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THE FIRST SIGNS of ataxia telangiectasia (A-T) usually appear in the second year of life as a lack of balance and slurred speech. It is a progressive, degenerative disease characterized by cerebellar degeneration, immunodeficiency, radiosensitivity (sensitivity to radiant energy, such as x-ray) and a predisposition to cancer.
Back in 1988 the gene responsible for A-T was mapped to chromosome 11. The subsequent identification of the gene proved difficult: it was seven more years until the human ATM gene was cloned. The diverse symptoms seen in A-T reflect the main role of ATM, which is to induce several cellular responses to DNA damage. When the ATM gene is mutated, these signaling networks are impaired and so the cell does not respond correctly to minimize the damage.
Some of the ATM-dependent signaling pathways are found in yeast. Since these pathways appear to be conserved throughout evolution they are likely to be central to the DNA damage response. Research into finding an effective therapy for A-T sufferers is likely to be helped by harnessing the power of yeast genetics, which allows more rapid and systematic study of the pathways effected by an ATM mutation.