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Molecular Biology of the Cell
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Molecular Biology of the Cell
4th ed.
Bruce
Alberts
,
Alexander
Johnson
,
Julian
Lewis
,
Martin
Raff
,
Keith
Roberts
, and
Peter
Walter
Garland Science
0-8153-4072-9
2002
© 2002
Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, and James D. Watson
cell biology
developmental biology
molecular biology
Table of Contents
Book Information
Acknowledgments
Preface
A Note to the Reader
Part I Introduction to the Cell
Chapter 1 Cells and Genomes
The Universal Features of Cells on Earth
The Diversity of Genomes and the Tree of Life
Genetic Information in Eucaryotes
References
Chapter 2 Cell Chemistry and Biosynthesis
The Chemical Components of a Cell
Catalysis and the Use of Energy by Cells
How Cells Obtain Energy from Food
References
Chapter 3 Proteins
The Shape and Structure of Proteins
Protein Function
References
Part II Basic Genetic Mechanisms
Chapter 4 DNA and Chromosomes
The Structure and Function of DNA
Chromosomal DNA and Its Packaging in the Chromatin Fiber
The Global Structure of Chromosomes
References
Chapter 5 DNA Replication, Repair, and Recombination
The Maintenance of DNA Sequences
DNA Replication Mechanisms
The Initiation and Completion of DNA Replication in Chromosomes
DNA Repair
General Recombination
Site-Specific Recombination
References
Chapter 6 How Cells Read the Genome: From DNA to Protein
From DNA to RNA
From RNA to Protein
The RNA World and the Origins of Life
References
Chapter 7 Control of Gene Expression
An Overview of Gene Control
DNA-Binding Motifs in Gene Regulatory Proteins
How Genetic Switches Work
The Molecular Genetic Mechanisms That Create Specialized Cell Types
Posttranscriptional Controls
How Genomes Evolve
References
Part III Methods
Chapter 8 Manipulating Proteins, DNA, and RNA
Isolating Cells and Growing Them in Culture
Fractionation of Cells
Isolating, Cloning, and Sequencing DNA
Analyzing Protein Structure and Function
Studying Gene Expression and Function
References
Chapter 9 Visualizing Cells
Looking at the Structure of Cells in the Microscope
Visualizing Molecules in Living Cells
References
Part IV Internal Organization of the Cell
Chapter 10 Membrane Structure
The Lipid Bilayer
Membrane Proteins
References
Chapter 11 Membrane Transport of Small Molecules and the Electrical Properties of Membranes
Principles of Membrane Transport
Carrier Proteins and Active Membrane Transport
Ion Channels and the Electrical Properties of Membranes
References
Chapter 12 Intracellular Compartments and Protein Sorting
The Compartmentalization of Cells
The Transport of Molecules between the Nucleus and the Cytosol
The Transport of Proteins into Mitochondria and Chloroplasts
Peroxisomes
The Endoplasmic Reticulum
References
Chapter 13 Intracellular Vesicular Traffic
The Molecular Mechanisms of Membrane Transport and the Maintenance of Compartmental Diversity
Transport from the ER through the Golgi Apparatus
Transport from the
Trans
Golgi Network to Lysosomes
Transport into the Cell from the Plasma Membrane: Endocytosis
Transport from the
Trans
Golgi Network to the Cell Exterior: Exocytosis
References
Chapter 14 Energy Conversion: Mitochondria and Chloroplasts
The Mitochondrion
Electron-Transport Chains and Their Proton Pumps
Chloroplasts and Photosynthesis
The Genetic Systems of Mitochondria and Plastids
The Evolution of Electron-Transport Chains
References
Chapter 15 Cell Communication
General Principles of Cell Communication
Signaling through G-Protein-Linked Cell-Surface Receptors
Signaling through Enzyme-Linked Cell-Surface Receptors
Signaling Pathways That Depend on Regulated Proteolysis
Signaling in Plants
References
Chapter 16 The Cytoskeleton
The Self-Assembly and Dynamic Structure of Cytoskeletal Filaments
How Cells Regulate Their Cytoskeletal Filaments
Molecular Motors
The Cytoskeleton and Cell Behavior
References
Chapter 17 The Cell Cycle and Programmed Cell Death
An Overview of the Cell Cycle
Components of the Cell-Cycle Control System
Intracellular Control of Cell-Cycle Events
Programmed Cell Death (Apoptosis)
Extracellular Control of Cell Division, Cell Growth, and Apoptosis
References
Chapter 18 The Mechanics of Cell Division
An Overview of M Phase
Mitosis
Cytokinesis
References
Part V Cells in Their Social Context
Chapter 19 Cell Junctions, Cell Adhesion, and the Extracellular Matrix
Cell Junctions
Cell-Cell Adhesion
The Extracellular Matrix of Animals
Integrins
The Plant Cell Wall
References
Chapter 20 Germ Cells and Fertilization
The Benefits of Sex
Meiosis
Primordial Germ Cells and Sex Determination in Mammals
Eggs
Sperm
Fertilization
References
Chapter 21 Development of Multicellular Organisms
Universal Mechanisms of Animal Development
Caenorhabditis Elegans: Development from the Perspective of the Individual Cell
Drosophila and the Molecular Genetics of Pattern Formation: Genesis of the Body Plan
Homeotic Selector Genes and the Patterning of the Anteroposterior Axis
Organogenesis and the Patterning of Appendages
Cell Movements and the Shaping of the Vertebrate Body
The Mouse
Neural Development
Plant Development
References
Chapter 22 Histology: The Lives and Deaths of Cells in Tissues
Epidermis and Its Renewal by Stem Cells
Sensory Epithelia
The Airways and the Gut
Blood Vessels and Endothelial Cells
Renewal by Multipotent Stem Cells: Blood Cell Formation
Genesis, Modulation, and Regeneration of Skeletal Muscle
Fibroblasts and Their Transformations: The Connective-Tissue Cell Family
Stem-Cell Engineering
References
Chapter 23 Cancer
Cancer as a Microevolutionary Process
The Preventable Causes of Cancer
Finding the Cancer-Critical Genes
The Molecular Basis of Cancer-Cell Behavior
Cancer Treatment: Present and Future
References
Chapter 24 The Adaptive Immune System
Lymphocytes and the Cellular Basis of Adaptive Immunity
B Cells and Antibodies
The Generation of Antibody Diversity
T Cells and MHC Proteins
Helper T Cells and Lymphocyte Activation
References
Chapter 25 Pathogens, Infection, and Innate Immunity
Introduction to Pathogens
Cell Biology of Infection
Innate Immunity
References
Glossary
Copyright © 2002
Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, and James D. Watson
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