1Z6Z


Conserved Protein Domain Family
sepiapter_red
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TIGR01500: sepiapter_red 
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sepiapterin reductase
This model describes sepiapterin reductase, a member of the short chain dehydrogenase/reductase family. The enzyme catalyzes the last step in the biosynthesis of tetrahydrobiopterin. A similar enzyme in Bacillus cereus was isolated for its ability to convert benzil to (S)-benzoin, a property sepiapterin reductase also shares. Cutoff scores for this model are set such that benzil reductase scores between trusted and noise cutoffs.
Links
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Statistics
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PSSM-Id: 273660
Aligned: 4 rows
Threshold Bit Score: 388.501
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1Z6Z_A    27 AVCLLTGASRGFGRT-LAPLLAs--LLSPGSVLVLSARNDEALRQLEAELG--AERSGLRVVRVPADLGAEAgLQQLLGA 101 human
AAD12760   7 TYLLVTGASRGIGREfAQQLAKr--IKAEGSMVTLLGRNQTLLQESKAEIV--ATVPDLSVQTYSLELETAK-TEDFTKI 81  fruit fly
AAF67740   2 VLAIVTGASKGFGKAiAQEIVKcnpNKNQLIDLVLFARSLDGLKSTKESIEtiS-TNAKVIDLQSLDMSNIPdVELKFKS 80  Dictyostelium disco...
P35270     8 AVCLLTGASRGFGRTlAPLLAS---LLSPGSVLVLSARNDEALRQLEAELG--AERSGLRVVRVPADLGAEAgLQQLLGA 82  human

1Z6Z_A   102 LRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPds---pGLNRTVVNISSLC 178 human
AAD12760  82 LEASGGKNNFERAIVIHNAGTVGDTSKRAKEIGDTDFLQRYYHSNVFSAISLNCEFMRVFK------GIPKLVVNLSTLA 155 fruit fly
AAF67740  81 VLENIKWEEYSKICFFNNHGTLYHLGRIEd-FSDFKNIQKDNDTNTTSFVVTTSLLVKKLKelgsqySSEVTIVNSSSLC 159 Dictyostelium disco...
P35270    83 LRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPds---pGLNRTVVNISSLC 159 human

1Z6Z_A   179 ALQPFKGWALYCAGKAARDMLFQVLALEE---PNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKV 255 human
AAD12760 156 AIAPISSMAHYCTVKAAREMYFRVLATEEs-aEDTLVLNYAPGVIDTQMTVQVQREAHDPAVVAMFREQRESKTMLTPAQ 234 fruit fly
AAF67740 160 AIKAFPTWSLYCSSRAYRDMFFQALSLEYklnDKFKVLNYSLGVLDTDMQSQVREECSe-DDKSFYVGLKNDGKLINPNR 238 Dictyostelium disco...
P35270   160 ALQPFKGWALYCAGKAARDMLFQVLALEE---PNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKV 236 human

1Z6Z_A   256 SAQKLLSLLEKDEFKSGAHVDFYD 279 human
AAD12760 235 TTERFIKVLEAFKFKSGDHVDYRD 258 fruit fly
AAF67740 239 SASICSNLVYSHKFETGSHLDYYD 262 Dictyostelium discoideum
P35270   237 SAQKLLSLLEKDEFKSGAHVDFYD 260 human
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