"disease state"[All Fields] AND "Homo Sapiens"[porgn] AND ("Sickle Cel - GEO DataSets

Select item 2001685321.

RNA-Seq analysis of classical monocyte in pateints with sickle cell disease [RNA-Seq]

(Submitter supplied) Patients with sickle cell disease (SCD) suffer from intravascular hemolysis associated vascular injury and tissue damage. Classical monocytes (CMo), which comprise most blood circulating monocytes. are activated in SCD, but the cause and consequences of activation is less clear. Using transcriptome analysis, we found upregulation of the type I Interferon (IFN) pathway in sort-purified SCD CMo.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23227
19 Samples

Download data: TXT

Series

Accession:: GSE168532

ID:: 200168532

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001028812.

Transcriptomic analysis of healthy donor and Sickle Cell Disease (SCD) hematopoietic stem/progenitor cells

(Submitter supplied) Human hematopoietic stem/progenitor cells (HSPCs) were either collected from bone marrow or mobilized from healthy donors and SCD patients. We performed RNA-seq analysis on RNA extracted from purified CD34+ HSPCs coming from the different sources to compare their gene expression profiles.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: TXT

Series

Accession:: GSE102881

ID:: 200102881

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000415753.

Role of platelet micrornas in sickle cell disease

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL10850 GPL14550
53 Samples

Download data: TXT

Series

Accession:: GSE41575

ID:: 200041575

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000115244.

The platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease

(Submitter supplied) In sickle cell disease, ischemia-reperfusion injury and intravascular hemolysis produce endothelial dysfunction and vasculopathy characterized by reduced nitric oxide (NO) and arginine bioavailability. Recent functional studies of platelets in patients with sickle cell disease reveal a basally activated state, suggesting that pathological platelet activation may contribute to sickle cell disease vasculopathy. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3318
Platform:: GPL570
30 Samples

Download data: CEL

Series

Accession:: GSE11524

ID:: 200011524

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 33185.

Sickle cell disease: platelets

Analysis of platelets from patients with sickle cell disease. Sickle cell disease patients exhibit increased activation of platelets. Results provide insight into the molecular basis of platelet dysfunction in sickle cell disease.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 disease state sets

Platform:: GPL570
Series:: GSE11524
30 Samples

Download data: CEL

DataSet

Accession:: GDS3318

ID:: 3318

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000018496.

Differential Gene Expression in Pulmonary Artery Endothelial Cells Exposed to Sickle Cell Plasma

(Submitter supplied) Clinical variability in sickle cell disease (SCD) suggests a role for extra-erythrocytic factors in the pathogenesis of vasoocclusion. We hypothesized that one potential factor, endothelial dysfunction, results from induction of phenotypic changes by circulating factors in SCD patients. The database reports gene expression in cultured human pulmonary artery endothelial cells (HPAEC) exposed to plasma from: a) sickle acute chest syndrome (ACS) patients (samples ; b) SCD patients at steady-state and c) normal volunteers using microarrays (U133A-B GeneChip Affymetrix). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Datasets:: GDS1257 GDS1258
Platforms:: GPL97 GPL96
65 Samples

Download data

Series

Accession:: GSE1849

ID:: 200001849

Select item 12587.

Sickle cell plasma effect on pulmonary artery endothelial cells (HG-U133B)

Expression profiling of pulmonary artery endothelial cells exposed to plasma from sickle cell disease (SCD) patients with sickle acute chest syndrome or from SCD patients at steady state. Results provide insight into the role of extra-erythrocytic factors in sickle cell vasoocclusion.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 disease state sets

Platform:: GPL97
Series:: GSE1849
32 Samples

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DataSet

Accession:: GDS1258

ID:: 1258

Select item 12578.

Sickle cell plasma effect on pulmonary artery endothelial cells (HG-U133A)

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 disease state sets

Platform:: GPL96
Series:: GSE1849
33 Samples

Download data

DataSet

Accession:: GDS1257

ID:: 1257

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