Table of Contents

• Book Information
• Preface to the Fifth Edition
• Acknowledgments
• Icons Used Throughout the Book
• Part I An Introduction to Immunobiology and Innate Immunity
  • Chapter 1 Basic Concepts in Immunology
    • The components of the immune system
    • Principles of innate and adaptive immunity
    • The recognition and effector mechanisms of adaptive immunity
    • Summary to Chapter 1
    • General references
  • Chapter 2 Innate Immunity
    • The front line of host defense
    • The complement system and innate immunity
    • Receptors of the innate immune system
    • Induced innate responses to infection
    • Summary to Chapter 2
    • General references
    • Section references
• Part II The Recognition of Antigen
  • Chapter 3 Antigen Recognition by B-cell and T-cell Receptors
    • The structure of a typical antibody molecule
    • The interaction of the antibody molecule with specific antigen
    • Antigen recognition by T cells
    • Summary to Chapter 3
    • General references
    • Section references
  • Chapter 4 The Generation of Lymphocyte Antigen Receptors
    • The generation of diversity in immunoglobulins
    • T-cell receptor gene rearrangement
    • Structural variation in immunoglobulin constant regions
    • Summary to Chapter 4
    • General references
    • Section references
  • Chapter 5 Antigen Presentation to T Lymphocytes
    • The generation of T-cell receptor ligands
    • The major histocompatibility complex and its functions
    • Summary to Chapter 5
    • General references
    • Section references
• Part III The Development of Mature Lymphocyte Receptor Repertoires
  • Chapter 6 Signaling Through Immune System Receptors
    • General principles of transmembrane signaling
    • Antigen receptor structure and signaling pathways
    • Other signaling pathways that contribute to lymphocyte behavior
    • Summary to Chapter 6
    • General references
    • Section references
  • Chapter 7 The Development and Survival of Lymphocytes
    • Generation of lymphocytes in bone marrow and thymus
    • The rearrangement of antigen-receptor gene segments controls lymphocyte development
    • Interaction with self antigens selects some lymphocytes for survival but eliminates others
    • Survival and maturation of lymphocytes in peripheral lymphoid tissues
    • Summary to Chapter 7
    • General references
    • Section references
• Part IV The Adaptive Immune Response
  • Chapter 8 T Cell-Mediated Immunity
    • The production of armed effector T cells
    • General properties of armed effector T cells
    • T cell-mediated cytotoxicity
    • Macrophage activation by armed CD4 T_H1 cells
    • Summary to Chapter 8
    • General references
    • Section references
  • Chapter 9 The Humoral Immune Response
    • B-cell activation by armed helper T cells
    • The distribution and functions of immunoglobulin isotypes
    • The destruction of antibody-coated pathogens via Fc receptors
    • Summary to Chapter 9
    • General references
    • Section references
  • Chapter 10 Adaptive Immunity to Infection
    • Infectious agents and how they cause disease
    • The course of the adaptive response to infection
    • The mucosal immune system
    • Immunological memory
    • Summary to Chapter 10
    • General references
    • Section references
• Part V The Immune System in Health and Disease
  • Chapter 11 Failures of Host Defense Mechanisms
    • Pathogens have evolved various means of evading or subverting normal host defenses
    • Inherited immunodeficiency diseases
    • Acquired immune deficiency syndrome
    • Summary to Chapter 11
    • General references
    • Section references
  • Chapter 12 Allergy and Hypersensitivity
    • The production of IgE
    • Effector mechanisms in allergic reactions
    • Hypersensitivity diseases
    • Summary to Chapter 12
    • General references
    • Section references
  • Chapter 13 Autoimmunity and Transplantation
    • Autoimmune responses are directed against self antigens
    • Responses to alloantigens and transplant rejection
    • Self-tolerance and its loss
    • Summary to Chapter 13
    • General references
    • Section references
  • Chapter 14 Manipulation of the Immune Response
    • Extrinsic regulation of unwanted immune responses
    • Using the immune response to attack tumors
    • Manipulating the immune response to fight infection
    • Summary to Chapter 14
    • General references
    • Section references
• Chapter 15 Afterword: Evolution of the Immune System: Past, Present, and Future, by Charles A. Janeway, Jr
  • Evolution of the innate immune system
  • Evolution of the adaptive immune response
  • The importance of immunological memory in fixing adaptive immunity in the genome
  • Future directions of research in immunobiology
  • Summary of the Afterword
• Appendices
  • Appendix I. Immunologists' Toolbox
  • Appendix II. CD Antigens
  • Appendix III. Cytokines and Their Receptors
  • Appendix IV. Chemokines and Their Receptors
  • Appendix V. Immunological Constants
• Biographies
• Glossary

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