1GT0,1J46,1I11,2LEF


Conserved Protein Domain Family
SOX-TCF_HMG-box
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cd01388: SOX-TCF_HMG-box (this model, PSSM-Id:238684 is obsolete and has been replaced by 438790)
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SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and transcription factor-like proteins, TCF-1, -3, -4, and LEF-1. They appear to bind the minor groove of the A/T C A A A G/C-motif.
Links
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Statistics
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PSSM-Id: 238684
Aligned: 25 rows
Threshold Bit Score: 97.3689
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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DNA binding
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:aromatic residues interact directly with the DNA backbone
  • Structure:2LEF_A, sequence-specific LEF-1 binds TCR-alpha enhancer
    - View structure with Cn3D
  • Citation:PMID 7651541
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         # ## ##  ##  #   #       #    #  #  #                  #             
1GT0_D       2 RVKRPMNAFMVWSRGQRRKMAQENPkmHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYR 73   house mouse
2LEF_A       2 HIKKPLNAFMLYMKEMRANVVAESTlkESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSAR 73   house mouse
AAD45010   315 HIKKPLNAFMLYMKEMRASVVKECTlkESAAINQILGRRWHALTREEQAKYYELARKERQLHMQLYPGWSAR 386  purple sea urchin
AAK58836   349 HIKKPLNAFMLYMKEMRAKVVAECTlkESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSAR 420  African clawed frog
AAD11988    44 HIRRPMNAFMIFSKRHRALVHQRHPnqDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWC 115  human
Q9U1H0     489 KIRRPMNAFMIFSKKHRKMVHKKHPnqDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWKWC 560  fruit fly
T25144     250 HVRRPMNAFMIFSKRHRPLVHQQYPnkDNRTVSKILGEWWYSLAADQKAEYHKLATQVKEAHFKAHPDWKWS 321  Caenorhabditis elegans
AAL68984    79 RARRPMNAFLLFCKRHRSLVRQEHPrlDNRGATKILADWWAVLDPKEKQKYTDMAKEYKDAFMKANPGYKWC 150  human
AAH43817    77 RARRPMNAFLLFCKRHRSLVRQEHPrlDNRGATKILADWWAYLDPNEKQKYTDMAKEYKDAFMKANPGYKWC 148  African clawed frog
NP_728420  296 HARRPMNAFLIFCKRHRGIVKERYKtlENRAITKILGDWWAALDEQEKHCFTDLAQQNKDAFFNANPNFKWY 367  fruit fly

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