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    Results: 1 to 20 of 21

    1.
    Full record GDS4316

    Heart, kidney and lung during juvenile growth

    Analysis of heart, kidney, and lung from C57BL/6 males at 1, 4, 8 weeks of age. Mammalian somatic growth is rapid in early postnatal life but slows and eventually ceases in multiple tissues. Results provide insight into molecular events common to multiple tissues that regulate growth deceleration.
    Organism:
    Mus musculus
    Type:
    Expression profiling by array, count, 3 time, 3 tissue sets
    Platform:
    GPL1261
    Series:
    GSE38754
    40 Samples
    Download data:
    GEO (CEL)
    2.

    PW1/Peg3 expression regulates the key properties that determine mesoangioblast stem cell competence

    (Submitter supplied) Mesoangioblasts are vessel-associated progenitor cells that show therapeutic promise for the treatment of muscular dystrophy. Mesoangioblasts have the ability to undergo skeletal muscle differentiation and cross the blood vessel wall regardless of the developmental stage at which they are isolated. Here we show that PW1/Peg3 is expressed at high levels in mesoangioblasts obtained from mouse, dog and human tissues and its level of expression correlates with their myogenic competence. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL6246
    4 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE64334
    ID:
    200064334
    3.

    microRNA profiling of normal testes and testicular germ cell tumors using deep sequencing approach

    (Submitter supplied) Several observations have pointed a link between small RNA pathway and testicular germ cell tumorigenesis. Yet, the role of small RNAs in testicular germ cell tumors (TGCTs) is still not completely understood. In this study, we characterized the expression profiles of sRNAs in 9 primary sporadic TGCTs and 2 normal testes (NTs) using a sequencing approach. Our data show comprehensive coverage of microRNAs (miRNAs) expressed in human TGCT tissues and NTs, including the identification of 29 candidate novel miRNAs. more...
    Organism:
    Homo sapiens
    Type:
    Non-coding RNA profiling by high throughput sequencing
    Platform:
    GPL9052
    11 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE59267
    ID:
    200059267
    4.

    Peg3 mutational effects on reproduction and placenta-specific gene families

    (Submitter supplied) Peg3 (paternally expressed gene 3) is an imprinted gene encoding a DNA-binding protein. This gene plays important roles in controlling fetal growth rates and nurturing behaviors. In the current study, a new mutant mouse model has been generated to further characterize the functions of this DNA-binding protein. Besides known phenotypes, this new mutant model also revealed potential roles of Peg3 in mammalian reproduction. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL6885
    16 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE50818
    ID:
    200050818
    5.

    Role of Tet1 in genomic imprinting erasure [RRBS-sperm]

    (Submitter supplied) Genomic imprinting is an allele-specific gene expression system important for mammalian development and function. The molecular basis of genomic imprinting is allele-specific DNA methylation 2. While it is well known that the de novo DNA methyltransferases Dnmt3a/b are responsible for the establishment of genomic imprinting, how the methylation mark is erased during primordial germ cell (PGC) reprogramming remains a mystery. more...
    Organism:
    Mus musculus
    Type:
    Methylation profiling by high throughput sequencing
    Platform:
    GPL17021
    8 Samples
    Download data:
    GEO (BEDGRAPH), SRA SRP028715
    Series
    Accession:
    GSE49763
    ID:
    200049763
    6.

    Role of Tet1 in genomic imprinting erasure [RRBS-PGC]

    (Submitter supplied) Genomic imprinting is an allele-specific gene expression system important for mammalian development and function. The molecular basis of genomic imprinting is allele-specific DNA methylation 2. While it is well known that the de novo DNA methyltransferases Dnmt3a/b are responsible for the establishment of genomic imprinting, how the methylation mark is erased during primordial germ cell (PGC) reprogramming remains a mystery. more...
    Organism:
    Mus musculus
    Type:
    Methylation profiling by high throughput sequencing
    Platform:
    GPL17021
    4 Samples
    Download data:
    GEO (BEDGRAPH), SRA SRP028714
    Series
    Accession:
    GSE49762
    ID:
    200049762
    7.

    Role of Tet1 in genomic imprinting erasure [RNA-seq]

    (Submitter supplied) Genomic imprinting is an allele-specific gene expression system important for mammalian development and function. The molecular basis of genomic imprinting is allele-specific DNA methylation 2. While it is well known that the de novo DNA methyltransferases Dnmt3a/b are responsible for the establishment of genomic imprinting, how the methylation mark is erased during primordial germ cell (PGC) reprogramming remains a mystery. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL17021
    13 Samples
    Download data:
    GEO (TXT), SRA SRP028713
    Series
    Accession:
    GSE49761
    ID:
    200049761
    8.

    Characterization of the Imprinting Signature of Mouse Embryo Fibroblasts by RNA Deep Sequencing

    (Submitter supplied) Mouse embryo fibroblasts (MEFs) closely resemble mouse embryos and are convenient sources for biochemical studies when cell number may be limiting from mouse embryos. To derive the imprinting signature of MEFs and potentially detect novel imprinted genes we characterized them using strand- and allele-specific RNA deep sequencing. We used Sequenom allelotyping in embryo and adult organs to verify parental allele-specific expression patterns. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by high throughput sequencing
    Platform:
    GPL17021
    2 Samples
    Download data:
    GEO (GFF), SRA SRP028516
    Series
    Accession:
    GSE49538
    ID:
    200049538
    9.

    Comparing gene expression between PICs and satellite cells from 1 week old muscle

    (Submitter supplied) The satellite cell is considered the major tissue-resident stem cell underlying muscle regeneration, however, multiple non-satellite cell myogenic progenitors have been identified. PW1/Peg3 is expressed in satellite cells as well as a subset of interstitial cells with myogenic potential termed PICs (PW1+ Interstitial Cells). PICs differ from satellite cells by their anatomical location (satellite cells are sublaminal and PICs are interstitial), they do not express any myogenic marker and arise from a Pax3-independent lineage. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Platform:
    GPL1261
    6 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE40523
    ID:
    200040523
    10.

    Temporal changes of gene expression in mouse heart, kidney and lung during juvenile growth

    (Submitter supplied) Temporal changes of gene expression from 1-wk- to 4-wk and 8-wk-old mouse in heart, kidney and lung. Mammalian somatic growth is rapid in early postnatal life but then slows and eventually ceases in multiple tissues. We hypothesized that there exists a postnatal gene expression program that is common to multiple tissues and is responsible for this coordinate growth deceleration. Consistent with this hypothesis, microarray analysis identified >1600 genes that were regulated with age coordinately in kidney, lung, and heart of juvenile mice, including many genes that regulate proliferation. more...
    Organism:
    Mus musculus
    Type:
    Expression profiling by array
    Dataset:
    GDS4316
    Platform:
    GPL1261
    40 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE38754
    ID:
    200038754
    11.

    Differential gene profile of resorbed embryos following paternal tamoxifen treatment

    (Submitter supplied) Studies from our laboratory have demonstrated that treatment of adult male rats with tamoxifen, a selective estrogen receptor modulator, at a dose of 0.4 mg/kg/day for 60 days resulted in an increase in post-implantation loss at around mid gestation. The present study was done to assess global gene expression profile using Agilent Rat Whole Genome Microarray slides. Differential gene expression profile of resorbed to normal embryos at embryonic day (E) 11 and 13 was studied to identify the causes of resorption. more...
    Organism:
    Rattus norvegicus
    Type:
    Expression profiling by array
    Platform:
    GPL7294
    6 Samples
    Download data:
    GEO (TXT)
    Series
    Accession:
    GSE16137
    ID:
    200016137
    12.

    Head_knockout_male_replicate3

    Organism:
    Mus musculus
    Source name:
    Head_knockout_male
    Platform:
    GPL6885
    Series:
    GSE50818
    Download data:
    GEO
    Sample
    Accession:
    GSM1230339
    ID:
    301230339
    13.

    Head_knockout_female_replicate2

    Organism:
    Mus musculus
    Source name:
    Head_knockout_female
    Platform:
    GPL6885
    Series:
    GSE50818
    Download data:
    GEO
    Sample
    Accession:
    GSM1230338
    ID:
    301230338
    14.

    Head_knockout_male_replicate2

    Organism:
    Mus musculus
    Source name:
    Head_knockout_male
    Platform:
    GPL6885
    Series:
    GSE50818
    Download data:
    GEO
    Sample
    Accession:
    GSM1230336
    ID:
    301230336
    15.

    Head_knockout_female_replicate1

    Organism:
    Mus musculus
    Source name:
    Head_knockout_female
    Platform:
    GPL6885
    Series:
    GSE50818
    Download data:
    GEO
    Sample
    Accession:
    GSM1230335
    ID:
    301230335
    16.

    Head_knockout_male_replicate1

    Organism:
    Mus musculus
    Source name:
    Head_knockout_male
    Platform:
    GPL6885
    Series:
    GSE50818
    Download data:
    GEO
    Sample
    Accession:
    GSM1230334
    ID:
    301230334
    17.

    Placenta_knockout_male_replicate3

    Organism:
    Mus musculus
    Source name:
    Placenta_knockout_male
    Platform:
    GPL6885
    Series:
    GSE50818
    Download data:
    GEO
    Sample
    Accession:
    GSM1230331
    ID:
    301230331
    18.

    Placenta_knockout_female_replicate2

    Organism:
    Mus musculus
    Source name:
    Placenta_knockout_female
    Platform:
    GPL6885
    Series:
    GSE50818
    Download data:
    GEO
    Sample
    Accession:
    GSM1230330
    ID:
    301230330
    19.

    Placenta_knockout_male_replicate2

    Organism:
    Mus musculus
    Source name:
    Placenta_knockout_male
    Platform:
    GPL6885
    Series:
    GSE50818
    Download data:
    GEO
    Sample
    Accession:
    GSM1230328
    ID:
    301230328
    20.

    Placenta_knockout_female_replicate1

    Organism:
    Mus musculus
    Source name:
    Placenta_knockout_female
    Platform:
    GPL6885
    Series:
    GSE50818
    Download data:
    GEO
    Sample
    Accession:
    GSM1230327
    ID:
    301230327

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