL90
    Series:
    GSE6073
    6 Samples
    Download data:
    GEO (CEL)
    10.

    Global effects of spt10 mutations on gene expression in budding yeast.

    (Submitter supplied) Using yeast strains based on the protease-deficient strain BJ5459 (= wild type), the effects of the spt10-null and spt10-C388S mutations on global gene expression were assessed and compared. BJ5459 (wild type) and BJ-SPT10(C388S)-HA cells were grown in synthetic complete medium to A600 = 0.6. RNA was prepared using an RNeasy kit (Qiagen). Biotinylated cRNA was prepared from three independently prepared sample pairs and hybridised to Affymetrix S98 arrays and detected using fluorescently labelled streptavidin. more...
    Organism:
    Saccharomyces cerevisiae
    Type:
    Expression profiling by array
    Dataset:
    GDS1534
    Platform:
    GPL90
    9 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE3354
    ID:
    200003354
    11.

    Role of yeast Spt10p in gene expression

    (Submitter supplied) Comparison of gene expression patterns for wild type yeast (BJ5459) and spt10-null::URA3 cells. Triplicate samples. Keywords = yeast SPT10 Keywords: repeat sample
    Organism:
    Saccharomyces cerevisiae
    Type:
    Expression profiling by array
    Dataset:
    GDS1270
    Platform:
    GPL90
    6 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE2407
    ID:
    200002407
    12.
    Full record GDS1534

    DNA-binding protein SPT10 mutants

    Analysis of spt10 null deletion and spt10(C388S) mutants. SPT10 encodes a putative histone acetyltranferase implicated as a global transcription regulator and is involved in chromatin maintenance. The C388S mutation disrupts a predicted zinc finger that may be part of the DNA-binding domain.
    Organism:
    Saccharomyces cerevisiae
    Type:
    Expression profiling by array, count, 3 genotype/variation sets
    Platform:
    GPL90
    Series:
    GSE3354
    9 Samples
    Download data:
    GEO
    DataSet
    Accession:
    GDS1534
    ID:
    1534
    13.
    Full record GDS1270

    SPT10 global transcription regulator null mutant

    Expression profiling of mutants lacking Spt10p. Spt10p binds the upstream activating sequences in all major core histone promoters. Results provide insight into the mechanism by which Spt10p acts as a global regulator of transcription.
    Organism:
    Saccharomyces cerevisiae
    Type:
    Expression profiling by array, count, 2 genotype/variation sets
    Platform:
    GPL90
    Series:
    GSE2407
    6 Samples
    Download data:
    GEO
    14.

    Effect 14-3-3 mutation on mRNA levels in yeast.

    (Submitter supplied) Studies on the effect of a bmh2 mutation on the genome-wide steady-state mRNA levels in Saccharomyces cerevisiae. Keywords: other
    Organism:
    Saccharomyces cerevisiae
    Type:
    Expression profiling by array
    Platform:
    GPL583
    4 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE850
    ID:
    200000850
    15.

    Simultaneous activation of heat shock and oxidative stress pathways by celastrol

    (Submitter supplied) Stress response pathways allow cells to rapidly sense and respond to deleterious environmental changes, including those caused by pathophysiological disease states. A previous screen for small molecules capable of activating the human heat shock response identified the triterpenoid celastrol as a potent activator of the heat shock transcription factor HSF1. We show here that celastrol likewise activates the homologous Hsf1 of Saccharomyces cerevisiae. more...
    Organism:
    Saccharomyces cerevisiae
    Type:
    Expression profiling by array
    Dataset:
    GDS2343
    Platform:
    GPL4226
    4 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE5608
    ID:
    200005608
    16.
    Full record GDS2343

    Triterpenoid celastrol treatment and heat shock comparison

    Analysis of wild type cells treated with 10 uM of the triterpenoid celastrol for 1 hour or subjected to heat shock at 39 degrees C for 30 minutes. Celestrol is a small molecule that activates the human heat shock transcription factor HSF1.
    Organism:
    Saccharomyces cerevisiae
    Type:
    Expression profiling by array, log2 ratio, 2 agent sets
    Platform:
    GPL4226
    Series:
    GSE5608
    4 Samples
    Download data:
    GEO
    17.

    Tiling Array HSF immunopurification

    (Submitter supplied) Mapping of in vivo Heat Shock Factor binding sites in drosophila embryos with genomic tiling arrays Keywords: repeat sample
    Organism:
    Drosophila melanogaster
    Type:
    Genome binding/occupancy profiling by genome tiling array
    Platform:
    GPL1918
    10 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE2423
    ID:
    200002423
    18.

    Drosophila HSF chromatin IP -cDNA array

    (Submitter supplied) Chromatin immunopurifications from heat shocked drosophila embryos with anti-Heat shock factor sera compared with immunopurification with pre-immune sera. Hybridisations to cDNA arrays. Keywords: repeat sample
    Organism:
    Drosophila melanogaster
    Type:
    Genome binding/occupancy profiling by array
    Platform:
    GPL1898
    17 Samples
    Download data:
    GEO
    Series
    Accession:
    GSE2398
    ID:
    200002398

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