2NRA


Conserved Protein Domain Family
Rep_3
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pfam01051: Rep_3 (this model, PSSM-Id:395835 is obsolete and has been replaced by 460042)
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Initiator Replication protein
This protein is an initiator of plasmid replication. RepB possesses nicking-closing (topoisomerase I) like activity. It is also able to perform a strand transfer reaction on ssDNA that contains its target. This family also includes RepA which is an E.coli protein involved in plasmid replication. The RepA protein binds to DNA repeats that flank the repA gene.
Links
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Statistics
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PSSM-Id: 395835
Aligned: 161 rows
Threshold Bit Score: 36.1038
Created: 22-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2NRA_C                 11 KKTKIRHRNELNHTLaq--------lPLPAKRVMYMALALIDSKEPLERGrvfkiraEDLA-------ALAkItpslaYR 75  Escher...
Q7WWW9                 19 RGQSVTEAPKDLGFRrsnafvkiidlSLAGRRLIDVAYFLVAEDQEVRRE-------YRVDvglfkwlLATtSnnrrhLS 91  Cupria...
EAY25477               13 QDARVTLSNKFLL-------------SEMEINIFYLLVSQIRQDDDDLKEyvi--nlKDLEllt--grTQKkGtllkvCE 75  Micros...
wugsc:KPN_pKPN4p07092  20 NKKLMPSRNATVQPV-----------ALMRLGLFLPSLKRKGKDTENi--------sIDASselqsleLARaEg----YT 76  Klebsi...
Q8E8A8                 20 GKLLTISSTTSVQPN-----------VLLRTGVFTPVGRRTNANDVk---------aQDLSndlvnldVCQkEg----YD 75  Shewan...
WP_011906524           17 THQLTVTSNSSVQPA-----------ILLRLGVFVPASRAIPKGLKs---------gIDVSssfsqleFARkEg----YD 72  Entero...
Q71TA8                 18 AKELTVNSNNTVQPV-----------ALMRLGVFVPKPSKSKGESk----------eIDATkafsqleIAKaEg----YD 72  Escher...
Q6U5J6                 22 VVKLDVNSTSTVQPV-----------ALMRLGLFVPTLKSTSRSKANRKn------vTDATeelvqlsIAKsEg----YT 80  Klebsi...
CAS07437                8 VVNLTPNASNTVQPV-----------ALMRLGVFVPTLKSLKNSKKNTLs------rTDATeeltrlsLARaEg----FD 66  Escher...
O68759                 25 VVTLVPNTNNTVQPV-----------ALMRLGLFVPTLKSTSRGRKGQMvsm---daSAELkq---lsLAKaEg----YE 83  Yersin...

2NRA_C                 76 QLKEGGKLLGaSKIsLRGddiialakelnllstaknsseeldlniieWIAYSPDEGYLSLKFTRTIEPYISSLigkKNkF 155 Escher...
Q7WWW9                 92 KLVREAQKAAiELNeIDVedpskdrw--------------gavplmgSAFIEK--GEFIFELPERLQRAIKNP---KS-- 150 Cupria...
EAY25477               76 KLKKQTIVL--KDV-VSVtdgkeyef--------------ivenligAIKKPKNKQEIRTTISPDVRQFYINL---KKhY 135 Micros...
wugsc:KPN_pKPN4p07092  77 DIRITGPRLSmETD-FKV-----------------------------WVGIILAFSKYGL-NSSTIELPFSEF---AT-F 121 Klebsi...
Q8E8A8                 76 LVTVRGQRLNiETD-FKV-----------------------------WCGIVLVFSKYGY-SSNTVKLTFSEF---AK-F 120 Shewan...
WP_011906524           73 EVRIFGERLNiSTD-FSV-----------------------------WMGIIGAFSKYGL-KSNTIELPFTEF---AA-L 117 Entero...
Q71TA8                 73 DIKITGPRLDmDTD-FKT-----------------------------WIGVIYAFSKYGL-SSNTIQLSFQEF---AK-A 117 Escher...
Q6U5J6                 81 DVKITGSRLDmDTD-FKV-----------------------------WLGIIRSMSEYGV-KSDTLELSFVEF---VK-M 125 Klebsi...
CAS07437               67 KVEITGPRLDmDND-FKT-----------------------------WVGVIHSFARHKV-IGDKVELPFVEF---AK-L 111 Escher...
O68759                 84 DIRISGVRLDmDND-FKT-----------------------------WVGIIhAFAKHKV-VGDTVTLPFVEF---VR-L 128 Yersin...

2NRA_C                156 TTQLLTASLR-LSSQYSSSLYQLIrkhy-------------------snfKKKNYFIISV-------D-----------E 197 Escher...
Q7WWW9                151 SHFLSLRYVF--KSVHSKVLYDRLqqfm--------------------vegiTPW--FEV-------Q-----------A 188 Cupria...
EAY25477              136 NKFQLKNLLQ-LKGRHSKRLYMILca-----------------------fQDTGWYYASI-------D-----------E 173 Micros...
wugsc:KPN_pKPN4p07092 122 CGFSSKDKDKgLRTRLADSLIRLRsttiklasekdr--ngvvsgllsrgkWDEKDDIMELtadeslwElyqfd-rqvllQ 198 Klebsi...
Q8E8A8                121 CSYPSRRFDKnLRKQIGDSLGRIQsqslsfrrknse--kavhtgmllramYDGEEDIVELmadetlwDlyrld-yqvlvS 197 Shewan...
WP_011906524          118 CQYDSRQFNKrLRDTIFDALTRIGtktvqfnskktg--dkfftqllksgkYTKDTDTITLqaderlhElyqid-ynillR 194 Entero...
Q71TA8                118 CGFPSKRLDAkLRLTIHESLGRLRnkgiafkrgkdak-ggyqtgllkvgrFDADLDLIELeadsklwElfqld-yrvllQ 195 Escher...
Q6U5J6                126 CGFDSRRSNKkMRDRISNSLFKLAsvtlqfqsetk----gwtthlvqsayYDINEDIVEIkaepklfElyhmd-rrvllR 200 Klebsi...
CAS07437              112 CGIPSSQSSRkLRERISPSLKRIAgtvisfsrttekhtkeyithlvqsayYDTEKDIVQLqadprlfElyqfd-rkvllQ 190 Escher...
O68759                129 CGIPTARSSAkLRKRLDSSLTRIAtntisfrskgsd--eyyvthlvqtakYSTKNDTVSL-------QadpkifelyqfD 199 Yersin...

2NRA_C                198 LKE--------EL-IAytfdk--------------dgnieYKYPDFPIFKRDVL-NKAIAEIKK--------KtEIsFVG 245 Escher...
Q7WWW9                189 LRA--------WLeCEk-----------------------KTYDLFKHFRSKVL-EVAISE-----------IrEVtGLH 225 Cupria...
EAY25477              174 LLN--------IFaSKvgedg--------------qievkKYTAGS--LKKHIL-GKAKEE-----------IeDVtELR 217 Micros...
wugsc:KPN_pKPN4p07092 199 MFIirqlankgTAqALytfie--------------slperPIPLSFARIKRRLMlTSPNNQQNRvinkaideLkAVgYLD 264 Klebsi...
Q8E8A8                198 LRVleklpraeVAqCLylyft--------------slpenPHPVSFERLRERLRlETSKKEANRkiktgiqkLeSIgYLS 263 Shewan...
WP_011906524          195 KRPyhmlkgkeVAqTLytyia--------------slpdnPAPIRFDRIIERLNlTSPVKEQNRlikaalkqLhDIgYIE 260 Entero...
Q71TA8                196 HHAlralpkkeAAqAIytfie--------------slpqnPLPLSFARIRERLAlQSAVGEQNRiikkaieqLkTIgYLD 261 Escher...
Q6U5J6                201 LKAidalqrkeSAqALytyie--------------slpqnPAPISMKRMRDRLNlTSNVYTQNHtvrkameqLrDIgYLD 266 Klebsi...
CAS07437              191 LKAinalkrreSAqALytfie--------------slprdPAPISLARLRARLNlKSPVFSQNQtvrrameqLrEIgYLD 256 Escher...
O68759                200 KKV--------LLqLRainelsrkesaqalytfieslppdPAPISLARLRARLNlTSRTITQNAtvrkameqLrEIgYLD 271 Yersin...

2NRA_C                246 FTVHek---egRK--ISKLKFEF 263 Escherichia coli
Q7WWW9                226 IEMLtlnvpgsKK--IGQVRFRL 246 Cupriavidus necator
EAY25477              218 FEIEekk--sgRK--VVGYKFNI 236 Microscilla marina ATCC 23134
wugsc:KPN_pKPN4p07092 265 GDVV-------KKdgEWHLIITR 280 Klebsiella pneumoniae subsp. pneumoniae MGH 78578
Q8E8A8                264 GSFA-------VK---NGEQYYL 276 Shewanella oneidensis
WP_011906524          261 YSIV-------KDgrTLTVLIHK 276 Enterobacter
Q71TA8                262 CSIE-------KKg-RESFVIVH 276 Escherichia virus P1
Q6U5J6                267 YTEF-------KR--GRATYFSV 280 Klebsiella pneumoniae
CAS07437              257 YTEI-------QR--GRTKLFCI 270 Escherichia coli O127:H6 str. E2348/69
O68759                272 YTEVkr---------gSSVYFII 285 Yersinia pestis KIM10+
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