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Results: 1 to 20 of 67

1.
Full record GDS4850

Acute cold exposure effect on brown adipose tissue

Analysis of brown adipose tissue from C57BL/6J animals exposed to 4 degrees C for 4 hours. Results compared to those obtained from skeletal muscles (GDS4849) in order to gain insight into the molecular processes influencing energy expenditure.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 temperature sets
Platform:
GPL6103
Series:
GSE40486
4 Samples
Download data:
GEO
2.
Full record GDS4849

Acute cold exposure effect on skeletal muscle

Analysis of quadriceps muscles from C57BL/6J animals exposed to 4 degrees C for 4 hours. Results compared to those obtained from brown adipose tissues (GDS4850) in order to gain insight into the molecular processes influencing energy expenditure.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 temperature sets
Platform:
GPL6103
Series:
GSE40486
4 Samples
Download data:
GEO
3.

De novo Reconstruction of Adipose Tissue Transcriptomes Reveals Novel Long Non-coding RNAs that Regulate Brown Adipocyte Development

(Submitter supplied) Brown adipose tissue (BAT) protects against obesity by promoting energy expenditure via uncoupled respiration. To uncover BAT-specific long non-coding RNAs (lncRNAs), we used RNA-seq to reconstruct de novo transcriptomes of mouse brown, inguinal white, and epididymal white fat and identified ~1500 lncRNAs, including 127 BAT-restricted loci induced during differentiation and often targeted by key regulators PPARγ, C/EBPα and C/EBPβ. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
8 Samples
Download data:
GEO (BW), SRA SRP055995
Series
Accession:
GSE66686
ID:
200066686
4.

IGF2BP2/IMP2 Deficient Mice Resist Obesity through enhanced translation of Ucp1 mRNA and other mRNAs encoding Mitochondrial Proteins

(Submitter supplied) Imp2 -/- mice were subjected to a number of characterization assays, including RNA-Seq of various tissues,
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Other
Platform:
GPL11002
26 Samples
Download data:
GEO (FPKM_TRACKING, TXT), SRA SRP055722
Series
Accession:
GSE66440
ID:
200066440
5.

Cistromic and epigenomic changes in Prdm16 knock-out brown adipose tissue

(Submitter supplied) Prdm16 is a transcription factor that drives a complete program of brown adipocyte differentiation, but the mechanism by which Prdm16 activates gene transcription remains unknown. Utilizing ChIP-seq teqhnique, we found that Prdm16 binds to chromatin at/near many brown fat-selective genes in BAT. Interestingly, Prdm16-deficiency dramatically reduced the binding of Med1 to Prdm16-target sites. Indeed, Prdm16 binds and recruits Med1 to BAT-enriched genes and the loss of Prdm16 caused a fundamental change in chromatin architecture at key BAT-selective genes and also reduced transcirptional activity. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL11002 GPL13112
11 Samples
Download data:
GEO (BW), SRA SRP050953
Series
Accession:
GSE63965
ID:
200063965
6.

Temporal gene expression profiling of Multiple murine tissues with different diet regimens

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL19146
688 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE63178
ID:
200063178
7.

Temporal gene expression profiling of murine brown infiltrating macrophages (SVCs) with different diet regimens [brown SVCs]

(Submitter supplied) In the present study, we used C57BL/6J mouse, as a model for studying diet-induced diabetes and obesity, since this strain accumulates adipose tissue mass, insulin resistance, hyper-insulinemia, and hyper-lipidemia similar to humans fed on an high-fat high-sugar diet (HFHSD).
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL19146
39 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE63169
ID:
200063169
8.

Temporal gene expression profiling of murine brown adipose with different diet regimens [brown adipose]

(Submitter supplied) In the present study, we used C57BL/6J mouse, as a model for studying diet-induced diabetes and obesity, since this strain accumulates adipose tissue mass, insulin resistance, hyper-insulinemia, and hyper-lipidemia similar to humans fed on an high-fat high-sugar diet (HFHSD).
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL19146
38 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE63168
ID:
200063168
9.

Large numbers of putative miRNAs originate from DNA transposons and are coincident with a large species radiation in bats.

(Submitter supplied) Vesper bats (family Vespertilionidae) experienced a rapid adaptive radiation beginning around 36 mya that resulted in the second most species rich mammalian family. Coincident with that radiation was an initial burst of DNA transposon activity that has continued into the present. Deep sequencing of small RNAs from the vespertilionid, Eptesicus fuscus, as well as dog and horse revealed that substantial numbers of novel bat miRNAs are derived from DNA transposons unique to vespertilionids. more...
Organism:
Eptesicus fuscus; Canis lupus familiaris; Equus caballus
Type:
Non-coding RNA profiling by high throughput sequencing
Platforms:
GPL15545 GPL17229 GPL16540
4 Samples
Download data:
GEO (TXT), SRA SRP023527
Series
Accession:
GSE47593
ID:
200047593
10.

EBF2 determines and maintains brown adipocyte identity

(Submitter supplied) We compared PPARg binding sites in BAT and eWAT to identify regulatory elements that contribute to BAT identity and to find an important factor that bind those elements. To this end, we performed PPARg ChIP-seq in both tissues and called each tissue-spsecific binding sites.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL11002 GPL13112
2 Samples
Download data:
GEO (BED), SRA SRP018214
Series
Accession:
GSE43763
ID:
200043763
11.

Zbtb16 Has a Role in Brown Adipocyte Bioenergetics

(Submitter supplied) Study designed to identify genes that are induced in both BAT and skeletal muscle during acute adaptive thermogenesis in mouse using gene expression microarray. Animal studies were performed under approved UCLA animal research protocols and according to guidelines established in the Guide for Care and Use of Laboratory Animals. C57BL/6J mice were maintained in 12-h light/dark conditions and fed a regular chow diet (Purina 50010, Lab Diet, USA). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS4849 GDS4850
Platform:
GPL6103
8 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE40486
ID:
200040486
12.

Biological Aging and Circadian Mechanisms in Murine Brown Adipose Tissue, Inguinal White Adipose Tissue, and Liver (Jan 2010 dataset)

(Submitter supplied) The circadian profile of the transcriptomes in murine tissues was compared between groups of young and old male mice. The oscillatory phase and absolute expression levels were evaluated as a function of biological age. Distinct differences in multiple pathways were apparent based on biological and circadian time in a tissue specific manner.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
36 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE25324
ID:
200025324
13.

Biological Aging and Circadian Mechanisms in Murine Brown Adipose Tissue, Inguinal White Adipose Tissue, and Liver (Nov 2009 dataset)

(Submitter supplied) The circadian profile of the transcriptomes in murine tissues was compared between groups of young and old male mice. The oscillatory phase and absolute expression levels were evaluated as a function of biological age. Distinct differences in multiple pathways were apparent based on biological and circadian time in a tissue specific manner.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
36 Samples
Download data:
GEO (TXT)
Series
Accession:
GSE25323
ID:
200025323
14.

Alternative splicing of the TRPV1 gene underlies infrared sensation in vampire bats

(Submitter supplied) Vampire bats and snakes have taken thermosensation to the extreme by developing specialized systems for detecting infrared radiation. As such, these creatures provide a window into the molecular and genetic mechanisms underlying evolutionary tuning of thermoreceptors in a species or cell type specific manner. In each case, robust thermal sensitivity likely reflects specialized anatomical features of infrared sensing pit organs, as well as intrinsic heat sensitivity of trigeminal nerve fibers that innervate these structures. more...
Organism:
Desmodus rotundus; Carollia brevicauda
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL13344 GPL13343
4 Samples
Download data:
GEO (TXT), SRA SRP007670
Series
Accession:
GSE28243
ID:
200028243
15.

Expression data from white and brown adipose tissue (WAT and BAT) of per2-/- and control mice

(Submitter supplied) We found that the circadian protein PER2 interacts with the nuclear receptor PPARgamma to repress its activity. PPARgamma is a master regulator of adipogenesis and lipid metabolism and is very abundant in adipose tissue. We used microarrays to detail the global program of gene expression in adipose tissue lacking the per2 gene. This analysis identified several PPARgamma target genes up-regulated in adipose tissue from per2-/- mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
12 Samples
Download data:
GEO (CEL, TXT)
Series
Accession:
GSE20165
ID:
200020165
16.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...
Organism:
Mus musculus
517 DataSets
3431 Series
36 Related Platforms
44888 Samples
Download data:
GEO
Platform
Accession:
GPL1261
ID:
100001261
17.

[Rat230_2] Affymetrix Rat Genome 230 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 Protocol: see manufacturer's web site The GeneChip Rat Genome 230 2.0 Array is a powerful tool for toxicology, neurobiology, and other applications using rat as a model organism. more...
Organism:
Rattus norvegicus
96 DataSets
562 Series
12 Related Platforms
17803 Samples
Download data:
GEO
Platform
Accession:
GPL1355
ID:
100001355
18.

BAT_d5_siRNA

Organism:
Mus musculus
Source name:
brown adipocyte_siRNA
Platform:
GPL13112
Series:
GSE66686
Download data:
GEO (BW), SRA SRX913716
Sample
Accession:
GSM1627970
ID:
301627970
19.

BAT_d3_siRNA

Organism:
Mus musculus
Source name:
brown adipocyte_siRNA
Platform:
GPL13112
Series:
GSE66686
Download data:
GEO (BW), SRA SRX913715
Sample
Accession:
GSM1627969
ID:
301627969
20.

BAT_d5_NC

Organism:
Mus musculus
Source name:
brown adipocyte_NC
Platform:
GPL13112
Series:
GSE66686
Download data:
GEO (BW), SRA SRX913714
Sample
Accession:
GSM1627968
ID:
301627968

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    db=gds|term=%22Myliobatis%20californica%22%20or%20%22Bat%20Rays%22|query=1|qty=7|blobid=NCID_1_11011549_130.14.18.34_9001_1441077732_1693785815_0MetA0_S_MegaStore_F_1|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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