Conserved Protein Domain Family
Casc1_N

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pfam15927: Casc1_N 
Cancer susceptibility candidate 1 N-terminus
This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 200 amino acids in length. The family is found in association with pfam12366. There are two completely conserved residues (N and W) that may be functionally important.
Statistics
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PSSM-Id: 464947
Aligned: 30 rows
Threshold Bit Score: 124.01
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFJ46480       28 EAARLA--EEERLRAEEaERQRLAELERQRLELLEQFlAAERARLDVELDELGPLFRQFEHERVRSRNEALEAAEWERFL 105 
CBN79221       29 AEILRAkrEAERIRKEA-EDAKRLKEEQIADR------TEELERLSNELQEAQDQIAETKERLRWAEKLEAVQSSWETYT 101 
XP_004995304   21 ERLQRE--EEERLQKEA-EEALKEQKRLRDKLLRD-----QADRFKDEVVLVKDKYMLLQQALERLHEEEEDAKQWRRIV 92  
EFN79247       30 IIKDMH--EEIRQEKYN-AERQVLLDEK------------ETAMRKVQLEKTWHALQDHESAFMEYVADAEKEKNWSRYM 94  
XP_003423865  140 LIKELQ--DEIELDTYN-NEQNAQIEEE------------RMRQRRAQLEKTWHRVHERRKAFVDYALKCFEEDEWLRYM 204 
XP_015837770  509 EAARAA--ELERIRLEE-ERKAAIEKEKRE--------TFEQQIRMEQLEVALQYINDVVRYNKKLRHDAKVQEDWEFYV 577 
1_pfamImport    1 AKQEAE--ELSRMRLARlIEIKNLQEDAKLREKRS---INEHSIRLYILEKNVRLFESVKKKFLDDRINMRQEDEWRQYL 75  
EFC50681       74 ERIRKEeeEERKRKEEE-ERKINEERRKKAEEEKKRL-DEEKGSFDSEV------IPSFKEKLHTLMIVAKEEDEWNKFV 145 
XP_001315841   68 KRLKLEqlERERQQQLA-EKANREAEERRKREREMA--LAGQQRLQNEETQLKEFREARILNNATIRADAAKQTDWETYL 144 
XP_001580967   47 ARLKREkaEQERLEQEKlEAAKKAQQEKEEESRKR---AEQQQRLEEEKEYIKNFRLQKEEKIQKIVANFEKTEDWELFS 123 
EFJ46480      106 RCVRVPAPRQRVEVNEFLLRMNESSRee-------dsRSLEEAFLTCedcrTMVLETRQALletrnrvVgsGGPEEEASR 178 
CBN79221      102 KCDPRPDAASEKALNTFLSQGADEEV-----------PELDQAMERCvygeSIAADLLNDI----------GQSLENGDI 160 
XP_004995304   93 ECHDTPALTDTRAVNTYLSQWLNESMrvdlnpaeeahVDIKKRMQEI----TQAYKLAAEA-----------DAQATLAE 157 
EFN79247       95 TCDGLPNPGSLSDMNTFLFLWSMEDKe----------VNMSNFTKKY----DTIIYLITKLde-------ivRFSLMRPP 153 
XP_003423865  205 SCDGLPDPAVLPELNTFLFLWSLDDSk----------ASMKSLPRQC----EIVIYLIRKLde-------iiEFSPQSEP 263 
XP_015837770  578 NCGRLPNPAKCDQMNTFLHLWENVIEq----------TTMEEAAKRT----VDMLELLNELdd-------liDTAEETDQ 636 
1_pfamImport   76 CCDRLPLPSDPSSMNTHLYYWSSLKEa----------EFMDNILEWI----EKYIALLSDLer-------liEEPLDATP 134 
EFC50681      146 NCENLPKLDDDVDMNNFISSWRDLNElalkkeirninEDFAMVVEGC--------KVMNEIey---llV--E-SIAQSKK 211 
XP_001315841  145 QCDHSTNPLDKADVNSFITLWREAED-----------TNMPVLFEHI----ATVVKLINQLtnl------ryTAEVAAIN 203 
XP_001580967  124 QCSHAIDVRSEADVNTFISQLSEVNE-----------TDINQLFEHI----HLAKVIENQLrer------seKAQLANRV 182 
EFJ46480      179 KALE---SDIR-----ELYAIINARIDRFTAAVLHHCDEYANERNEIQLGHVAGT-----FKWGVWVNTA-----KNPR 239 
CBN79221      161 SRMArneEFLE-----LLRGLSFDKIDFATAHLLSHWDSLSGGDEDFDRTCMTAGg----IRVGVWVNVSl----KGFR 226 
XP_004995304  158 ARGDeeeEVVLlrtnkVLRDASMTKLTNMITKLLQFPDMNTREFEEDLYVCEQPSttdceAALFLWANLA-----RNPa 231 
EFN79247      154 DYLFeckTIRQ-----RFRDKLQKWIDMACYALLRQIERDMVREDIKTTRYSNVSr---hVSCCIWALIKwpiklKQPs 224 
XP_003423865  264 TYIQdckQIRQ-----KFREKLQGWIDMASYCLLRQIERDTIRVDLKNARYVQQLt---pLVCCFWALIRmpislkqva 334 
XP_015837770  637 SVIDnwkWVRL-----LFRQQQAKSLDVATYRLLRDIERNLHRIDIPTADYKYQDd---nIVLCLWLRVQlptplPNPR 707 
1_pfamImport  135 TKVEnwkEVRE-----SYRSEIFKKFDQGTFHILRKIETKMNRIDYWTVDYKRITk---nVKICMWAWL---------- 195 
EFC50681      212 DLEThctKYLN-----YLSNCIVQTMDDATAHIMQYFDKYLSSENDQYQKVHPF------IKYGIWTNIS-----KNLY 274 
XP_001315841  204 EDVTrfsEHIN-----DIRSIISQKIELLTQHHLMFSDKYTGAKSEVLLNAESSG-----YQYGLWVNLA-----KNPR 267 
XP_001580967  183 PLYTrcnRQID-----TLQQLINQKIENITVNHLAFSDKFSGAKGDVQINGGSDD-----ITYGMWVNLS-----KNPR 246 
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