3DLB,2F8S,1Z25


Conserved Protein Domain Family
PIWI
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COG1431: PIWI 
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PIWI domain, catalyzes dsRNA-guided hydrolysis of ssRNA, involved in RNA silencing, RNA metabolism and antiviral defense [Translation, ribosomal structure and biogenesis, Defense mechanisms]
Links
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Statistics
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PSSM-Id: 441040
Aligned: 28 rows
Threshold Bit Score: 296.718
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3DLB_A         99 DPKDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLEVDPAYRILCEMS 178 
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WP_015898277   63 IPVVENAIAIGTETDFNIISDFQLANALARSALHRYFKAAGRETVIGFRPVTLLLEKHNLASNRKDVFGIFPEYTLDVRP 142 
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WP_083829967    1 MGTEPHQGSGPRVNVFRVDLETIRGELEGSPSINVYGLAFKEPIREDDPCIQALENIGYYDGGSRRLYTTRPIGDLPEPC 80  
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WP_101018292  335 IKSNLHPVVFPKEVFQFEIDYKDEKPWSFLKTICQVNNICAVPFKRKVFAIGTLTDISKAFNGLLKSDIKRESISKFDVE 414 
WP_099325248    1 -------------------------------------------MSTLLLNRTNLRFHLDKQWFVNIKNKEGFVITAKESQ 37  
WP_118505353  359 KFVKERTLLNNNITAVPYSKSIWSFGTLEEIQNTFKDVIQGDIVRKPLTDIKIYNSSMSFLLLSTLCKLFSNTNNLKTNY 438 

3DLB_A        179 LEAWLAQGHPLPKRVRNAYDRRTWELLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVADPKDPRKPIPHLT 258 
WP_011011654    1 -----------------------------------------------------mkakvvinlvkinkkiipdkiyvyrlf 27  
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WP_015898277  143 LAPHEGDIASGVLIGFGIKYVFLQNVAELQAQGVSAAGMYAVRLVDESEHQFDRAYLGRIDRFTKDNVTLVDSDYAEYPA 222 
WP_013299754    1 ------------------------------------------------------------------MSDKRPFGLTAHER 14  
WP_083829967   81 RDSVSLGSHKAVTLKEVPVDGIRSIIKVYVRDKVLRGSRAVLEESDEVGGILDEVLKGLTSKGYRNVRRSRSVFHVGRWN 160 
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WP_101018292  415 NVSAFKSLMLQAILKHFANDKRISTNNKNKIWLTSNESEYKSIKIHKALFLSFYFDKNKSFGYLTFTPTINLTSDQEISK 494 
WP_099325248   38 WLRNKIKNDEAKNNFNEWLKKNNIKDEDPVEIEFSLDRDNNSYFISSDNFDIKSLKRLIIKQELTNYFLDKGFYVDLNPT 117 
WP_118505353  439 KDKVWSESDYKTIHNQKVFNALRFALEKIKGKYYLSLNPDFYIENNNLTKDIKQQIGLAFFQKIWNKQYNNYVTNWRKKL 518 

3DLB_A        259 GLLVPVLTLEDLHEEEGSLALSLPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGF 338 
WP_011011654   28 ndpeeelqkegysiyrlayenvgividpenliiattkeleyegefipegeisfselrndyqsklvlrllkengigeyels 107 
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WP_015898277  223 DQCYFEGSRTNIEAVGRSLLGKDYDAFSSSLLQESYKVTGAPNQTQRLHQLGAWLEAKSPIPCAVGLGVRIAKKPHECSR 302 
WP_013299754   15 LREPLLRFGSTADNDVDVHPLRGLLRYGPYSRNWIAGVPDQIRIAMIGQQGMIGKMRGLVSELEATLRPRDAAAYRPDYQ 94  
WP_083829967  161 ARLTVDSNDVYVFWFNDELFVALNVGLDIDYNGNLWDHMAERSLDKLRSLVEHVRCRYILDIARGRPGTYVVANVIDRSS 240 
WP_049724747    1 ---------------------------------MAIFLNAFPLSIPDTELAALQIPYANETLNSFRRHYRSTHFFRRQGD 47  
WP_101018292  495 TDKLTISKHNLEKLYNNKYDEILENWNKLLFNKPRIKFEYPLQSGSGLEFQISSSTAFGEINVLDPKFRGYAPKEYDNKQ 574 
WP_099325248  118 AFDLSVYKRKEDFKTDWEIYIRYDLVYKSFNEELSISVGSEFTLISRKEIFQIDGIRKVVNIGNKLICKYEQILSGDSFK 197 
WP_118505353  519 FNQKKYEFPLNSGSGFTFGINKAPIFTNVCDLNNRYTNHHNVPEHLIKLKGVQFKETSLLFSTINGTKEAFDVHPMRGLV 598 

3DLB_A        339 YRAQETALALLRLDGAQGWPEFLRRA------------------------------------------------------ 364 
WP_011011654  108 kllrkfrkpktfgdykvipsvemsvikhdedfylvihiihqiqsmktlwelvnkdpkeleeflmthkenlmlkdiasplk 187 
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WP_015898277  303 GNDAGYSRFFDSPKCVLRPGGSLTVPwpvdkqidlngpydaesf------------------------------------ 346 
WP_013299754   95 GMSKTFGVRPVGAGSASEIILPDTLTddvrr------------------------------------------------- 125 
WP_083829967  241 YEEKSPPMGYEELVKYPVVKAREEGLetrferlmkklvgevdpnqpvleatragkmgrrpvyipaqycipvydprlaekh 320 
WP_049724747   48 NVLIFSETGDFPISGTSRTITFKNNFgifcslvkdgltrhlvglgrnpigfapielvsekpednllvpilgnaypfrica 127 
WP_101018292  575 TQFKGVQFLEPQLVFRNISSDMEFKDyhpmrglvnnrpydvnln------------------------------------ 618 
WP_099325248  198 VIADKQMRSGIEGANRVIPCSYKTEYknildflksglkdfesvffnidktgfktvldkdrqriilkdn------------ 265 
WP_118505353  599 NFKPFETSLNSFLDKTIDLGVICPDN------------------------------------------------------ 624 

3DLB_A            --------------------------------------------------------------------------------     
WP_011011654  188 tvykpcfeeytkkpkldhnqeivkywynyhierywntpeaklefyrkfgqvdlkqpailakfaskikknknykiyllpql 267 
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WP_083829967  321 edralaklrelvnsigykgklinaiarslgylseathl------------------------------------------ 358 
WP_049724747  128 rytidtriikgqpclvidcttrrvlresglyflnagfdlmgryvvneqddgyrrflgavsgcngevltvtrpdnqvmqvn 207 
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3DLB_A            --------------------------------------------------------------------------------     
WP_011011654  268 vvptynaeqlesdvakeileytklmpeerkellenilaevdsdiidkslseievekiaqelenkirvrddkgnsvpisql 347 
WP_010878815    1 -------------------------------------------------------------------------mmeykiv 7   
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WP_083829967  359 ----------------------------------------nieriegekplkvelveveynggkpsiinrskrevsftad 398 
WP_049724747  208 akelyleasrvnfedyilhthgnkkdvivecirqaiskfnsgknkkaridalknyfqsrdislidgtpikimeppdiesq 287 
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3DLB_A        365 ----------------------------------------------------LLRAF---------GAs----------- 372 
WP_011011654  348 nvqksqlllwtnysrkypvilpyevpekfrkireipmfiildsglladiqnfATNEFrelvksmyySLak---------- 417 
WP_010878815    8 engltyrigngasvpisntgelikglrnygpyevpslkynqialihnnqfssLINQLksqisskidEVwh---------- 77  
WP_015898277  347 -----------------------------------pnkrvriavicpqeftgDAEEFlrklkeglpNApdgspfr----- 386 
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WP_083829967  399 vmkplrlisivkeveegrrvkieipvpnyvpatlreldelqllvlvedgldpLSFEImdvvvenvtRLy----------- 467 
WP_049724747  288 cgqlqkpvfvfndngeaswaekgltqygpytkrtfdrndpsicvicaqqdkgRVEQFvrkllkgisRSkyfsng------ 361 
WP_101018292  619 -----------------------------------gvilsneinlsvicggkySNKFyaflsqlqtKHstdnknpdylid 663 
WP_099325248  266 ----------lmvfggenktvnavigmreygpykkidnandikilfiynerdDANKVyqylrnglkQFpgll-------- 327 
WP_118505353  625 ----------------------------------------------------DAENFynflskqnqEIqknnpddnyiid 652 

3DLB_A        373 --------GASLRLHtLHa--------------------hPSQGLAFREALRK-Ak-----EEGVQAVLVLTPPMAWE-- 416 
WP_011011654  418 ------kyNSLAKKArSTneiglpfldf--rgkekvitedLNSDKGIIEVVEQvSs----fMKGKELGLAFIAARNKLss 485 
WP_010878815   78 ------ihNINISEF-------------------------IYDSPHFDSIKSQvDna---iDTGVDGIMLVLPEYNTPl- 122 
WP_015898277  387 -kgfvrkyHLSSCDFtFHevkrs-------------snsdDIYKDASLEALKQ----------KPDMAIAIIRSQYRGlp 442 
WP_013299754  126 -----------------------------------arkpyVVLAEALQRAITQlKa----tRNDFDVVFIGIDAAWEPaf 166 
WP_083829967  468 --------EIVREVYePlkiklpkl--------rvhrqpilFTHGDYSNVLKEvRk-----VTGGKLAFAFILGERPAdd 526 
WP_049724747  362 ---legkfTLGTSHIdVFtttn---------------dsvDAYKNAIEAAIRQkAd----dGGRWDLALVQVRQSFKKln 419 
WP_101018292  664 ypgfssiyNIPLNIPyFEndgswldidfrgeneleahenaiKLARLITSKIEQiAn-----TQSQSTIVIFIPNEWQNfe 738 
WP_099325248  328 -----tyvGIPVVLDkEKsl-------------------yySSTGELSTKLQEfLaaqfpdNDYYNYAAVIIGPFSKY-- 381 
WP_118505353  653 fkgfyniyGVSLNIP-LKsssnwetlne--pinkthretvHEIKRNICDKITKlSt-----IGSQKIMVIYIPNRWEQfi 724 

3DLB_A        417 --DR--------NRLKALLLREGLPSQILNVP--LR--------EEERHRWENALLGLLAKAGLQVVALSG--AYPAELA 474 
WP_011011654  486 e---------kfEEIKRRLFNLNVISQVVNEDtlKNkrdkydrnRLDLFVRHNLLFQVLSKLGVKYYVLDY--RFNYDYI 554 
WP_010878815  123 -----------yYKLKSYL-INSIPSQFMRYDilSN--------RNLTFYVDNLLVQFVSKLGGKPWILNVdpEKGSDII 182 
WP_015898277  443 da------snpyYTTKARLMAQGVPVQLLNIEtiRR--------KSLDYILNNIGLAMYAKLGGIPWTLTQnsDMAHEII 508 
WP_013299754  167 -vERdeedfdlhDYLKAVGASMGVSVQLIRSDkaLDy-------HCRASVMWRLSIALYTKAGGVPWVLED--IHPQTAF 236 
WP_083829967  527 ee-------dyyRPLKKVLFKGNVISQNIDVRkyVSdgr--vdkRILMPAISNMFYDMLGKLGVKYLTLSK--STDYDLI 595 
WP_049724747  420 vn------enpyYWGKSLFFLHQIPVQDFTIEllEQs------dYSLGYSLNNMALACYAKMGGIPWLLKSspTLSHELV 487 
WP_101018292  739 sfVNkeesfdlhDYVKAFAASKGIATQLIREKtlED--------NLTCQINWWLSLSFYVKSLRTPWILNN--QEKNTAY 808 
WP_099325248  382 --ESdeeeektyYEIKKLLLDKGITSQFIANKtvRS--------GNFNYCLPNIAIAILAKLGGIPWKLNT--KKYNDLV 449 
WP_118505353  725 hyNDgvesfdlhDYVKAFCAEKGVTSQFIREKtiLDn-------SQSCQINWWLSLSYFVKSFRTPWIINN--TNKTTAF 795 

3DLB_A        475 VGFDAG--G----RESFRFGGAACAVGGDGGHLLWTLPEA--------QAGERIPQEVVWDLLEetlw-afrrKAGRLPS 539 
WP_011011654  555 IGIDVApmK----RSEGYIGGSAVMFDSQGYIRKIVPIKIg------eQRGESVD---MNEFFKemvdkfkefNIKLDNK 621 
WP_010878815  183 IGTGATr------IDNVNLFCFAMVFKKDGTMLWNEISPIv-------TSSEYLTY--LKSTIKkvvygfkksNPDWDVE 247 
WP_015898277  509 VGIGSArlNesrrGAGERVIGITTVFSGDGQYLLANNTQEv-------PSEEYVDA--LTQSLSetvs-elrsRFGWRPK 578 
WP_013299754  237 IGIDYAmrRvq-dDGPRFAICCAQVFDAEGSGLEFIAYKAdgv--svyGDNPYLNHAQMLKIIArsltiyqrkHYGDLPK 313 
WP_083829967  596 IGVDVGhgE----VEGSRIVGSVVLFDKMGRLMNLVPVYGlg-----yPGRETAR---IGDLLEqie---yenYAELKGK 660 
WP_049724747  488 IGIGSAniGqkrgFENQRIMGITTVFSGDGSYIVSNTSKAv-------VPEAYCEA--LTSVLDetig-kiqkRMNWQKG 557 
WP_101018292  809 AGIGYSisKik--dKSEIVIGCSHIYDSNGQGLKYKLSKIdnyf-ldkQNNPFLSFKDAFQFGVsire-lfyeSLDKLPE 884 
WP_099325248  450 IGYNYKk------LQDQKWIGSAVFFDNEGRLGRIYGFSEe-------RAGED-----LISHLKiaid-dyskSIG-SPD 509 
WP_118505353  796 AGIGYSinNkndeNDSHIVLGCSHIYSSTGEGLRYKLSKIsndkiqwrNRKPHLSYDDAYEFGRsvln-lfyeSMNEVPK 874 

3DLB_A        540 ---RVLLLRDG---RVPQDEFALALEALA--------REGIAYDLVSVR--KSGGGRVYPV---QGRL---------AD- 590 
WP_011011654  622 ---KILLLRDG---RITNNEEEGLKYISE--------MFDIEVVTMDVI--KNHPVRAFANm------------------ 667 
WP_010878815  248 ---KLTLHVSGkrpKMKDGETKILKETVEelkkqemvSRDVKYAILHLN--ETHPFWVMGDpn-------------nRFh 309 
WP_015898277  579 drvRFIFHQKFk--KYKDAEAEAVDRFARsl-----kDFDVQYAFVHVS--DSHNWMLLDP---ASRGvkfgdtmkgVAv 646 
WP_013299754  314 ---RVVIHKNT---PFRDEEVDGCLNALS--------SVD-AVELIQVQ--QDTGWRGYRV---DAAQkv------aGYp 367 
WP_083829967  661 ---RILVLRDG---RLTKEEVTQLADISR--------TKDCTIEVINVK--KRTPFQQLSDsr----------------- 707 
WP_049724747  558 dtiRLVFHAQVk--KFSKDEIAAVQAVIEky-----rEYQVEYTFLKIS--ENHSLHMFDS---TSAGer-----kgRLa 620 
WP_101018292  885 ---RVVIHKRT---KFTQEEIDGIKASLHk-------AGIKKIDLIEIS--FEPDARFVAMsvyNKELqv------dKFp 943 
WP_099325248  510 ---RLTIHYYK---PPRKDEIKNFEQVIYnk-----lNLDIPFALTEVNdtKSKSDICFDTey-------------dMGm 565 
WP_118505353  875 ---RVVIHKRT---FFTEEEKQGILDSLYd------nKKIENIDLIEIN--FEDDIRYVSSkiyNGKAdi------dGFs 934 

3DLB_A        591 ---GLYVPLEDKTFLLLT--Vh-----------RDFRGTP-----RPLK--LVH-----EAGDT-----PLEALAHQIFH 637 
WP_011011654  668 ---KMYFNL-GGAIYLIPhkL------------KQAKGTP-----IPIK--LAKkr-iiKNGKVek-qsITRQDVLDIFI 722 
WP_010878815  310 pyeGTKVKLSSKRYLLTLlqPy-----------LKRNGLEmvtpiKPLSveIVS-----DNWTSeeyyhNVHEILDEIYY 373 
WP_015898277  647 pqrGQCVPLGPNAALLTLsgPfq--------vkTPLQGCP-----HPVLvsIHE-----KSTFK-----SVDYIARQIFN 703 
WP_013299754  368 verGSLMPIGAHEALLWSrgDlpdvalrgahyfKEGKGTP-----EPLL--ITR-----HAGRG-----DFGDVCSDTLG 430 
WP_083829967  708 --vAWFVDI-GDAYLLKThmL-------------KRDMLP-----RPIK--IDKvkyvfAKGTVre-erVSVDDLRLLRG 763 
WP_049724747  621 pqrGKTFKLSKHEILVYLigQre--------lrNDTDGHP-----RGLIldVHK-----ASTFT-----DIKYLSAQVHS 677 
WP_101018292  944 isrGTCIVTNKHTALLWThgIvpsvrqpnykfyLGGRSIP-----APVK--ITK-----HYGES-----NIDLISTEILS 1006
WP_099325248  566 pesGTYVKIGKDEYLLFNnnR------------YEKEPVRkvkdeLPIKvkIFHa----DVGGF-----SHREILSQVYE 624 
WP_118505353  935 vsrGTCIQLNEKEALLYShgVipsvknpkynfyPGGRYIP-----KPLK--IIK-----HYGTG-----SLEQIANEILG 997 

3DLB_A        638 LTRLYPASGFAf--PRLPAPLHLADRLVKEVGRlGirh--------lkEVDREKLFFV 685 
WP_011011654  723 LTRLNYGSISAd--MRLPAPVHYAHKFANAIRN-Ewki-------keeFLAEGFLYFV 770 
WP_010878815  374 LSKMNWRGFRS---RNLPVTVNYPKLVAGIIAN-VnryggypinpegnRSLQTNPWFL 427 
WP_015898277  704 LSFISWRGFNP---STLPVSISYSDMIVDLLGH-Lrrvknw-npetlsTALKERRWFL 756 
WP_013299754  431 LTKMDWNNDGPy--DGMPVTLNYAGRLAQIVKR-Mpd---------lqPHPYPVRLFM 476 
WP_083829967  764 LSHLNYSTIEGetgLRLPAPVHYADKLLDALRS-Gwei-------errYLRDGLLYFL 813 
WP_049724747  678 FASHSWRSYFP---NPLPVTISYSDLIARNLGW-Lnqipgw-sdsvmiGKIGHSQWFL 730 
WP_101018292 1007 LTKMNWNSLDLy--SKLPSTIDSSNKIARIGKL-Lsr---------feGRTYDYRLFI 1052
WP_099325248  625 FSRLNWKGLMQ---TSQPVTTKYSKMIADFSLH-Fngei------senKISQKTPWFI 672 
WP_118505353  998 LTKMNWNSLNMy--SQLPATISSSNEIARIGKL-Ies---------reKVEYDYRYFM 1043
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