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Immunobiology
The Immune System in Health and Disease
5th
Charles A
Janeway
,
1
Paul
Travers
,
2
Mark
Walport
,
3
and
Mark J
Shlomchik
1
1
Yale University School of Medicine
2
Anthony Nolan Research Institute, London
3
Imperial College School of Medicine, London
Garland Publishing, Inc
0-8153-3642-X
2001
© 2001
Garland Science
immunology
Table of Contents
Book Information
Preface to the Fifth Edition
Acknowledgments
Icons Used Throughout the Book
Part I An Introduction to Immunobiology and Innate Immunity
Chapter 1 Basic Concepts in Immunology
The components of the immune system
Principles of innate and adaptive immunity
The recognition and effector mechanisms of adaptive immunity
Summary to Chapter 1
General references
Chapter 2 Innate Immunity
The front line of host defense
The complement system and innate immunity
Receptors of the innate immune system
Induced innate responses to infection
Summary to Chapter 2
General references
Section references
Part II The Recognition of Antigen
Chapter 3 Antigen Recognition by B-cell and T-cell Receptors
The structure of a typical antibody molecule
The interaction of the antibody molecule with specific antigen
Antigen recognition by T cells
Summary to Chapter 3
General references
Section references
Chapter 4 The Generation of Lymphocyte Antigen Receptors
The generation of diversity in immunoglobulins
T-cell receptor gene rearrangement
Structural variation in immunoglobulin constant regions
Summary to Chapter 4
General references
Section references
Chapter 5 Antigen Presentation to T Lymphocytes
The generation of T-cell receptor ligands
The major histocompatibility complex and its functions
Summary to Chapter 5
General references
Section references
Part III The Development of Mature Lymphocyte Receptor Repertoires
Chapter 6 Signaling Through Immune System Receptors
General principles of transmembrane signaling
Antigen receptor structure and signaling pathways
Other signaling pathways that contribute to lymphocyte behavior
Summary to Chapter 6
General references
Section references
Chapter 7 The Development and Survival of Lymphocytes
Generation of lymphocytes in bone marrow and thymus
The rearrangement of antigen-receptor gene segments controls lymphocyte development
Interaction with self antigens selects some lymphocytes for survival but eliminates others
Survival and maturation of lymphocytes in peripheral lymphoid tissues
Summary to Chapter 7
General references
Section references
Part IV The Adaptive Immune Response
Chapter 8 T Cell-Mediated Immunity
The production of armed effector T cells
General properties of armed effector T cells
T cell-mediated cytotoxicity
Macrophage activation by armed CD4 T
H
1 cells
Summary to Chapter 8
General references
Section references
Chapter 9 The Humoral Immune Response
B-cell activation by armed helper T cells
The distribution and functions of immunoglobulin isotypes
The destruction of antibody-coated pathogens via Fc receptors
Summary to Chapter 9
General references
Section references
Chapter 10 Adaptive Immunity to Infection
Infectious agents and how they cause disease
The course of the adaptive response to infection
The mucosal immune system
Immunological memory
Summary to Chapter 10
General references
Section references
Part V The Immune System in Health and Disease
Chapter 11 Failures of Host Defense Mechanisms
Pathogens have evolved various means of evading or subverting normal host defenses
Inherited immunodeficiency diseases
Acquired immune deficiency syndrome
Summary to Chapter 11
General references
Section references
Chapter 12 Allergy and Hypersensitivity
The production of IgE
Effector mechanisms in allergic reactions
Hypersensitivity diseases
Summary to Chapter 12
General references
Section references
Chapter 13 Autoimmunity and Transplantation
Autoimmune responses are directed against self antigens
Responses to alloantigens and transplant rejection
Self-tolerance and its loss
Summary to Chapter 13
General references
Section references
Chapter 14 Manipulation of the Immune Response
Extrinsic regulation of unwanted immune responses
Using the immune response to attack tumors
Manipulating the immune response to fight infection
Summary to Chapter 14
General references
Section references
Chapter 15 Afterword
:
Evolution of the Immune System: Past, Present, and Future, by Charles A. Janeway, Jr
Evolution of the innate immune system
Evolution of the adaptive immune response
The importance of immunological memory in fixing adaptive immunity in the genome
Future directions of research in immunobiology
Summary of the Afterword
Appendices
Appendix I. Immunologists' Toolbox
Appendix II. CD Antigens
Appendix III. Cytokines and Their Receptors
Appendix IV. Chemokines and Their Receptors
Appendix V. Immunological Constants
Biographies
Glossary
Copyright © 2001
Garland Science
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