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Regulation of microRNA Expression and Abundance during Lymphopoiesis

ESS000066 - Study

Summary

This study uses high throughput sequencing to characterize the microRNome from most developing lymphocyte cell types, various hematopoietic cell lineages, and representative mouse tissues.

Keywords: expression, smRNA-seq

Samples

Mouse pre-B cell, bone marrow, adult

ESM000474 - Similar

Mouse immature B cell, spleen, adult

ESM000475 - Similar

Mouse B lymphocyte, spleen, adult

ESM000476 - Similar

Mouse B lymphocyte, spleen, adult, activated (72 hr.)

ESM000477 - Similar

Mouse B lymphocyte, spleen, adult, activated (72 hr.)

ESM000478 - Similar

Mouse B lymphocyte, spleen, adult, activated (72 hr.)

ESM000479 - Similar

Mouse B lymphocyte, adult

ESM000480 - Similar

Mouse B lymphocyte, spleen marginal zone, adult

ESM000481 - Similar

Mouse B lymphocyte, lymph node germinal center, adult

ESM000482 - Similar

Mouse plasma cell, lymph node, adult

ESM000483 - Similar

Mouse hematopoietic progenitor cell, bone marrow, adult

ESM000484 - Similar

Mouse mast cell, bone marrow, adult

ESM000485 - Similar

Mouse basophil, bone marrow, adult

ESM000486 - Similar

Mouse neutrophil, adult

ESM000487 - Similar

Mouse dendritic cell, bone marrow, adult

ESM000488 - Similar

Mouse macrophage, bone marrow, adult

ESM000489 - Similar

Mouse natural killer cell, spleen

ESM000490 - Similar

Mouse T lymphocyte, thymus, adult

ESM000491 - Similar

Mouse T lymphocyte, spleen, adult, naïve

ESM000492 - Similar

Mouse T lymphocyte, spleen, adult

ESM000493 - Similar

Mouse T lymphocyte, spleen, adult, activated (120 hr.)

ESM000494 - Similar

Mouse T lymphocyte, spleen, adult, T helper (Th1)

ESM000495 - Similar

Mouse T lymphocyte, spleen, adult, T helper (Th2)

ESM000496 - Similar

Mouse T lymphocyte, spleen, adult, T helper (Th17)

ESM000497 - Similar

Mouse T lymphocyte, spleen, adult, T folicular helper

ESM000498 - Similar

Mouse T lymphocyte, spleen, adult, T regulatory (iTreg)

ESM000499 - Similar

Mouse T lymphocyte, spleen, adult, T regulatory (nTreg)

ESM000500 - Similar

Mouse embryonic stem cell, V6.5 cell line, undifferentiated

ESM000501 - Similar

Mouse fibroblast, embryo, passage 2

ESM000502 - Similar

Mouse, heart, adult

ESM000503 - Similar

Mouse, whole brain, adult

ESM000504 - Similar

Mouse, lung, adult

ESM000505 - Similar

Mouse, kidney, adult

ESM000507 - Similar

Mouse, pancreas, adult

ESM000508 - Similar

Mouse, skin, adult

ESM000509 - Similar

Mouse, skeletal muscle, adult

ESM000510 - Similar

Mouse, salivary gland, adult

ESM000511 - Similar

Mouse, testes, adult

ESM000512 - Similar

Mouse, ovaries, adult

ESM000513 - Similar

Mouse B lymphocyte, spleen, activated (72 hr.)

ESM000514 - Similar

Mouse B lymphocyte, lymph node germinal center

ESM000515 - Similar

Mouse pro-B cell, bone marrow, adult

ESM000517 - Similar

Human centroblast, lymphoepithelial, child

ESM000538 - Similar

Human centrocyte, lymphoepithelial, child

ESM000539 - Similar

Human pre-germinal B cell, lymphoepithelial, child

ESM000540 - Similar

Human plasma cell, lymphoepithelial, child

ESM000541 - Similar

Human B lymphocyte, lymphoepithelial, child, naïve

ESM000542 - Similar

Human B lymphocyte, lymphoepithelial, child, B memory

ESM000543 - Similar

Total: 48 samples - View details

Experiments

Total: 51 experiments - View details

Data submission

Regulation of microRNA Expression and Abundance during Lymphopoiesis

Although the cellular concentration of miRNAs is critical to their function, how miRNA expression and abundance are regulated during ontogeny is unclear. We used deep-sequencing to characterize the microRNome from most developing lymphocytes, various hematopoietic cell lineages, and representative ...

Laboratory of Molecular Immunogenetics/National Institute of Arthritis and Musculoskeletal and Skin Diseases/National Institutes of Health. Public on: Jun 07 2010

GSE21630 - GEOSRA

microRNA expression in human tonsillar B cell populations

small RNA profiles of 6 human tonsillar B cell populatios (naive B cells, pre-germinal center B cells, centrocytes, centroblasts, memory B cells, and plasma cells) were determined by deep sequencing. These samples were compared to mouse developing lymphocytes, various hematopoietic cell lineages, ...

Whitehead Institute. Public on: Jul 24 2010

GSE23090 - GEOSRA

References

Global regulation of promoter melting in naive lymphocytes.

Kouzine F, et al. Cell. 2013 May 23;153(5):988-99. - Similar

Regulation of microRNA expression and abundance during lymphopoiesis.

Kuchen S, et al. Immunity. 2010 Jun 25;32(6):828-39. - Similar

Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes.

Yamane A, et al. Nat Immunol. 2011 Jan;12(1):62-9. - Similar

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