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Orphan CpG Islands Identify Numerous Conserved Promoters in the Mammalian Genome

ESS000073 - Study

Summary

In this study, single molecule-based sequencing technology in combination with CXXC affinity purifcation (CAP-seq), MBD affinity purification, and chromatin immunoprecipitation are used to generate reciprocal methylation and chromatin modifcation maps in human and mouse.

Keywords: transcription machinery, histone modification, DNA methylation, ChIP-seq, CAP-seq

Samples

Human sperm, individual pooled donors ages 24, 26, and 61

ESM000572 - Similar

Human, blood, individual pooled donors ages 24, 26, and 61

ESM000573 - Similar

Human, cerebellum, individual pooled donors ages 41, 50, and 54

ESM000574 - Similar

Mouse sperm, adult

ESM000575 - Similar

Mouse, blood, adult

ESM000576 - Similar

Mouse, cerebellum, adult

ESM000577 - Similar

Human embryonic stem cell, Shef 4 cell line, undifferentiated

ESM000593 - Similar

Mouse embryonic stem cell, E14Tg2A cell line, undifferentiated

ESM000594 - Similar

Total: 8 samples - View details

Experiments

Total: 12 experiments - View detailsDownload tracksView on genome

Data submission

Comprehensive analysis of orphan CpG islands identifes novel promoters with conserved DNA methylation dynamics

We report the application of single molecule-based sequencing technology in combination with CXXC affinity purifcation (CAP-seq), MBD affinity purification (MAP-seq) and chromatin immunoprecipitation (ChIP-seq) to generate reciprocal methylation and chromatin modifcation maps in human and mouse. We...

The University of Edinburgh. Public on: Oct 05 2010

GSE21442 - GEO

Reference

Orphan CpG islands identify numerous conserved promoters in the mammalian genome.

Illingworth RS, et al. PLoS Genet. 2010 Sep 23;6(9):e1001134. - Similar

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