4F52_E     3 M------------------------------------------------AVEELQSiikrcqILEEQdfKEEDFGLFQLA 34  human
Q7JRC9     1 M-------------------------------------------------QEQEME------VEVGDpaKASNLLRLIKQ 25  fruit fly
Q5U3W2     1 M------------------------------------------------ALDQLSDmvqrcqTVKDEsfSPEDYDLFTAA 32  zebrafish
Q6PCE9     1 M------------------------------------------------AAADLQSitekfqNLSEDdfKEEDTNVFLVT 32  African clawed frog
CAK48534   1 MallpvspsgclflpprvsavpprpaaispagwpslpshsftpsctsdlAMAAEED------PLIQAlpPATDYLTYLTL 74 
Q0CVJ5     1 M--------------------------------------------------AESED------PLVQAlpPATDYLTYLTL 24  Aspergillus terreus...
Q2UAW5     1 M--------------------------------------------------AEEED------PIVQAlpPATDYLTYLTL 24  Aspergillus oryzae
Q7RZR9     1 M------------------------------------------------DSEKAIA------AIKEArpPATDRFTYLTI 26  Neurospora crassa
EDN95705   1 Me-----------------------------------------------PRIDPVV------DIKANapPVGDHLAYLNF 27 
Q76PC4     1 M------------------------------------------------DWKEAIP------GAAKVaiETKDYITYSTL 26  Schizosaccharomyces...

4F52_E    35 GQRCIE----------EGHTDQLLEII-QnEkNKVIIKNMGWNLVGPVVRCLLCKDK---EDSKRKVYFLIFDLLVKLCN 100 human
Q7JRC9    26 LLLek----------aYDGVRMLFQSAqEsEkNTRLLPHIAMDLYHDVCLENISDEVnsqEPELFDCSDELLKLLAKYAP 95  fruit fly
Q5U3W2    33 GSTCIE----------QGDSAQVLSILvD-EkNQNIVRCMGWNLLGPLVKMLLKKE-----DKTLPHCHAILLHLLEVCS 96  zebrafish
Q6PCE9    33 CQKCLE----------EEEVALLLEIIrD-EkNQAIVKNMGWNLIGPITKCILRSSN----NDTSKICLDMIHYLCMLCN 97  African clawed frog
CAK48534  75 LEYql----------tPARLPILHKLL-Q-D--EVLTTNIGWDLVQLLLPMLPQSL-------------DCLHDIARLGN 127
Q0CVJ5    25 LEYql----------tPARLPVLHKLL-Q-D--ETLTTNIGWDLVQMLLPMLPQSS-------------ECLQDIARLGN 77  Aspergillus terreus...
Q2UAW5    25 LEYql----------tPARLPTLHKLL-Q-D--EVLTTNIGWDLVQLLLPMLPQSL-------------ECLQDIARLGN 77  Aspergillus oryzae
Q7RZR9    27 VETnl----------sPAVLPTLNEVL-Q-D--AELTQEIGWDLVYNLV-NLPGSD-------------ECLETIARLGN 78  Neurospora crassa
EDN95705  28 ITKVLIddqpa-vdlrLELLSSLNDVL-Q-D--KERANLIGWDIMPTLL-RVPGSE-------------SCLITIARLAN 88 
Q76PC4    27 LELILEearikdideqRELIKCLHEELkQ-EkNDHITREISWDIIGMVLPYVGKVQNe--AD-------EFVDFLAKNGN 96  Schizosaccharomyces...

4F52_E   101 PKELLLGLLELIEEPSG--------------------------------------------KQISQSILL-----LLQPL 131 human
Q7JRC9    96 LHELMLELMERLEESSS-----------------------------------------------INVFGA-----YLRAL 123 fruit fly
Q5U3W2    97 PKELLVGLLEQVEEADS--------------------------------------------GFIAETITL-----LLKPL 127 zebrafish
Q6PCE9    98 PKEVLLGLLEQIDEAAG--------------------------------------------EQISQVVLL-----LLQPL 128 African clawed frog
CAK48534 128 PREVILRVSDALMQLQPededddsddgtak------------------adeapqdatdggsKNAALPRHIlqfntLVSML 189
Q0CVJ5    78 PREVILRVSDALMQLQPeded----------------------------------------------------------- 98  Aspergillus terreus...
Q2UAW5    78 PREVILRVSEALMQLQPededdddddddeenetaepaaahdtepvdtelkaatdrdaeksnIQNNLPRHVlkfnaLVAML 157 Aspergillus oryzae
Q7RZR9    79 PREVILKVLETLELLSqddgyqsdd----------------------------eseagetnGEKSVPFKQkf-itLVNML 129 Neurospora crassa
EDN95705  89 PREIIIGVVEAMSELDLedvednwde---------------------------epieneegTAVKESNEIdrfclLLSLL 141
Q76PC4    97 PREVFLKCCELLINGGF--------------------------------------------------ESPqqfisLNSAI 126 Schizosaccharomyces...

4F52_E   132 QTVIQKLHNKAYS--IGLALSTLWNQLSLlpvp-yskEQIQMDDYGLcqccKALIEFTKPF------------------- 189 human
Q7JRC9   124 QVVLQRQGRDKPQa-VEWSLNSIFTHLKDlplpeylsEGYDEAQARLieqnEQVEDLLAHYitvglfr-----------e 191 fruit fly
Q5U3W2   128 QTVLLRLGMKKASs-VGMALSTLLSQVSRlpvp-vtaEQEEDDVFGLcrccSALLQFVKPFve----------------- 188 zebrafish
Q6PCE9   129 QEVLLKLGKRKAYs-VGLSLSTIHSRITClpvp-ftkEQTQEDKHGLcqccCAMVQFTKPF------------------- 187 African clawed frog
CAK48534 190 SVLHSRIQTKSPSrfLATSLQAVLEAYTLmpt---neTTYALLEFF-----RDVSPSKRPAppprvpsessv----lrls 257
Q0CVJ5    99 ---------degGrfIATSLQAALEAYTLmpt---seTTMSLLEFF-----RDVSPSKRPApppraasessv----lrvs 157 Aspergillus terreus...
Q2UAW5   158 SILHSRIQTKSPSrfFATSLQAVLEAYTLmpt---neTTLALLEFF-----RDVSPSKRPApppraasessv----lrvs 225 Aspergillus oryzae
Q7RZR9   130 SILHKRIKTKYPSrfLATSLQTIYNTYRPnh-----eMTAAVINLV-----RSLAGNKRPPlptrkssvnvanpdqhgda 199 Neurospora crassa
EDN95705 142 AIIHPRIKTKHPSrfLANSIDTITNAFHPsh-----kAVLAVGKFI-----QTLSGKKRPTlpgrksslsitnfmrhevd 211
Q76PC4   127 LSALHRISTKRPVlfVNNFLISLFSGLANi-------------------------------------------------- 156 Schizosaccharomyces...

4F52_E   190 ------VEEVIDNKENSLENEK--LKDELLKFCFKSLKCPLLta-------------------------qFFEQSEEGGN 236 human
Q7JRC9   192 plrdeiLQQDVRTPSQIFRDCGvnRRNIFTCFFIQLLGRPLA-----------------------------LLEMNHAKE 242 fruit fly
Q5U3W2   189 ----eiKEVVKDNNSISKDNE---LRVELLKFCMKSLSEPLLe--------------------------vQLKDTDTLQR 235 zebrafish
Q6PCE9   188 ------VDVVSQSKALIIEPDTaeLRKELLAFCFSCLKYPLLta-------------------------qLNLFPENTDD 236 African clawed frog
CAK48534 258 eksapdPEAEVQSPSPASDDESvlVQKFLQFGLIEALKSYLLsftgpsdpgmswairlqeklqpglrlakQETPSDAFAN 337
Q0CVJ5   158 easapdPEAESQSTTPADNEEPalVRRFLQFGLIELVKSYLLsfssptdpgmcwairlqeklrpgtrmpgGQSQTEAFSE 237 Aspergillus terreus...
Q2UAW5   226 easapdPEAEVQSPNPS-NNEPalIKRFLQFGLIELIKSYILsfsgpmdpgmswti-rlqeklqtrhltgQVSETEVFAN 303 Aspergillus oryzae
Q7RZR9   200 tknapdPEADKDTEH---PTETaiQERLLLSFATCILESFVNkndvawaprll------efhnpekivpgRKTLMARFRE 270 Neurospora crassa
EDN95705 212 sslptaPDPESEEEE---SYESaiQQKLLQGFAVHILGLYINehpiewagrlq------elfepervvagRTSLCVAFRV 282
Q76PC4   157 ------lQIDSDELYCVWKISIssIQDAMHRFPVSECYLACLkacsilaqlfls-----ketlmlsfrslLQTKDQYAEF 225 Schizosaccharomyces...

4F52_E   237 DPfryfaseIIGFLSAIGHP--FPKMIFNHGRKKrTWNYLEFE-----------------------EEENkqlADsmASL 291 human
Q7JRC9   243 DLtrsyvqqVTESLTQDANQflGDPFYLLNLVEQrARWLRKLDasrgvye---------mscqnvfLIEEklpLHavAMY 313 fruit fly
Q5U3W2   236 SPlrdfateILIILSDIGES--LPDLLSRNVLRRrKVP--GFL-----------------------EEEVrypKEslACM 288 zebrafish
Q6PCE9   237 NPffqfakdILGTFVLLGEP--LSVAFLQHGDRTpILEIEDVR-----------------------PEEGkctAEtfACL 291 African clawed frog
CAK48534 338 HKelkerdmIIAKITAPkdqp-----------------------------------------lpldFEEPprkAD----- 371
Q0CVJ5   238 SKelrerdmIMAKITALS----RDFGLEDkllleivslp------------------senqpppldFDELpkkAD----- 290 Aspergillus terreus...
Q2UAW5   304 NKelserdmILGKITALS----RDFGLDDkqllavvsqp------------------adkhpqpldFDEPprnVE----- 356 Aspergillus oryzae
Q7RZR9   271 EKelsekdgAVGQLVALI----ADLGLSSCDktflsqvte-----------------gtlqtdplsKTEDiakPE----- 324 Neurospora crassa
EDN95705 283 DPglqirdeVTGQIVALC----RDLGLADynllfdtiyatp-------------piarvrsehedpRDNLpdsPE----- 340
Q76PC4   226 REelsgattNCDKLDTLSKS---IINIFDYLLSH-LPESWSIItehmaqeltkatyvsqsssisseDEEIaknADvpAEV 301 Schizosaccharomyces...

4F52_E   292 AYLVFVQGIhIdQLPMVLSPLYLLQFNm--------------------gHIEVFLQRT--------EESVISKGLELLEN 343 human
Q7JRC9   314 YHSLFVGNQlPtNAPKVYAPLFLFETIv--------------------yLAEVLLRQQ--------EPPLQYCGLRLVEH 365 fruit fly
Q5U3W2   289 SHLLFVDHIaVdIFPAVFSPIFVLQCNm--------------------eYIELLLSRT--------EENRLQKGLELYEK 340 zebrafish
Q6PCE9   292 SYLLFVQHIgLdDFPFVFGPTFLLKTNm--------------------qHVDVLLKRT--------EESILSKGLELLEN 343 African clawed frog
CAK48534 372 ------------EIPLERHGSLLLLAAraataelfssg-qvspivifpdLARIFQNFVggynspdeVAFGQPQVLLDSLL 438
Q0CVJ5   291 ------------QIPLERHGALLLLAAraamaelfssg-qvipiavfpdLANIFANFVggyntpddVAFGQPQALLDSLL 357 Aspergillus terreus...
Q2UAW5   357 ------------EIPLERHGALLLLAAraamaelfssg-qvtpiavfpeLAQIFDNFVgahdkpdeIAFGQPQALLDSLL 423 Aspergillus oryzae
Q7RZR9   325 ------------DIGLSTGGCVILLAYwvfsttvfdsdhpvpdmhifpdHLAMLEKFLqdd---aeDQIRKAPGTVQALV 389 Neurospora crassa
EDN95705 341 ------------EIPLSPNGSLFLLTSlvfsslmfktkspepvmsifpdHAKLVARFFd-------SADGSSIAIVDAVV 401
Q76PC4   302 DNNSTKADDkRdEIEFDTKGCLALLTIksfyqsgnff--ldflkekfpsTILETLQQLvs-----wEIQLDSVGFKDIAV 374 Schizosaccharomyces...

4F52_E   344 SLLRIEDNSLL----------YQYL----EIKSFLTVPQGLVKVMTLCPIETLRKKSLAMLQLYINKLDSQG-KYTLFRC 408 human
Q7JRC9   366 HLSTLQ-HSVP----------TSSL----QLDVHKRFCEALCKIVGYSPQVALRQLGIHVLRQFVLAFDDHG-KYLILKN 429 fruit fly
Q5U3W2   341 SLVRVEENSLP----------VDLL----ELKTFFSVPQNLVKVMTMCPDQTLRTKGLKVFQLSIDKFNTEA-KYKFFRG 405 zebrafish
Q6PCE9   344 SLLRVEDESLH----------QDFL----EIKAVLHVVQDLEKVMTLCPIEHLRKRSLKLLQLMIDKFGEEG-KYKLFRC 408 African clawed frog
CAK48534 439 TLTVFSMQKPSd---------tTPH-----EKDFVDFVLTLTACTARQN----YSSVRRIPGTIIRTHPSQVtQFKVIRT 500
Q0CVJ5   358 TLTVFSMQKTIg----------tPA----TEREFQDFILALTACTARQH----FSSVRQIPGIIVHSNPSPTaRFKIIRN 419 Aspergillus terreus...
Q2UAW5   424 TLTVFSMQRSIg----------ePS----TEIEFRRFILSLTACTTRQS----YNSIRRIPGTILHSHPSHIvRFKTIRL 485 Aspergillus oryzae
Q7RZR9   390 TIGLWLHDKGLisaipkaplaNQTTnpdeATSDYMRYILFVTLIAVFHPQLHVRNAASCLAGLVLHADPADDdRLKILYD 469 Neurospora crassa
EDN95705 402 AIGLWLEHSNKf--------vSGEF----KDNDYMAHLRALSLWSATNPSPGLRYCTHKLTSAILHAHPVDAiRLVFISK 469
Q76PC4   375 YQGYLLDLPHFq---------VPDS----ELEHLSSLLHGYHFMASSTELPWLRVTCNAIVTKCLDSQLPSV-RLSYILD 440 Schizosaccharomyces...

4F52_E   409 LLNTSNHS----GVEAFIIQNIKNQIDMSLKRT------------------------------------RNNKWFTGPQL 448 human
Q7JRC9   430 LMGTLQHG----GLMGYLGGMYKDLVDKALGQSg-----------------------------------pMPEVYSGKLF 470 fruit fly
Q5U3W2   406 MLKTSHHA----GVEGYIIKNIKNQIDSSLKPGn------------------------------------SNDWFLGKHL 445 zebrafish
Q6PCE9   409 LFKSSNHA----GVQGYIIQNIKNQIDIALQTNs------------------------------------NSKWFLGPRL 448 African clawed frog
CAK48534 501 VLEDDRFQ----SVKDSAIGWLRTGILEAANSSkag------------------------------tsaEPSVYLDPHYF 546
Q0CVJ5   420 VLEEENYL----TVKDSAIGWLQNEILSAVNESpt---------------------------------aEPSIFLNPHYF 462 Aspergillus terreus...
Q2UAW5   486 VLEDDRFQ----LIRDSAIGWLKDEILDANKKPsg--------------------------------spESDIFINPHYF 529 Aspergillus oryzae
Q7RZR9   470 LLENCDYA----SLKACAVTWLREELIAAAPNAqaapqnlaalnnqaplpspslqpgtatpgtrsragtNMNVFAGPQAL 545 Neurospora crassa
EDN95705 470 TLQGSPDEisaiALKVSAITWLKEELITAHERKs------------------------------------QNLFSTSSVL 513
Q76PC4   441 TLEECPLL----NIKTAILNYYQKQCSLVKDSNeeg----------------------------------lknFVSPNTL 482 Schizosaccharomyces...

4F52_E   449 ISLLDLVLFLPEG-----------AETdllqnSDRIMASLNLLRYLVIkDNendnqt-glwtelGNIENNfLKPLHIGLN 516 human
Q7JRC9   471 REMLLLCVCVLPHd----------VKSdlllhSDRLCHALNILRYFAArDKndvtg---fwqalPEIEKElLDPLGTALN 537 fruit fly
Q5U3W2   446 LPLLRLVLCLPQG-----------PETdllqnLDRIMESLNLLRYMLI-RDkewdnetgiwtelYKIEDNyLKPMRTGLN 513 zebrafish
Q6PCE9   449 TPLLHMVLSLPEG-----------AETdllqySDRIMASLNLLRYLIIrQDnevdtktavwtelGRIENNyLKPLHIGLN 517 African clawed frog
CAK48534 547 SVVFPSLFNSSDLfmnvssdlvasFIKfsqtlSPSIHAALSLYYTIVSsPHlrkqlq--lektyVYFRNRfLEPLKSLCH 624
Q0CVJ5   463 SVLFPSLFNPAQLllnvssdivasWIKfsqslVPSIHAALNLYYILVSsADlrsrlq--lgktyLFFRNRfLEPLKTLLH 540 Aspergillus terreus...
Q2UAW5   530 SILFPLLFNSSELllnvssdivasWIKfsqtlTPSIHAALSLYYILLSsSTlraqlq--lektyIYFRNRfLEPLKSLLH 607 Aspergillus oryzae
Q7RZR9   546 ETVQYVVFPNMGFlkel---dlqkLVNelgtnAPFFLQAVNFGLFLWSsADkwrrvl--ppnldATVKERwFAPLHDAVA 620 Neurospora crassa
EDN95705 514 LETKSQIFPNLSIlvdd---sdeeLTNdlmasFAVHMAALNFLFFITAeqyani----ippgmmTQVESEyIVPLKTAQE 586
Q76PC4   483 LDVFKVFDAME-------------DVEldsqsLSYIHQTLVFLYSLEIqNLls----------qNQFPTVyFTKISDQIN 539 Schizosaccharomyces...