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AHRQ Technical Reviews and Summaries
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Chapter  13:  Empirical Evaluation of the Association Between Methodological Shortcomings and Estimates of Adverse Events

A12421

Prepared for:

Agency for Healthcare Research and Quality

U.S. Department of Health and Human Services

540 Gaither Road

Rockville, MD 20850

www.ahrq.gov

Contract No. 290-02-0024

Prepared by:

Oregon Evidence-based Practice Center, Portland, OR

Investigators

  • Roger Chou, M.D.

  • Rongwei Fu, Ph.D.

  • Susan Carson, M.P.H.

  • Somnath Saha, M.D., M.P.H.

  • Mark Helfand, M.D., M.P.H.

AHRQ Publication No. 06-0067

June 2006

This document is in the public domain and may be used and reprinted without permission except those copyrighted materials noted for which further reproduction is prohibited without the specific permission of copyright holders.

Suggested Citation:

Chou R, Fu R, Carson S, Saha S, Helfand M. Empirical Evaluation of the Association Between Methodological Shortcomings and Estimates of Adverse Events. Technical Review No. 13. (Prepared by the Oregon Evidence-based Practice Center under Contract No. 290-02-0024.) AHRQ Publication No. 06-0067. Rockville, MD: Agency for Healthcare Research and Quality. June 2006.

This report is based on research conducted by the Oregon Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-02-0024). The findings and conclusions in this document are those of the authors, who are responsible for its content, and do not necessarily represent the views of AHRQ. No statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services.

The information in this report is intended to help clinicians, employers, policymakers, and others make informed decisions about the provision of health care services. This report is intended as a reference and not as a substitute for clinical judgment.

This report may be used, in whole or in part, as the basis for the development of clinical practice guidelines and other quality enhancement tools, or as a basis for reimbursement and coverage policies. AHRQ or U.S. Department of Health and Human Services endorsement of such derivative products may not be stated or implied.

Dr. Saha was supported by a Research Career Development award from the Health Services Research and Development Service of the Department of Veterans Affairs and by a Generalist Physician Faculty Scholar award from the Robert Wood Johnson Foundation.

Prepared for:

Agency for Healthcare Research and Quality

U.S. Department of Health and Human Services

540 Gaither Road

Rockville, MD 20850

www.ahrq.gov

Contract No. 290-02-0024

Prepared by:

Oregon Evidence-based Practice Center, Portland, OR

Investigators

  • Roger Chou, M.D.

  • Rongwei Fu, Ph.D.

  • Susan Carson, M.P.H.

  • Somnath Saha, M.D., M.P.H.

  • Mark Helfand, M.D., M.P.H.

AHRQ Publication No. 06-0067

June 2006

This document is in the public domain and may be used and reprinted without permission except those copyrighted materials noted for which further reproduction is prohibited without the specific permission of copyright holders.

Suggested Citation:

Chou R, Fu R, Carson S, Saha S, Helfand M. Empirical Evaluation of the Association Between Methodological Shortcomings and Estimates of Adverse Events. Technical Review No. 13. (Prepared by the Oregon Evidence-based Practice Center under Contract No. 290-02-0024.) AHRQ Publication No. 06-0067. Rockville, MD: Agency for Healthcare Research and Quality. June 2006.

This report is based on research conducted by the Oregon Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-02-0024). The findings and conclusions in this document are those of the authors, who are responsible for its content, and do not necessarily represent the views of AHRQ. No statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services.

The information in this report is intended to help clinicians, employers, policymakers, and others make informed decisions about the provision of health care services. This report is intended as a reference and not as a substitute for clinical judgment.

This report may be used, in whole or in part, as the basis for the development of clinical practice guidelines and other quality enhancement tools, or as a basis for reimbursement and coverage policies. AHRQ or U.S. Department of Health and Human Services endorsement of such derivative products may not be stated or implied.

Dr. Saha was supported by a Research Career Development award from the Health Services Research and Development Service of the Department of Veterans Affairs and by a Generalist Physician Faculty Scholar award from the Robert Wood Johnson Foundation.

Contents

Preface

Acknowledgments

Structured Abstract

Chapter 1: Introduction

Chapter 2: Methods

Chapter 3: Results

Chapter 4: Discussion

References

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