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Biology of the NMDA Receptor
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Biology of the NMDA Receptor
Van Dongen
Antonius M.
Duke University Medical Center, North Carolina
CRC Press/Taylor & Francis Group
2009
© 2009 by
Taylor & Francis Group, LLC
Frontiers in Neuroscience
Table of Contents
Series Preface
Preface
About the Editor
Contributors
1 NMDA Receptors and Brain Development
Rebecca C. Ewald and Hollis T. Cline
INTRODUCTION
DEVELOPMENTAL EXPRESSION PATTERNS OF NMDA RECEPTORS
NMDA RECEPTORS AND STRUCTURAL DEVELOPMENT OF NEURONS
NMDA RECEPTORS AND ACTIVITY-DEPENDENT DEVELOPMENT OF GLUTAMATERGIC SYNAPSES
CONCLUDING REMARKS
REFERENCES
2 NMDA Receptors and Huntington’s Disease
Herman B. Fernandes and Lynn A. Raymond
HUNTINGTON’S DISEASE
MODEL SYSTEMS FOR STUDY OF NMDA RECEPTOR FUNCTION IN HD
EXCITOTOXICITY HYPOTHESIS IN HD PATHOGENESIS
DOWNSTREAM CONSEQUENCES OF NMDA RECEPTOR ACTIVATION IN CELLS EXPRESSING MHTT
ALTERATIONS OF NMDA RECEPTOR-MEDIATED SYNAPTIC TRANSMISSION AND PLASTICITY IN HD
POSSIBLE MECHANISMS FOR MODULATION OF NMDA RECEPTOR FUNCTION BY MHTT
SUMMARY
REFERENCES
3 NMDA and Dopamine:
Diverse Mechanisms Applied to Interacting Receptor Systems
Carlos Cepeda, Véronique M. André, Emily L. Jocoy, and Michael S. Levine
INTRODUCTION
CLASSIFICATION AND MORPHOLOGICAL BASIS FOR INTERACTIONS AMONG GLUTAMATE AND DA RECEPTOR SUBTYPES
DA AND D1 RECEPTOR ENHANCEMENT OF NMDA RECEPTOR-MEDIATED RESPONSES
RECIPROCAL D1–NMDA RECEPTOR INTERACTIONS
TOPOGRAPHIC AND TEMPORAL ASPECTS OF D1–NMDA OCCURS RECEPTOR INTERACTIONS
REDUCTION OF NMDA RECEPTOR-MEDIATED RESPONSES BY DA OCCURS VIA D2 RECEPTORS
GENETIC MANIPULATIONS OF DA–NMDA RECEPTOR INTERACTIONS
FUNCTIONAL RELEVANCE OF DA–NMDA RECEPTOR INTERACTIONS
CONCLUSIONS
REFERENCES
4 The NMDA Receptor and Alcohol Addiction
Dorit Ron and Jun Wang
INTRODUCTION
ACUTE ETHANOL INHIBITION OF NMDA RECEPTOR FUNCTION
FACILITATION OF NMDA RECEPTOR FUNCTION BY ETHANOL
PHYSIOLOGICAL IMPLICATIONS OF MODULATION OF NMDA RECEPTOR FUNCTION BY ETHANOL
NMDA RECEPTORS AND BEHAVIORS ASSOCIATED WITH ETHANOL EXPOSURE
MODULATORS OF NMDA RECEPTOR FUNCTION AND TREATMENT OF ALCOHOL ABUSE AND DEPENDENCE
REFERENCES
5 Transcriptional Regulation of NMDA Receptor Expression
Guang Bai and Peter W. Hoffman
INTRODUCTION
IDENTIFICATION OF PROMOTER
REGULATORY UNITS:
CIS
ELEMENTS AND
TRANS
FACTORS
DEVELOPMENTAL EXPRESSION OF NR GENES
GROWTH FACTOR REGULATION OF NR GENES
CELL TYPE SPECIFICITY OF NR GENE EXPRESSION
NEUROLOGICAL DISORDERS
EPIGENETIC REGULATION
SUMMARY
REFERENCES
6 NMDA Receptors and Translational Control
Charles A. Hoeffer and Eric Klann
INTRODUCTION
OVERVIEW OF TRANSLATION
THREE STAGES OF TRANSLATION
RNA BINDING PROTEINS AND mRNA LOCALIZATION
ADMINISTERING TRANSLATION: NMDA RECEPTOR-DEPENDENT SIGNALING TO TRANSLATIONAL MACHINERY
NMDA RECEPTORS AND REGULATION OF TRANSLATIONAL SUBSTRATES
CONCLUDING THOUGHTS
REFERENCES
7 Regulation of NMDA Receptors by Kinases and Phosphatases
Michael W. Salter, Yina Dong, Lorraine V. Kalia, Xue Jun Liu, and Graham Pitcher
INTRODUCTION
NMDA RECEPTOR REGULATION BY SERINE AND THREONINE KINASES AND PHOSPHATASES
REGULATION OF NMDA RECEPTORS BY PROTEIN TYROSINE KINASES AND PHOSPHATASES
NMDA RECEPTOR PHOSPHORYLATION IN SYNAPTIC PLASTICITY
NMDA RECEPTOR PHOSPHORYLATION IN CENTRAL NERVOUS SYSTEM PATHOLOGY
CONCLUSIONS
REFERENCES
8 Trafficking and Targeting of NMDA Receptors
Ronald S. Petralia, Rana A. Al-Hallaq, and Robert J. Wenthold
INTRODUCTION
NMDA RECEPTOR TRANSPORT THROUGH THE BIOSYNTHETIC PATHWAY, AT THE SYNAPSE, AND FOLLOWING INTERNALIZATION
NMDA RECEPTOR TRAFFICKING AND DISEASE
REFERENCES
9 NMDA Receptor-Mediated Calcium Transients in Dendritic Spines
Brenda L. Bloodgood and Bernardo L. Sabatini
Introduction
SUBUNIT DEPENDENCE Of NMDA RECEPTOR-MEDIATED CALCIUM INFLUX
PHOSPHORYLATION-DEPENDENT REGULATION OF NMDA RECEPTOR-DEPENDENT CALCIUM ENTRY
VOLTAGE-DEPENDENT REGULATION OF SYNAPTICALLY EVOKED CALCIUM INFLUX
POSSIBLE EFFECTS OF COMPARTMENTALIZED ELECTRICAL SIGNALING ON NMDA RECEPTORS
IMPACT OF SPINE MORPHOLOGY ON CALCIUM SIGNALING IN DENDRITIC SPINES
CONCLUSION
REFERENCES
10 NMDA Receptors in
Drosophila
Shouzhen Xia and Ann-Shyn Chiang
INTRODUCTION
NMDA RECEPTOR HOMOLOGUES IN
DROSOPHILA
FUNCTIONAL EXPRESSION OF FLY NMDA RECEPTORS
EXPRESSION OF FLY NMDA RECEPTORS IN ADULT BRAIN
NMDA RECEPTOR-DEPENDENT LEARNING AND LONG-TERM MEMORY CONSOLIDATION
LOCALIZATION OF NMDA RECEPTOR-DEPENDENT MEMORIES
NMDA RECEPTORS IN OTHER INVERTEBRATES
SUMMARY
REFERENCES
11 Extracellular Modulation of NMDA Receptors
Keith Williams
INTRODUCTION
POLYAMINES
STRUCTURES OF NMDA RECEPTOR SUBUNITS AND RELEVANCE TO THE POLYAMINE SITE
IFENPRODIL
STRUCTURES OF NMDA RECEPTOR SUBUNITS AND RELEVANCE TO THE IFENPRODIL SITE
ZINC IONS
STRUCTURES OF NMDA RECEPTOR SUBUNITS AND RELEVANCE TO THE ZN
2+
SITE
PROTONS AND EXTRACELLULAR pH
WHITHER NEXT?
REFERENCES
12 Pharmacology of NMDA Receptors
Daniel T. Monaghan and David E. Jane
INTRODUCTION
PHARMACOLOGY OF THE NR2 GLUTAMATE BINDING SITE
PHARMACOLOGY OF GLYCINE BINDING SITE ON NR1
PHARMACOLOGY OF GLYCINE BINDING SITE ON NR3
ALLOSTERIC MODULATORY SITES ON NMDA Receptors
ZINC
UNCOMPETITIVE ANTAGONISTS (CHANNEL BLOCKERS)
CONCLUDING REMARKS
REFERENCES
13 Activation Mechanisms of the NMDA Receptor
Marie L. Blanke and Antonius M.J. VanDongen
INTRODUCTION
FUNCTION OF NMDA RECEPTORS
STRUCTURE AND ACTIVATION
CONCLUSIONS
REFERENCES
14 Presynaptic NMDA Receptors
Ian C. Duguid and Trevor G. Smart
INTRODUCTION
CRITERIA FOR DEFINING PRESYNAPTIC RECEPTORS
LOCATIONS OF NMDA RECEPTORS AT SYNAPSES
PHARMACOLOGY OF PRESYNAPTIC NMDA RECEPTORS
SOURCES OF GLUTAMATE
CONCLUSIONS
REFERENCES
List of Figures
Copyright © 2009 by
Taylor & Francis Group, LLC
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