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    Results: 1 to 20 of 13903

    1.
    Full record GDS4506

    Liver response to obesity and fasting

    Analysis of liver endoplasmic reticulum (ER)-associated polysomes from leptin deficient (ob/ob) males after overnight fasting. The liver is critical for metabolic homeostasis. Results provide insight into molecular mechanisms underlying changes in protein metabolism caused by obesity and diabetes.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, count, 2 genotype/variation, 2 protocol sets
    Platform:
    GPL1261
    Series:
    GSE39375
    10 Samples
    Download data:
    GEO (CEL, CHP)
    2.
    Full record GDS4413

    Long-term pioglitazone effect on triple transgenic model of Alzheimer's disease (3xTg-AD): hippocampus

    Analysis of hippocampus from 10 month-old, triple-transgenic AD females treated with the thiazolidinedione pioglitazone (PIO) for 14 weeks. TZDs exert cognitive benefits early in the AD process. Results provide insight into molecular mechanisms underlying the neuroprotective role of PIO in AD.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, transformed count, 2 agent sets
    Platform:
    GPL1261
    Series:
    GSE32536
    16 Samples
    Download data:
    GEO (CEL)
    3.
    Full record GDS4412

    Dietary fatty acid composition effect on vastus lateralis muscle

    Analysis of skeletal muscle (SM) from insulin resistant men 4 hrs after consumption of meals high in saturated FA (SFA), monounsaturated FA (MUFA), or polyunsaturated FA (PUFA). Results provide insight into mechanisms underlying effects of FA composition on SM FA handling and insulin sensitivity.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 10 individual, 3 protocol, 2 time sets
    Platform:
    GPL6244
    Series:
    GSE31901
    56 Samples
    Download data:
    GEO (CEL)
    DataSet
    Accession:
    GDS4412
    ID:
    4412
    4.
    Full record GDS4399

    Polycystic ovary syndrome: granulosa cells

    Analysis of granulosa cells from ovarian aspirates from polycystic ovary syndrome (PCOS) women undergoing in vitro fertilization. PCOS is an endocrine disorder associated with greater risk for infertility, diabetes and cardiovascular diseases. Results provide insight into molecular basis of PCOS.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, count, 2 disease state sets
    Platform:
    GPL570
    Series:
    GSE34526
    10 Samples
    Download data:
    GEO (CEL)
    5.
    Full record GDS4354

    Endogenous Cushing's Syndrome bone biopsies: pre- and post-surgery

    Analysis of bone biopsies from Cushing’s syndrome (CS) patients, before and mean 3 months after surgical treatment. Excess GC-induced bone loss is a serious complication in patients with endogenous CS. Results provide insight molecular mechanisms by which excess GCs influence bone metabolism.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 2 specimen sets
    Platform:
    GPL570
    Series:
    GSE30159
    18 Samples
    Download data:
    GEO (CEL)
    DataSet
    Accession:
    GDS4354
    ID:
    4354
    6.
    Full record GDS4347

    Pancreatic CD45+ immune cells from NOD model of type 1 diabetes

    Analysis of pancreatic CD45+ cells from 10 week-old NOD females MRI-scanned to noninvasively visualize effects of pancreatic-islet inflammation. All NOD juveniles develop insulitis but vary highly in their progression to diabetes. Results provide insight into molecular basis of disease progression.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, count, 5 individual sets
    Platform:
    GPL6246
    Series:
    GSE35096
    5 Samples
    Download data:
    GEO (CEL)
    7.
    Full record GDS4340

    Non-obese diabetic (NOD) and disease-resistant NOD.NOR-Chr4 models: splenic B cells

    Analysis of anti-IgM-F(ab’)2 fragment-stimulated, splenic B cells from non-obese diabetic (NOD) or NR4 (NOD background with Chromosome 4, type 1 diabetes (T1D)-resistance alleles) females. Results provide insight into the molecular mechanisms underlying NOD and NR4 diabetogenic activity.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, transformed count, 2 agent, 2 strain sets
    Platform:
    GPL1261
    Series:
    GSE37294
    11 Samples
    Download data:
    GEO (CEL)
    8.
    Full record GDS4337

    Type 2 diabetic and hyperglycemic pancreatic islets

    Analysis of pancreatic islets from type 2 diabetes (T2D) and non-diabetic cadaver donors. Glycemic control (HbA1c) levels also measured from the same individuals (normoglycemic: HbA1c < 6%; hyperglycemic: HbA1c ≥ 6%). Results provided insight into molecular basis of islet dysfunction in T2D.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 2 disease state, 23 other sets
    Platform:
    GPL6244
    Series:
    GSE38642
    63 Samples
    Download data:
    GEO (CEL)
    DataSet
    Accession:
    GDS4337
    ID:
    4337
    9.
    Full record GDS4334

    B7x effect on CD8 T cell-mediated diabetes model AI4αβ: pancreatic CD8 T cells

    Analysis of pancreatic AI4αβ CD8 T cells isolated from Rip-B7xAI4αβ (overexpressing B7x in the β cells) and AI4αβ (lacking B7x) mice. B7x inhibits CD8 T cell-induced diabetes. Results provide insight into the molecular basis for abrogation of diabetes by B7x overexpression in β cells.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, transformed count, 2 disease state, 2 genotype/variation sets
    Platform:
    GPL6246
    Series:
    GSE40225
    6 Samples
    Download data:
    GEO (CEL)
    10.
    Full record GDS4331

    Raf kinase inhibitor 1 knockout effect on C57BL/6 pancreas

    Analysis of pancreas from Raf kinase inhibitor 1 (Rkip1) knockouts. Rkip1-/- mice exhibit a larger pancreas and increased beta cell mass and pancreatic insulin content. Results provide insight into the role of Rkip1 in regulation of pancreatic beta cell function and proliferation.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, transformed count, 2 genotype/variation sets
    Platform:
    GPL1261
    Series:
    GSE31150
    6 Samples
    Download data:
    GEO (CEL)
    DataSet
    Accession:
    GDS4331
    ID:
    4331
    11.
    Full record GDS4314

    Diabetic ischemic heart failure patients: non-infarcted left ventricle

    Analysis of left ventricle cardiac biopsies taken from the vital, non-infarcted zone of diabetic patients with ischemic heart failure (HF). Increased morbidity and mortality are associated with ischemic HF in diabetic patients. Results provide insight into the underlying pathogenetic mechanisms.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 3 disease state sets
    Platform:
    GPL6244
    Series:
    GSE26887
    24 Samples
    Download data:
    GEO (CEL)
    12.
    Full record GDS4296

    NCI-60 cancer cell line panel

    Analysis of cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, and Renal) from the NCI-60 panel. Results provide insight into molecular mechanisms underlying the various cancer types.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 59 cell line, 27 disease state, 9 tissue sets
    Platform:
    GPL570
    Series:
    GSE32474
    174 Samples
    Download data:
    GEO (CEL)
    13.
    Full record GDS4282

    Clear-cell renal cell carcinoma tumors and tumorgrafts deficient for tumor suppressor BAP1 or PBRM1

    Analysis of BAP1- and PBRM1-deficient ccRCC primary tumors, tumors growing in immunodeficient mice (tumorgrafts), and matched normal kidney cortices. BAP1 loss, but not PBRM1 loss, is associated with high-grade tumors. Results provide insight into molecular classification of RCC subtypes.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 3 genotype/variation, 29 individual, 11 tissue sets
    Platform:
    GPL570
    Series:
    GSE36895
    76 Samples
    Download data:
    GEO (CEL)
    14.
    Full record GDS4276

    Subcutaneous and visceral adipose tissue from lean or obese children

    Analysis of subcutaneous and visceral adipose tissue (VAT) from lean and obese pre-pubertal children. The inflammatory environment of VAT may promote insulin resistance and type 2 diabetes. Results provide insight into molecular mechanisms underlying the inflammatory milieu of VAT in children.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 2 disease state, 2 gender, 2 tissue sets
    Platform:
    GPL6244
    Series:
    GSE29718
    20 Samples
    Download data:
    GEO (CEL)
    DataSet
    Accession:
    GDS4276
    ID:
    4276
    15.
    Full record GDS4234

    Transgenic model Tg26 of HIV-Associated Nephropathy: kidney cortex

    Analysis of kidney cortices from HIV-1 transgenic, FVB/N males and females (Tg26). Tg26 models the renal pathologic changes observed in human disease and is used to study HIV-associated nephropathy (HIVAN) pathogenesis. Results provide insight into the molecular mechanisms underlying HIVAN.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, transformed count, 2 genotype/variation sets
    Platform:
    GPL1261
    Series:
    GSE35226
    12 Samples
    Download data:
    GEO (CEL, CHP)
    16.
    Full record GDS4233

    Protein kinase HIPK2 overexpression effect on Human Embryonic Kidney cells

    Analysis of HEK293 cells transfected with homeo-domain interacting protein kinase 2 (HIPK2) and HIPK2-DN mutant. HIPK2 mediates renal fibrosis in 3 mouse models of renal fibrosis (Tg26, UUO, folic-acidinduced renal fibrosis). Results provide further insight into role of HIPK2 in kidney fibrosis.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 3 genotype/variation sets
    Platform:
    GPL6244
    Series:
    GSE35226
    12 Samples
    Download data:
    GEO (CEL, CHP)
    17.
    Full record GDS4228

    HIV infection and Antiretroviral Therapy effects on mitochondria in various tissues

    Analysis of PBMCs, muscle, adipose tissue from human immunodeficiency virus (HIV)-positive adults receiving nucleoside reverse transcriptase inhibitor (NRTI)-based ART. Results provide insight into molecular mechanisms underlying the divergent effects of HIV infection and ART on mitochondria in fat.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, transformed count, 3 agent, 2 disease state, 3 tissue sets
    Platform:
    GPL9392
    Series:
    GSE30310
    166 Samples
    Download data:
    GEO (CEL)
    18.
    Full record GDS4220

    HIV-associated nephropathy model: kidney

    Analysis of kidney from TgFVB transgenic mouse model of Human Immunodeficiency Virus-Associated Nephropathy (HIVAN). HIVAN is characterized by rapid progressive kidney dysfunction and prominent tubular damage. Results provide insight into molecular mechanism underlying HIVAN-related tubular disease.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, count, 2 disease state, 2 strain, 2 time sets
    Platform:
    GPL1261
    Series:
    GSE14221
    4 Samples
    Download data:
    GEO (CEL, CHP)
    19.
    Full record GDS4164

    Compendium of normal tissues

    Analysis of 10 pathologically normal tissues (liver, kidney, heart, lung, brain, lymph node, spleen, jejunum, pancreas, and skeletal muscle) from each of four dogs. Results provide insight into normal tissue expression to facilitate disease study and comparative genomic analysis with other mammals.
    Organism:
    Canis lupus familiaris
    Type:
    Expression profiling by array, transformed count, 10 tissue sets
    Platform:
    GPL3738
    Series:
    GSE20113
    39 Samples
    Download data:
    GEO (CEL)
    20.
    Full record GDS4133

    Obese women with polycystic ovary syndrome and obese, healthy women: skeletal muscle

    Analysis of skeletal muscle from obese women with polycystic ovary syndrome (PCOS) and obese, healthy women. Results provide insight into whether pioglitazone ameliorates preexisting abnormalities in PCOS patients.
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array, count, 2 disease state sets
    Platform:
    GPL570
    Series:
    GSE8157
    23 Samples
    Download data:
    GEO (CEL)

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      Supplemental Content

      db=gds|term=kidney%20disease|query=1|qty=46|blobid=NCID_1_184654803_130.14.22.215_9001_1409289189_2110474358_0MetA0_S_MegaStore_F_1|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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