7O7Y,7NH7


Conserved Protein Domain Family
CoV_NSP10
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pfam09401: CoV_NSP10 
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Coronavirus RNA synthesis protein NSP10
Non-structural protein 10 (NSP10) is involved in RNA synthesis. It is synthesized as a polyprotein whose cleavage generates many non-structural proteins. NSP10 contains two zinc binding motifs and forms two anti-parallel helices which are stacked against an irregular beta sheet. A cluster of basic residues on the protein surface suggests a nucleic acid-binding function. NSP10 interacts with NSP14 and NSP16 and regulates their respective ExoN and 2-O-MTase activities. When binding to the N-terminal of NSP14, nsp10 allows the ExoN active site to adopt a stably closed conformation and is an allosteric regulator that stabilizes NSP16. The residue Tyr-96 plays a crucial role in the NSP10-NSP16/NSP14 interaction. This residue is specific for SARS-CoV NSP10 and is a phenylalanine in most other Coronavirus homologs.
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Statistics
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PSSM-Id: 462788
Aligned: 8 rows
Threshold Bit Score: 214.996
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7O7Y_BK        12 TVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHP----NPK 87  
P0C6V0       4329 AILSLCAFSVDPKKTYLDYIKQGGVPVTNCVKMLCDHAGTGMAITIKPEATTNQDSYGGASVCIYCRSRVEHP----DVD 4404 Murine hepati...
Q98VG9       3900 GLLTLCAFAPDPAKAYVDAVKRGMQPVTNCVKMLSNGAGNGMAITNGVESNTQQDSYGGASVCIYCRCHVEHP----AID 3975 Feline infect...
P0C6U2       3945 HLLTHCSFAVDPAAAYLDAVKQGAKPVGNCVKMLTNGSGSGQAITCTIDSNTTQDTYGGASVCIYCRAHVAHP----TMD 4020 Human coronav...
P0C6U8       4242 TVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHP----NPK 4317 Severe acute ...
YP_002308496 3478 SLLTYLAFAVNPKEAYLKHLADGGNPIRGCIQMIAS-LGPGFAVTTKPQPNEHQYSYGGASICLYCRAHIPHP----GAD 3552
P0C6V3       3796 GILSLCSFAVDPADTYCKYVAAGNQPLGNCVKMLTVHNGSGFAITSKPSPTPDQDSYGGASVCLYCRAHIAHPgsvgNLD 3875 Avian infecti...
7NH7_B          3 SILSLCAFSVDPKKTYLDFIQQGGTPIANCVKMLCDHAGTGMAITVKPDATTSQDSYGGASVCIYCRARVEHP----DVD 78  

7O7Y_BK        88 GFCDLKGKYVQIPTTcANDPVGFTLKNTVCTVCGMWKGYGCSCD 131 
P0C6V0       4405 GLCKLRGKFVQVPLG-IKDPVSYVLTHDVCQVCGFWRDGSCSCV 4447 Murine hepatitis virus strain A59
Q98VG9       3976 GLCRFKGKFVQVPTG-TQDPIRFCIENEVCVVCGCWLTNGCMCD 4018 Feline infectious peritonitis virus (strain 79-1146)
P0C6U2       4021 GFCQYKGKWVQVPIG-TNDPIRFCLENTVCKVCGCWLNHGCTCD 4063 Human coronavirus 229E
P0C6U8       4318 GFCDLKGKYVQIPTTcANDPVGFTLRNTVCTVCGMWKGYGCSCD 4361 Severe acute respiratory syndrome-related coronav...
YP_002308496 3553 GRCLYKGRFVQIDKD--KEPISFALTHEPCNACQHWVNYDCTCG 3594
P0C6V3       3876 GRCQFKGSFVQIPTT-EKDPVGFCLRNKVCTVCQCWIGYGCQCD 3918 Avian infectious bronchitis virus (strain Beaudette)
7NH7_B         79 GLCKLRGKFVQVPVG-IKDPVSYVLTHDVCRVCGFWRDGSCSCV 121
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