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U.S. Preventive Services Task Force Evidence Syntheses, formerly Systematic Evidence Reviews
U.S. Preventive Services Task Force Evidence Syntheses
public health

Chapter  37:  Genetic Risk Assessment and BRCA Mutation Testing for Breast and Ovarian Cancer Susceptibility: Evidence Synthesis

A37278

Prepared for:

Agency for Healthcare Research and Quality

U.S. Department of Health and Human Services

540 Gaither Road

Rockville, MD 20850

www.ahrq.gov

Contract No. 290-02-0024

Task Order No. 2

Technical Support of the U.S. Preventive Services Task Force

Prepared by:

Oregon Evidence-based Practice Center

Portland, Oregon

Investigators

Heidi D. Nelson, MD, MPH

Laurie Hoyt Huffman, MS

Rongwei Fu, PhD

Emily L. Harris, PhD, MPH

Miranda Walker, BA

Christina Bougatsos, BS

September 2005

This report may be used, in whole or in part, as the basis of the development of clinical practice guidelines and other quality enhancement tools, or a basis for reimbursement and coverage policies. AHRQ or U.S. Department of Health and Human Services endorsement of such derivative products may not be stated or implied.

AHRQ is the lead Federal agency charged with supporting research designed to improve the quality of health care, reduce its cost, address patient safety and medical errors, and broaden access to essential services. AHRQ sponsors and conducts research that provides evidence-based information on health care outcomes; quality; and cost, use, and access. The information helps health care decisionmakers—patients and clinicians, health system leaders, and policymakers—make more informed decisions and improve the quality of health care services.

Prepared for:

Agency for Healthcare Research and Quality

U.S. Department of Health and Human Services

540 Gaither Road

Rockville, MD 20850

www.ahrq.gov

Contract No. 290-02-0024

Task Order No. 2

Technical Support of the U.S. Preventive Services Task Force

Prepared by:

Oregon Evidence-based Practice Center

Portland, Oregon

Investigators

Heidi D. Nelson, MD, MPH

Laurie Hoyt Huffman, MS

Rongwei Fu, PhD

Emily L. Harris, PhD, MPH

Miranda Walker, BA

Christina Bougatsos, BS

September 2005

This report may be used, in whole or in part, as the basis of the development of clinical practice guidelines and other quality enhancement tools, or a basis for reimbursement and coverage policies. AHRQ or U.S. Department of Health and Human Services endorsement of such derivative products may not be stated or implied.

AHRQ is the lead Federal agency charged with supporting research designed to improve the quality of health care, reduce its cost, address patient safety and medical errors, and broaden access to essential services. AHRQ sponsors and conducts research that provides evidence-based information on health care outcomes; quality; and cost, use, and access. The information helps health care decisionmakers—patients and clinicians, health system leaders, and policymakers—make more informed decisions and improve the quality of health care services.

Contents

Preface

Acknowledgments

Structured Abstract

Chapter 1. Introduction

Chapter 2. Methods

Chapter 3. Results

Chapter 4. Discussion

Appendix A. Search Strategies

Appendix B. Inclusion/Exclusion Criteria By Key Question

Appendix C. U.S. Preventive Services Task Force (USPSTF) Quality Rating Criteria

Appendix D. Statistical Methods

Appendix F. Reviewers

Appendix G. Evidence Table of Genetic Counseling Studies

Appendix H. Quality Ratings of Genetic Counseling Studies

Appendix I. Evidence Table of Studies of Prevalence and Penetrance

Appendix J. Evidence Table of Studies of Prevalence of Mutation Among Breast or Ovarian Cancer Cases

Appendix K. Evidence Table of Studies of Prevalence of Mutation Among Controls Without Breast or Ovarian Cancer

Appendix L. Evidence Table of Penetrance Studies

Appendix M. Evidence Table of Studies of Adverse Effects of Risk Assessment and Testing

Appendix N. Quality Ratings of Studies of Adverse Effects of Risk Assessment and Testing Studies

Appendix O. Evidence Table of Chemoprevention Trials

Appendix P. Quality Ratings of Chemoprevention Trials

Appendix Q. Evidence Table of Prophylactic Surgery Studies

Appendix R. Quality Ratings of Prophylactic Surgery Studies

Appendix S. Sensitivity Analyses

References

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