1RXV,1MC8,1A76


Conserved Protein Domain Family
fen_arch
?
TIGR03674: fen_arch 
Click on image for an interactive view with Cn3D
flap structure-specific endonuclease
Endonuclease that cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Has 5'-endo-/exonuclease and 5'-pseudo-Y-endonuclease activities. Cleaves the junction between single and double-stranded regions of flap DNA
Links
?
Statistics
?
PSSM-Id: 274717
Aligned: 27 rows
Threshold Bit Score: 451.319
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
1RXV_A         1 MGA-DIGDLFEREEVELEYFSGKKIAVDAFNTLYQFISI-IRQPDGTPLKDSQGRITSHLSGILYRVSNM-VEVGIRPVF 77  Archaeoglobus f...
Q9HQ27         1 MGNaDLRQLAAIEETPFADLEGSVVAVDAHNWLYKYLTTtVQWTGADVYTTSDGTEVANLVGAVQGLPKF-FEHGLTPVF 79  Halobacterium s...
Q58839         1 MGV-QFGDFIPKNIISFEDLKGKKVAIDGMNALYQFLTS-IRLRDGSPLRNRKGEITSAYNGVFYKTIHL-LENDITPIW 77  Methanocaldococ...
Q2NFD4         1 MGV-KFKDITNPEPIEMKELEGKILTVDASNVIYKFLSS-MRQTDGTPLRDLNGHITSHLNGIMFQTSTL-IEKDIKPVY 77  Methanosphaera ...
O27670         1 MGV-KLRDVVSPRRIRLEDLRGRTVAVDAANTLYQFLSS-IRQRDGTPLMDSRGRVTSHLSGILYRTAAV-MEREIRVIY 77  Methanothermoba...
Q6L2I9         1 MGV-NLSSILIKHETSLKDNSGSIVSVDAYNIIYQFLSS-IRGDDGEPLKDSNGNITSHLSGIFYRTSNL-LENNIKPVY 77  Picrophilus tor...
Q9HJD4         1 MGT-DISDIVVSHETSLKDQGNQTFSIDTYNILYQLLSN-VRQYDGMPLMDSHGNVTSHLYGIFYRTINL-LENRIRPVY 77  Thermoplasma ac...
WP_011752100   1 MGV-NLTPLVKPKKIGLQGVRGRVLAVDALNSVYQFLAL-VRDERGMLFTNSRGEVTSHLIGLLSRYSRLaYEYDASFIF 78  Thermofilum pen...
WP_011222786   1 MGNaDLRSLAALSDVSFDDLGGSVVAVDAHNWLYRYLTTtVKFTSESKYTTSNGEEVANLIGVVQGLPKF-FEHDMTPVF 79  Haloarcula mari...
WP_011868051   1 MGV-QFGDLIPKTEISLKFLKNKTVAIDAMNVIYQFLSS-IRLRDGSPLKNKNGEITSTYNGIFYKTIYM-LENEMTPIW 77  Methanococcus m...

1RXV_A        78 VFDGEPPEFKKAEIEERKKRRAEAEEMWIAALQAGDK-DAKKYAQAAGRVDEYIVDSAKTLLSYMGIPFVDAPSEGEAQA 156 Archaeoglobus f...
Q9HQ27        80 VWDGGVTELKDDEIADRREQRERYEEQLDDAREAGDAaEAARLDARTQRLTPTIHETTRELFDLLDIPQVEAPAEGEAQA 159 Halobacterium s...
Q58839        78 VFDGEPPKLKEKTRKVRREMKEKAELKMKEAIKKEDFeEAAKYAKRVSYLTPKMVENCKYLLSLMGIPYVEAPSEGEAQA 157 Methanocaldococ...
Q2NFD4        78 VFDGKAPDLKKETQEERINIKKESEKKYLEAKEVGDVvAARKYAARTTHLNKEIIKSSKKLLDLMGIPYVQARTEGEAQA 157 Methanosphaera ...
O27670        78 VFDGRSHHLKGETVSRRADIRKKSEVEWKRALEEGDIdRAKKYAVRSSRMSSEILESSKRLLELLGIPYVQAPGEGEAQA 157 Methanothermoba...
Q6L2I9        78 VFDGKPFHLKSETLRERSLIKEKNIMKLEEAIASNDDaKIRSLSSRINYITDDIVNESKTLLNLMGLPYVQAPSEGEAQA 157 Picrophilus tor...
Q9HJD4        78 VFDGKPSPLKNRTISERQMMKEKAKAELEEAIERGEE-DLRQYYSRINYITPQIVDDTKKLLDYMGIPYVDAPSEGEAQA 156 Thermoplasma ac...
WP_011752100  79 VFDGSPHPLKARELEKRKKQREKAKQEYAELLSKGDLrKAFSKAVVSAEVDDRIVESTKRLVRLMGFPVVDAVHDAEAQA 158 Thermofilum pen...
WP_011222786  80 VFDGAVTDLKDDEVEKRREQRQKYESELEAAREAGDStRVAKLDSRTQRLTDTIVDTTRDLLELLDVPIVDAPAEGEGQA 159 Haloarcula mari...
WP_011868051  78 VFDGKSHDLKEKTKEERRKSRNGALDSYLEAKEQNNLeEMQKYAKRANFLDKKTIDNSKKLLELMGIPYINAPSEGEAQC 157 Methanococcus m...

1RXV_A       157 AYMAAKGD-VEYTGSQDYDSLLFGSPRLARNLAITGKRKLPGKNVYVDVKPEIIILESNLKRLGLTREQLIDIAILVGTD 235 Archaeoglobus f...
Q9HQ27       160 AYMTRTDDaVDYAGSDDYDCLLLGSPVTLRQLTSSG-------------HPELMDFDATLAEHDLTWEQLVDVGILCGTD 226 Halobacterium s...
Q58839       158 SYMAKKGD-VWAVVSQDYDALLYGAPRVVRNLTTTKE------------MPELIELNEVLEDLRISLDDLIDIAIFMGTD 224 Methanocaldococ...
Q2NFD4       158 SYMVSQND-AWAVVSQDYDCLQFGATRMIRNLKLSKSNSK---------NLELISLEKTLKELNLTREQLVDVAMLVGTD 227 Methanosphaera ...
O27670       158 SYMVKMGD-AWAVASQDYDCLLFGAPRVVRNLTLSGKLE----------DPEIIELESTLRELSISHTQLVDMALLVGTD 226 Methanothermoba...
Q6L2I9       158 SYMTLKGD-VNAVVSQDYDCLLFGAKRILRNFTVYGRRRIAGTSRTINVNPEIIDLNENLSNLGISREQLIYIGILTGTD 236 Picrophilus tor...
Q9HJD4       157 SYMTKKN--VDGVISQDYDCLLFGARKILRNFAIYGRRKVPRKNIYKTVYPEYIILDEVLSANQINQDQLIGIGILVGTD 234 Thermoplasma ac...
WP_011752100 159 AYLVKRGE-AWAVSSMDWDSLLYGSPRLVRYLTLTGFEWLPSKQKARKLIPELVTLEELLSGHGITLRQLVDIAILVGTD 237 Thermofilum pen...
WP_011222786 160 SVMARRGD-VDYVGTEDYDALLFGAPMTLRQITSKG-------------DPELMDFAATLEHHDLTWEQLVDAAILMGTD 225 Haloarcula mari...
WP_011868051 158 AELVKSND-AFCVISQDYDSILYGAENVVKNITSSNK------------DIELIELEKTLSELNVSLDQLIDVAILIGTD 224 Methanococcus m...

1RXV_A       236 YN-EGVKGVGVKKALNYIKTYGDIFRALKA-LKVNID-HVEEIRNFFLNPPVTDDYRIEFR-EPDFEKAIEFLCEEHDFS 311 Archaeoglobus f...
Q9HQ27       227 FNp-GIDGFGPTTALDAIGEHGDLWDVLAA-EGEHVA-HGDRIRELFLNPDVTDDYVIDPDvSPAIDAARAFVTDEWEVD 303 Halobacterium s...
Q58839       225 YNpGGVKGIGFKRAYELVRS-GVAKDVLKK----EVE-YYDEIKRIFKEPKVTDNYSLSLK-LPDKEGIIKFLVDENDFN 297 Methanocaldococ...
Q2NFD4       228 FN-KGVYGIGAKKGIKLIHKYGTLEKALES-LNETMEvDAELIREIFLNPNVVHNYTIEFK-RPKKSQLLDFLCGEHDFD 304 Methanosphaera ...
O27670       227 FN-EGVKGIGARRGLKLIREKGDIFKVIRD-LEADIGgDPQVLRRIFLEPEVSEDYEIRWR-KPDVEGVIEFLCTEHGFS 303 Methanothermoba...
Q6L2I9       237 FNp-GVKGIGAKTALSLIKKYNDIYSVIKI-KNIGID-NLDEIIEFFMNPPHND-YEIKFN-EPDFDGIIDFLCGKHNFS 311 Picrophilus tor...
Q9HJD4       235 FN-EGIKGIGAKKALALIKKEGDIKSVLKH-IGKNIE-NLDEIIDFFKNPPVVD-YDFKFR-KPDTDAIEHFLCDEHDFS 309 Thermoplasma ac...
WP_011752100 238 YN-EGVKGVGPLRALKMIKRYGSLENLPVSvRRHLPE-NYEAVRQIFLNPPLNEKYSLSFS-PPDKEGLMKFLVDENDFS 314 Thermofilum pen...
WP_011222786 226 FN-EGISGIGPKTAVKDLHEHGDLYTVLAA-RGEHID-HADRIRDLFLDPAATDDYEIPDSiEPDIDAARTFVTDQWEVD 302 Haloarcula mari...
WP_011868051 225 YNpGGLKGFGPKKAIDTVKK-GKMENYISE-----IE-NYSEIRKIFDEPNVTSEYDTKLK-TPKKEELAEFLIEENDFS 296 Methanococcus m...

1RXV_A       312 RERVEKALEKL-KAl--KSTQATLERWF 336 Archaeoglobus fulgidus DSM 4304
Q9HQ27       304 ADAVARGFERIdAA----AAQTGLDRWT 327 Halobacterium sp. NRC-1
Q58839       298 YDRVKKHVDKLyNLianKTKQKTLDAWF 325 Methanocaldococcus jannaschii DSM 2661
Q2NFD4       305 ERRTISAIKKLqAK----TAQSSLEDWF 328 Methanosphaera stadtmanae DSM 3091
O27670       304 EDRVRAALKKFeGA---SSTQKSLEDWF 328 Methanothermobacter thermautotrophicus str. Delta H
Q6L2I9       312 ESRVNETLEKIsRNy-kKDHQSSLDRFF 338 Picrophilus torridus DSM 9790
Q9HJD4       310 RERIRDHLESLrKNd-qASTQFRLDSFD 336 Thermoplasma acidophilum DSM 1728
WP_011752100 315 PKRVEVYLRRLeAAy--ERRKGGLTRFL 340 Thermofilum pendens
WP_011222786 303 ADEVARGFERIdDS----VVQTGLDRWa 326 Haloarcula marismortui
WP_011868051 297 KDRILPNIEKIsNLlgnKKSQKSLEAWF 324 Methanococcus maripaludis
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap