Conserved Protein Domain Family
PTPLA
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pfam04387: PTPLA 
Protein tyrosine phosphatase-like protein, PTPLA
This family includes the mammalian protein tyrosine phosphatase-like protein, PTPLA. A significant variation of PTPLA from other protein tyrosine phosphatases is the presence of proline instead of catalytic arginine at the active site. It is thought that PTPLA proteins have a role in the development, differentiation, and maintenance of a number of tissue types.
Links
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Statistics
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PSSM-Id: 461286
Aligned: 213 rows
Threshold Bit Score: 124.168
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CCA76030     220 QSLALLEVVHSALGLVKSPVQTTAMQVASRLAVVWWFVEGQPTARItPFYTTMLIAWSLSEMIRTTYYTASLFNvvpprp 299
KRH29854      52 QCAAFLEVIHGAIGIVPSGVLLPLMQWGGRTHFVLAIVRKLDELQElPSVFITFLAWSMGEVIRYSHYAFGCLGn----- 126
XP_002298376  52 QTVSFLEVIHGALGVVPSGVLFPFMQWGGRTHFVLAIVRQIIEVQElPSVFITFVAWSMAEVIRYSHYALNCVGs----- 126
XP_002531119  53 QILAFLEVIHGALGLVPSGVLFPFMQWGGRTHFVF-IVRNLIEVQElPSVFITFFVWSLSEVIRYPHYALNILGn----- 126
XP_002866347  52 QTVAVLEVLHGAIGIVPSGFLSPLMQWSGRTHFILAIVGQIKEVQDsPWLSLTLVAWCIGEMIRYPHYAFTCLGs----- 126
EFN59260      54 QLASALEILHAAVGLVGGSPVTALMQWAGRSNVLFGVVGAVPEVQNtAAVGAMLLAWALSEVTRYPWYAANLVGa----- 128
Q018N9        50 QIASFAEVLHALIGLTRTPAAAALMQWAGRTHCLLCALDGVRSNHSsDAATVLVFAWAITEVIRYPAYVCGLLGi----- 124 Ostreococcus tauri
XP_001418068  50 QLASFAEIAHAVAGLTPTPAAAALAQWSGRTHCLKCALDAVKTSHAsVAATALVFAWALTEVVRYPSYVGGLIGr----- 124
XP_002502560  51 QVASVLEVFHAGLKLTRTPMSAALMQWAGRTHVLIAVTHAIPHLQTtAAAGILILAWALTEVIRYPSYALS-QS------ 123
EFJ47290      51 QGASLLETLHAAVGLVPSSPLMSLMQWMGRSNVFFLILEPNPQVRMsWWSVLMMGTWAAAEVIRYPQYMLSTALge---- 126

CCA76030     300 ttnPYvakavDILTNIRYSAFYVLYPLGSG-SEYMCMLKGFPSFpskaaaltskegwkaiisrnppawrvlfervklwiy 378
KRH29854     127 ---CP-----SWMTYLRYTAFIVLYPLGVGpGEIWAMYQALPVIkeknlya-----------------------dsfssl 175
XP_002298376 127 ---CP-----SWITYLRYTAFIVLYPIGLApGEMWTMYQALPFVkkknlya-----------------------dffaaf 175
XP_002531119 127 ---CP-----SWINYLRYTAFIVLYPIGIApGEMWLIYQALPFVkktslfa-----------------------nffaal 175
XP_002866347 127 ---CP-----YWLTYLRYTGFIIIYPTGLV-GELLIMYKALPYVketnlyv-----------------------kffsvf 174
EFN59260     129 ---CP-----RWLTWIRYTAFIPLYPVGVV-GEMWSVYQALPFIkqrglrsvp--------------------lpnaanf 179
Q018N9       125 ---ES-----KALTWARYTVFVPLYPLGAG-AEMKLMYDARAHArrtkmyaie--------------------mpnaynf 175 Ostreococcus tauri
XP_001418068 125 ---SP-----KWLTWSRYTVFVPLYPLGAA-AEMKLMYDARAHArktkmyavt--------------------mpnaynf 175
XP_002502560 124 ---CP-----GWLNWLRYTIFIPLYPIGAA-SEMKLMYDGIPTMtakkmysis--------------------mpnaynf 174
EFJ47290     127 --rCP-----HWLTWLRYTMFIPLYPVGVV-AEMGLMVAALPYLaaskpysle--------------------lpnaynw 178

CCA76030     379 nWDAAAWTRVpFVFIWPAGLYILMSYMHVQRRKALGR 415
KRH29854     176 pFSYYDFLKV-VLIAYPFLWFKLYLHMFKQRRTKLYK 211
XP_002298376 176 pFSYYDFLRV-VLLCYPFLWLNLYRYLLKQRRSKLGR 211
XP_002531119 176 pLNYHDFLRV-GLVCYPFLWFNLYLHLLKQRRLKLGK 211
XP_002866347 175 pFSYYDFLWD-VLLVYPFLWLKLYLQLFKQRKSKLGK 210
EFN59260     180 aFDYPTFLVA-LMCVYPLLWFQLYSFLFRQRRKKLQP 215
Q018N9       176 aFDYPTFLNA-LLVLYPFLFHGLYSYMFAQRRKKLGG 211 Ostreococcus tauri
XP_001418068 176 aFDYVTFLNA-LLVAYPFLFYTLYRYMFAQRRKKLGK 211
XP_002502560 175 aFDYTSFVKV-VLILYPFLFYQLYAYMFVQRKKKLGP 210
EFJ47290     179 aFSYHRFIQI-VLALYPFLWWQLYSALLRSRSKKLTQ 214
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