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1.

Bone Marrow Interstitial Light-chain Amyloid and its Microenvironment

(Submitter supplied) Amyloid deposition and neighboring tissue responses remain poorly understood. Twenty percent of patients with systemic light-chain amyloidosis (AL) have interstitial marrow amyloid containing clonal Ig light-chain fibrils and apolipoprotein chaperone proteins. We compared CD138-depleted aspirate mononuclear cells (MNC) from marrows of AL patients with (+MA) and without (-MA) interstitial amyloid by gene expression profiling (GEP) and single-cell RNA-sequencing (scRNA seq). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21697
8 Samples
Download data: TXT
Series
Accession:
GSE239717
ID:
200239717

2.

AMYLOIDOGENIC LIGHT CHAINS IMPAIR PLASMA CELL SURVIVAL

(Submitter supplied) We used lentiviral vectors to generate cell lines expressing LCs from patients suffering from AL amyloidosis.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
6 Samples
Download data: XLS
Series
Accession:
GSE176119
ID:
200176119

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db=gds|term=%22disease%20state%22[All%20Fields]%20AND%20%22Homo%20Sapiens%22[porgn]%20AND%20(%22Al%20Amyloidosis%22[MeSH%20Terms]%20OR%20%22Al%20Amyloidosis%22[All%20Fields])%20AND%20(%22gds%22[Filter]%20OR%20%22gse%22[Filter]%20OR%20%22gsm%22[Filter])%20AND%20(%22Expression%20profiling%20by%20array%22[Filter]%20OR%20Expression%20profiling%20by%20high%20throughput%20sequencing[Filter])|query=1|qty=2|blobid=MCID_66230e28e53bb618e1708ae3|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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  • "disease state"[All Fields] AND "Homo Sapiens"[porgn] AND ("Al Am... (2)
    "disease state"[All Fields] AND "Homo Sapiens"[porgn] AND ("Al Amyloidosis"[MeSH Terms] OR "Al Amyloidosis"[All Fields]) AND ("gds"[Filter] OR "gse"[Filter] OR "gsm"[Filter]) AND ("Expression profiling by array"[Filter] OR Expression profiling by high throughput sequencing[Filter])
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