Conserved Protein Domain Family
LFG_like

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cd10428: LFG_like 
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.
Statistics
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PSSM-Id: 198410
Aligned: 32 rows
Threshold Bit Score: 203.157
Created: 27-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9BWQ8        92 SWDDQKVRRVFVRKVYTILLIQLLVTLAVVALFTFCDPVKdyv-qanPGWYWASYAVFFATYLTLACCSGPRRHFPWNLI 170 human
NP_001070536  80 PFSETAVRRDFIVKVLFLLSIQLLITGAIVSLFVFWKALRswv-vknPWFTYTLLPAFFVVFIVLACCGNLRRQVPANYI 158 cattle
NP_083417     84 PFENTSIRNDFIMKVFVVLSIQLFITAVIIGIFVFCEPVRkwv-iakPWFLYALLPAVMILIFVLACCRDIRRQVPANYI 162 house mouse
EEA97072      43 RIFTKEIRQGFIRKVYAIIAMQLILTAAVTSLFLFVDPIRtwfllhgQPVFIVATVVLFATTIPLLCCDGVLRRFPYNYL 122 Toxoplasma gond...
NP_001120085  64 PFSESAIRRAFIRKVYLTLAMQLALTVGLICMFIFWKRLKnwv-qeyPYIVYALCPAIIILALVLACCQQVRRKVPYNFI 142 western clawed ...
XP_003222024 121 PFSDKTARRVFLRKIYLMLTIHLSVTVGIICMFIYWKYLTiwv-rrrPWFSYTLVPALLILAIALACCDHARRKFPLNII 199 green anole
XP_003249414  68 DFKEDVVRRIFIRKVFCILTLQLLFTSGVIAIFLFVDSARkfm-iihWYLWIVAMICFAISFCAISFFEGARRSPPFNYL 146 honey bee
EDW32550      84 HFDDQTIRKGFIRKVYSILLVQLLFTCGTIALFLYHEPTKmfv-qknPVVLIVAAVLNIIVLIMIVCIEGVRRAHPTNLV 162 Drosophila pers...
EEE22290     122 PDVDRAIRHAFVRKVYVILSIQVLFTFGVAAAFTLVDPMRtwl-rlnSWCPVAFSFAGLILMIFVTCFPDLGRRVPLNFI 200 Toxoplasma gond...
NP_724626     54 VFEDPTIRMGFVRKVFGILLAQLLFTLAVIAIFSYHQPTKdfm-henFLLVLVAMIVNIIVLSTIVCVENVRRRHPVNLI 132 fruit fly
Q9BWQ8       171 LLTVFTLSMAYLTGMLSSYYNTTSVLLCLGITALVCLSVTVFSFQTKFDFTSCQGVLFVLLMTLFfsgliLAILLPFQYV 250 human
NP_001070536 159 LLGLFTVLQGLLLGTVSVFYHVEEVLWATAATALVTLSLSLFDLQTKWDFTLLNGMLFVLLFVLIi----YGIILIFIRA 234 cattle
NP_083417    163 LLAFFTILEGLLLGSLSVFYRAEEILWAAGATTMVTLVLTLFALQTKWDFTLLNGVMFVFTSVLLi----YGIIALVIRS 238 house mouse
EEA97072     123 LLCAFTLAESILVAGVTAHYSEKTVLIAVAGTAVITIGLSLFACQVKYDFTSWVGVLFILTLNLM-----IFGIFCIFLP 197 Toxoplasma gond...
NP_001120085 143 FLGLFTAVEGCMLGTIAALFDADAVMWAGGATIVVTLGLTIFALQTKWDFTMLSGGLCVALLVLLc----FGILCGILRS 218 western clawed ...
XP_003222024 200 LLLIFTMLEGTLLGSIAVFFDAESVMWTVAATTVIMFGFSIFLLQSKWDLTITSGILFILCFVVVi----FGLLAAILQS 275 green anole
XP_003249414 147 WLCILTIAMSYLAAFVSAFYEIEIILMALGMTTLITLGISLIATFTKFDLTMRTGILFIIGLAAIvsifvLIITLMFTYI 226 honey bee
EDW32550     163 CLGIFTVTMSLMLGCVSSVMNANLVLIAVGVTAFLVIGLSVYAIQTKVDYTAMGGVLVTFVMCIIi----FGLSNMLMPS 238 Drosophila pers...
EEE22290     201 LLSLITGCFSMMIAFGGAATESDAFFLAVGITFVVVLALTVFACQTKIDFTGCGPYILVAMICLMm----FGIFCIFWYN 276 Toxoplasma gond...
NP_724626    133 CLALYTFTMSLLLGTASSQMDSNVVISAVAITTLLVIALSIYAVQTKYDYTAAGGVILTFVIILIv----LSVCGVWMPD 208 fruit fly
Q9BWQ8       251 PWLHAVYAALGAGVFTLFLALDTQLLMGNrr--hsLSPEEYIFGALNIYLDIIYIFTFFLQLFG 312 human
NP_001070536 235 YWLHLLYAGLGTVIFSLYLVMDVQLMVGGrhhhsdLDPEEYVFAALNIYMDIINLFLFILQLIG 298 cattle
NP_083417    239 YWLHLVYSALGTLLFSIYLVMDVQMMVGGryh-yeINPEEYIFAALNIYVDIISLFIFILDLIG 301 house mouse
EEA97072     198 KWAQVLYSSLALLLFSIYLVVDTQLLVGRgk--lrLSEDDYIVAALMIYVDIITIFLQLLRLVA 259 Toxoplasma gondii ME49
NP_001120085 219 MYLNIVYASIGTFIFGMYLVVDTQLIVGGkhr-yaVSPEEYIFAALNIYLDIINLFLMLLQIFG 281 western clawed frog
XP_003222024 276 MWLRIVSGAFGTVLFSVYLLVDTQLMLGKthh-yrLEPNDYIFAVLNVYIDIINTCLFVLKFVG 338 green anole
XP_003249414 227 RLLHILISIIGMTLLSTYLFFDIQTIMGGrr--ieLNPDEVIFATAQIYVDIVLLYQYILMFMA 288 honey bee
EDW32550     239 LTENIVMSSLMAIIACFFLIYDTQQIVGGnhe-yqFSPEEYVFAALTLYVDVVRILVYILRILQ 301 Drosophila persimilis
EEE22290     277 RVANLIYASLASLLFSFLLVYDTQQVVGGkhrkfqYSIDDYIFAALSLYMDIIGLFMNILSLLS 340 Toxoplasma gondii GT1
NP_724626    209 FVDSLPITCLCTFIGCFFLIADMQSIVGGnrs-eqLDPEEYVFAALTLYVDVVRIFIYILRILE 271 fruit fly
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