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Modern Genetic Analysis
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Modern Genetic Analysis
Anthony J F
Griffiths
,
1
William M
Gelbart
,
2
Jeffrey H
Miller
,
3
and
Richard C.
Lewontin
2
1
University of British Columbia
2
Harvard University
3
University of California, Los Angeles
W. H. Freeman
0-7167-3118-5
1999
© 1999
W. H. Freeman and Company
genetics
molecular biology
Table of Contents
Book Information
Preface
Supplements
Acknowledgments
Chapter 1 Genetics and the Organism
Introduction
Genetics and Human Affairs
Genetics and Biology
Genetics begins with Variation
Experimental Genetics
Summary
Concept Map
General Questions
Chapter 2 The Structure of Genes and Genomes
Introduction
The Nature of DNA
The Nature of Genes
The Nature of Genomes
The Nature of Eukaryotic Nuclear Chromosomes
Summary
Concept Map
Solved Problem
Solved Problem
Problems
Chapter 3 Gene Function
Introduction
Genes and RNA
Making Functional Transcripts
Protein Structure
Translation
Protein Function and Malfunction in Cells
Defective Proteins and Dominance And Recessiveness
Functional Division of Labor in the Gene Set
Summary
Concept Map
Solved Problem
Solved Problem
Problems
Chapter 4 The Inheritance of Genes
DNA Replication
Cell Division
Inheritance Patterns of Individual Genes
Human Pedigree Analysis
Inheritance of Organelle Genes
Summary
Concept Map
Solved Problem
Solved Problem
Problems
Chapter 5 Recombination of Genes
Introduction
Independent Assortment
Crossing-Over
Linkage Maps
Mitotic Crossing-Over
The Mechanism of Crossing-Over
Recombination within a Gene
Summary
Concept Map
Solved Problem
Solved Problem
Problems
Chapter 6 Gene Interaction
From Genes to Phenotypes
A Diagnostic Test for Alleles
Interactions Between the Alleles of One Gene
Gene Interaction Leads to Modified Dihybrid Ratios
Penetrance and Expressivity
Summary
Concept Map
Solved Problem
Solved Problem
Problems
Chapter 7 Gene Mutations
Introduction
The Molecular Basis of Mutation
Mutational Analysis
Summary
Concept Map
Solved Problem
Solved Problem
Solved Problem
Solved Problem
Problems
Chapter 8 Chromosome Mutations
Introduction
Changes in Chromosome Number
Chromosomal Rearrangements
The Overall Incidence of Human Chromosome Mutations
Evolution of the Genome
Summary
Concept Map
Solved Problem
Solved Problem
Problems
Chapter 9 The Genetics of Bacteria and Phages
Introduction
Working with Microorganisms
Bacterial Conjugation
Bacterial Transformation
Bacteriophage Genetics
Transduction
Bacterial Gene Transfer in Review
Summary
Concept Map
Solved Problem
Solved Problem
Solved Problem
Problems
Chapter 10 Recombinant DNA Technology
Introduction
Making Recombinant DNA
Cloning a Specific Gene
Using Cloned DNA
Summary
Concept Map
Solved Problem
Solved Problem
Solved Problem
Problems
Chapter 11 Applications of Recombinant DNA Technology
Introduction
In Vitro Mutagenesis
RFLP Mapping
Reverse Genetics
Expressing Eukaryotic Genes in Bacteria
Recombinant DNA Technology in Eukaryotes
Gene Therapy
Using Recombinant DNA to Detect Disease Alleles Directly
Summary
Concept Map
Solved Problem
Solved Problem
Problems
Chapter 12 Genomics
Introduction
Structural Genomics
Functional Genomics
Summary
Concept Map
Solved Problem
Solved Problem
Problems
Chapter 13 Transposable Genetic Elements
Introduction
Insertion Sequences
Transposons
Mechanism of Transposition
Rearrangements Mediated by Transposable Elements
Review of Transposable Elements in Prokaryotes
Ty Elements in Yeast
Transposable Elements in
Drosophila
Retroviruses
Transposition through an RNA Intermediate
Controlling Elements in Maize
Review of Transposable Elements in Eukaryotes
Summary
Concept Map
Solved Problem
Problems
Chapter 14 Regulation of Gene Transcription
Introduction
The Logic of Prokaryotic Gene Regulation
The Basics of Prokaryotic Transcriptional Regulation
Regulation of the Lactose System
Dual Positive And Negative Control: the Arabinose Operon
Metabolic Pathways
Transcription: Gene Regulation in Eukaryotes— an Overview
Regulation of Transcription Factors
Epigenetic Inheritance
Summary
Concept Map
Solved Problems
Problems
Chapter 15 Regulation of Cell Number: Normal and Cancer Cells
Introduction
Cancer and the Control of Cell Number: an Overview
The Cell Proliferation Machinery
The Machinery or Programmed Cell Death
Controlling the Cell Proliferation and Death Machinery
Cancer: the Genetics of Aberrant Cell Control
Summary
Concept Map
Solved Problem
Problems
Chapter 16 The Genetic Basis of Development
Introduction
Central Themes of Developmental Genetics
Binary Fate Decisions: Pathways of Sex Determination
Drosophila Sex Determination: Every Cell for Itself
Sex Determination in Mammals: Coordinated Control by the Endocrine System
Binary Fate Decisions: the Germ Line Versus the Soma
Forming Complex Pattern: Establishing Positional Information
Forming Complex Pattern: Utilizing Positional Information to Establish Cell Fates
Additional Aspects of Pattern Formation
The Many Parallels in Vertebrate and Insect Pattern Formation
Summary
Concept Map
Solved Problem
Solved Problem
Solved Problem
Problems
Chapter 17 Population and Evolutionary Genetics
Darwin’s Revolution
Variation and its Modulation
The Effect of Sexual Reproduction on Variation
The Sources of Variation
Selection
Balanced Polymorphism
Multiple Adaptive Peaks
Artificial Selection
Random Events
A Synthesis of Forces
Summary
Concept Map
Solved Problem
Solved Problem
Solved Problem
Solved Problem
Problems
Chapter 18 Quantitative Genetics
Introduction
Some Basic Statistical Notions
Genotypes and Phenotypic Distribution
Norm of Reaction and Phenotypic Distribution
Determining Norms of Reaction
The Heritability of a Trait
Quantifying Heritability
Locating the Genes
More on Analyzing Variance
Summary
Concept Map
Statistical Appendix to Chapter 18
Measures of Central Tendency
Measures of Dispersion: The Variance
Measures of Relationship
Covariance and correlation
Solved Problem
Solved Problem
Solved Problem
Problems
Glossary
Further Readings
Copyright © 1999
W. H. Freeman and Company
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