| Disease | Sensitivity | Cancer susceptibility | Complementation groups | Symptoms |
|---|---|---|---|---|
| Ataxia telangiectasia | γ irradiation | Lymphomas | 5 | Ataxia, dilation of blood vessels (telangiectases) in skin and eyes, chromosome aberrations, immune dysfunction |
| Bloom syndrome | Mild alkylating agents | Carcinomas, leukemias, lymphomas | 1 | Photosensitivity, facial telangiectases, chromosome alterations |
| Cockayne syndrome | UV light | 2 | Dwarfism, retinal atrophy, photosensitivity, progeria, deafness, trisomy 10 | |
| Fanconi anemia | Cross-linking agents | Leukemias | 3 | Hypoplastic pancytopenia, congenital anomalies |
| Xeroderma pigmentosum | UV light, chemical mutagens | Skin carcinomas and melanomas | 8 | Skin and eye photosensitivity, keratoses |
| HNPCC | Colon, ovary | 4 | Early development of tumors |
Note: Other human hereditary disorders that may be related to DNA-repair defects include dyskeratosis congenita (Zinsser-Cole-Engman syndrome), progeria (Hutchinson-Gilford syndrome), and trichothiodystrophy. HNPCC, hereditary nonpolyposis colorectal cancer.
Source: After A. Kornberg and T. Baker, DNA Replication, 2d ed. Copyright © 1992 by W. H. Freeman and Company.
