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    Sample Matching by Inferred Agonal Stress in Gene Expression Analyses of the Brain

    (Submitter supplied) Gene expression patterns in the brain are strongly influenced by the severity of physiological stress at death. This agonal effect, if not well controlled, can lead to spurious findings in case-control comparisons. While many recent studies match samples by tissue pH and clinically recorded agonal conditions, we found that these commonly used indicators were sometimes at odds with observed stress-related patterns of gene expression, and that matching by these criteria still sometimes results in identifying differences between cases and controls that are primarily driven by residual agonal effects. more...
    Organism:
    Homo sapiens
    Type:
    Expression profiling by array
    Platform:
    GPL4557
    1218 Samples
    Download data:
    GEO (CEL)
    Series
    Accession:
    GSE6306
    ID:
    200006306

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