3S55,3T7C


Conserved Protein Domain Family
SDR_subfam_1

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TIGR03971: SDR_subfam_1 
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SDR family mycofactocin-dependent oxidoreductase
Members of this protein subfamily are putative oxidoreductases belonging to the larger SDR family. All members occur in genomes that encode a cassette for the biosynthesis of mycofactocin, a proposed electron carrier of a novel redox pool. Characterized members of this family are described as NDMA-dependent, meaning that a blue aniline dye serving as an artificial electron acceptor is required for members of this family to cycle in vitro, since the bound NAD residue is not exchangeable. See EC 1.1.99.36. [Unknown function, Enzymes of unknown specificity]
Statistics
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PSSM-Id: 274889
Aligned: 98 rows
Threshold Bit Score: 313.254
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3S55_A         8 FEGKTALITGGARGMGRSHAVALAEAGADIAICDRCENSDVVGYPLATADDLAETVALVEKTGRRCISAKVDVKDRAALE 87  Mycobacterium a...
ZP_08120409    4 LDGKVAVITGGGRGQGRAHAIRLAREGADIVTCDITEQVGSVPFDTGRPGDLDETVAQVEKLGRRCVALEGDVRRTADMA 83  Pseudonocardia ...
ZP_08120406    4 MTGKVALVTGAARGQGRAHAVTLAAEGADVVAVDVPGEIGTAQYPMGSADELAETVRLVQAHGRRALAVRADLRDTVAVE 83  Pseudonocardia ...
ZP_08121068    4 LEGKVALITGAARGQGRSHALAMAREGAEIVAVDICDEIGSVPYGLATPDDLKETVEQVEALDRRIIGRKVDARDQAQLD 83  Pseudonocardia ...
WP_011603614  12 LEGKVALITGGARGQGRAHAVTCAREGADVVIVDITEQLSTVAYKMAVQADVDETVAQVEALGRRALAIEADVRSQSELD 91  Frankia alni
WP_012944949   6 FSGQVAFVTGAARGQGRSHAKLYAEHGADVVIVDVCDSMDSIPYNLGTRDELDSVVEAVEDRGQDALALECDVSNEADVE 85  Haloterrigena t...
WP_013674373   4 LDGKVALITGAGRGQGRSHALTLAREGADIIAVDVPGSVESIEYELSGSDDLAETVKGVEELDRRIIAVEGDARSQEALD 83  Pseudonocardia ...
WP_011600063   4 MDGKVALVTGAARGMGRAHAIRLAEEGANILAID-CPPDTGLPYPTGSSDDLQITVKEVEALGRRIIAHEGDVRKQSSLD 82  Rhodococcus jostii
WP_012944953   6 FDGEVAFVTGAARGQGRSHAVAYAEHGADVVVADLAGQSGAAQYPLATEADLAETVSRVEATGQRALPVRMDVRDERDVE 85  Haloterrigena t...
WP_012873313   6 LEGKVALVTGAARGQGREHCLALARAGAAIAALDICRDLEVPTYPLGTRAELDAVVAAVEDLDRPALGLVADVRSADEVA 85  Sphaerobacter t...
3S55_A        88 SFVAEAEDTLGGIDIAITNAGIS-TIALLPEVESaqWDEVIGTNLTGTFNTIAAVAPGMikr-nyGRIVTVSSMLGHSAN 165 Mycobacterium a...
ZP_08120409   84 RLADAAMSEFGRIDVLLANAGILsLSDNTWELTDeaWDDMIDINLTGVFKACRAVVPHIraggdgGSIVITSSIAGLRGV 163 Pseudonocardia ...
ZP_08120406   84 AMAQQAMTEFGRIDALVCNAGFMsAAENTWSLTDaqWADMLDVNLTSVWKTTRAVVPHMiaggngGAITITGSTGGLRAV 163 Pseudonocardia ...
ZP_08121068   84 GVVAEAISEFGGIDIVAINHGIW-TRGPLWELSEqtWQDTVDTNLTAVWKTLKAVAPHLidr-rrGSIVITSSVNGVEAQ 161 Pseudonocardia ...
WP_011603614  92 DAVAQGIAEFGKIDILIANAGIW-TQAPFWKLTEdqWDQMIGVNLTGVWKSAKAVTPHMier-rsGSIVITSSVNGLEPG 169 Frankia alni
WP_012944949  86 EAVDQAIEEFGRIDFLANNAGIF-TLSEAVEMSEaeWDRVLDTNLKGVWLCAKHVGKHMiergdgGKIINTSSGYGLVGG 164 Haloterrigena t...
WP_013674373  84 GAVAAGLSEFGQIDILVANHGVL-SIENFWEMSEerWTQMIDINLSGMWRAAKAVAPHMier-grGAICMTASINAIETG 161 Pseudonocardia ...
WP_011600063  83 KLVADGVKAFGGLDVAVANAGIW-TVHPFHDIPEdeFTAVLDVNITGVWRTLKAVSPAIter-ggGSIIVTSSGNGVEGS 160 Rhodococcus jostii
WP_012944953  86 AAVDEALTEYGKIDILANNAGIW-HVADLVELEAehWEKTLATDLKGAWLCAKHVGTHFadrgdgGRIVSTASTAALVGT 164 Haloterrigena t...
WP_012873313  86 AAVAETVATFGRLDIVVNNAAIA-GSGPFWELTEeqWDAVVDTDLKSVWLVSKYAAPHLlkr-pgGRIVNISSTAGARGL 163 Sphaerobacter t...
3S55_A       166 FAQASYVSSKWGVIGLTKCAAHDLVGYGITVNAVAPGNIETPMThNDFVFG-TMR---PDL-----EKptlkdvESVFas 236 Mycobacterium a...
ZP_08120409  164 AGCTHYTAAKHGIVGLMRTLAKELAPESIRVNTIHPTGVASPMSnNDFFPQ-WLT---EHE-----EL------GNAMr- 227 Pseudonocardia ...
ZP_08120406  164 AGCTHYNAAKYGCIALMKTLAWELAPDNIRVNVVHPTGVDTDMSnNDWFVR-WLG---EHE-----DL------AEPMr- 227 Pseudonocardia ...
ZP_08121068  162 AGSAHYTASKHGAIGLMKSAAMEFAPHGVRVNAIMPGFVDTNMTnWQGAWD-MTS---GHPggtreEH------EVAArh 231 Pseudonocardia ...
WP_011603614 170 QNYAHYVSAKHGVIGLMKNIALELARYGIRCNSINPGAILTPMTdHQAAWD-MFA---GHP-----GGtea-dmIEGGyh 239 Frankia alni
WP_012944949 165 LLEGHYTASKHGVNGLTKTLALELAEYDINVNAVAPTGVDTPMM--EEFVE-VYG---D-------EIld--evVELTgp 229 Haloterrigena t...
WP_013674373 162 PGYTHYNVSKAGVVMLMKNVALELGGYGIRCNAICPGAANTKIVdWQGLYDnLIF---PGA-----GHsd---lWDATrn 230 Pseudonocardia ...
WP_011600063 161 PHYAHYVASKHGVIGLAKSAALEFGQYGIRVNILLPGPTDTPALdWQGGYD-LCAgkgPGQ-----GVke---dlEGAky 231 Rhodococcus jostii
WP_012944953 165 RGSGHYAAAKHGLVGLTKSLALELAEYDVTVNAVAPTGVATPLI--DGILE-SIG---E-------AAls--rvSDASgs 229 Haloterrigena t...
WP_012873313 164 AHFAHYSAAKHGVIGLTRSMAVELAPYGVTVNAILPGAVASPMLd-----G-LAE---ELG-----VTpa--diHRVFlh 227 Sphaerobacter t...
3S55_A       237 LHLQ-YAPFLKPEEVTRAVLFLVDEASSHITGTVLPIDAGATAR 279 Mycobacterium abscessus ATCC 19977
ZP_08120409  228 FNLM-PVDALPEADVSEVIAFLCSDAGKWITGTTVPVDAGFMLK 270 Pseudonocardia sp. P1
ZP_08120406  228 GNRM-PAEVVQPEDVSKMVAFLVSDDARYVTGVEHRVDAGFMIK 270 Pseudonocardia sp. P1
ZP_08121068  232 WHAF-G-GLMRPEDISGAVVFLASDESSRITGIEMPVDSGHLVL 273 Pseudonocardia sp. P1
WP_011603614 240 YGALkGTTFLDPQAIADTALYLNSDLAANVTGVTIPVDAGHLLi 283 Frankia alni
WP_012944949 230 WNIF-GGGMIESRDISEAYMWLSSDASRYVTGITLPVDAGLSAK 272 Haloterrigena turkmenica
WP_013674373 231 WTALkDRRLLDPQTLSNGVLFLVSDDAKDITGVALPIDAGHLIl 274 Pseudonocardia dioxanivorans
WP_011600063 232 WSALrDVGLLPPRAMSEAVLWLASDESRWTTGLEMHVDGGHMLM 275 Rhodococcus jostii
WP_012944953 230 MNVL-DEQFVDPRDVSEAFLWLSSDAARCVTGAVLPVDAGMTAK 272 Haloterrigena turkmenica
WP_012873313 228 HQLF--EEVLEPREITEALLWLVSDSARHITGHCLAVDGGWLVK 269 Sphaerobacter thermophilus
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