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Dynamics of Cancer
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Dynamics of Cancer
2007
© 2007
Steven A. Frank
Table of Contents
Book Information
Introduction
Part I Background
Chapter 2 Age of Cancer Incidence
2.1 Incidence and Acceleration
2.2 Different Cancers
2.3 Childhood Cancers
2.4 Inheritance
2.5 Carcinogens
2.6 Sex Differences
2.7 Summary
Chapter 3 Multistage Progression
3.1 Terminology
3.2 What Is Multistage Progression?
3.3 Multistage Progression in Colorectal Cancer
3.4 Alternative Pathways to Colorectal Cancer
3.5 Changes during Progression
3.6 What Physical Changes Drive Progression?
3.7 What Processes Change during Progression?
3.8 How Do Changes Accumulate in Cell Lineages?
3.9 Summary
Part II Molecular Processes
Chapter 4 History of Theories
4.1 Origins of Multistage Theory
4.2 A Way to Test Multistage Models
4.3 Cancer Is a Genetic Disease
4.4 Can Normal Somatic Mutation Rates Explain Multistage Progression?
4.5 Clonal Expansion of Premalignant Stages
4.6 The Geometry of Cell Lineages
4.7 Hypermutation, Chromosomal Instability, and Selection
4.8 Epigenetics: Methylation and Acetylation
4.9 Summary
Chapter 5 Progression Dynamics
5.1 Background
5.2 Observations to Be Explained
5.3 Progression Dynamics through Multiple Stages
5.4 Why Study Quantitative Theories?
5.5 The Basic Model
5.6 Technical Definitions of Incidence and Acceleration
5.7 Summary
Part III Individual Interactions
Chapter 6 Theory I
6.1 Approach
6.2 Solution with Equal Transition Rates
6.3 Parallel Evolution within Each Individual
6.4 Unequal Transition Rates
6.5 Time-Varying Transition Rates
6.6 Summary
Chapter 7 Theory II
7.1 Multiple Pathways of Progression
7.2 Discrete Genetic Heterogeneity
7.3 Continuous Genetic and Environmental Heterogeneity
7.4 Weibull and Gompertz Models
7.5 Weibull Analysis of Carcinogen Dose-Response Curves
7.6 Summary
Part IV Population Consequences
Chapter 8 Genetics of Progression
8.1 Comparison between Genotypes in Human Populations
8.2 Comparison between Genotypes in Laboratory Populations
8.3 Polygenic Heterogeneity
8.4 Summary
Chapter 9 Carcinogens
9.1 Carcinogen Dose-Response
9.2 Cessation of Carcinogen Exposure
9.3 Mechanistic Hypotheses and Comparative Tests
9.4 Summary
Chapter 10 Aging
10.1 Leading Causes of Death
10.2 Multistage Hypotheses
10.3 Reliability Models
10.4 Conclusions
10.5 Summary
Part V Studying Evolution
Chapter 11 Inheritance
11.1 Genetic Variants Affect Progression and Incidence
11.2 Progression and Incidence Affect Genetic Variation
11.3 Few Common or Many Rare Variants?
11.4 Summary
Chapter 12 Stem Cells: Tissue Renewal
12.1 Background
12.2 Stem-Transit Program of Renewal
12.3 Symmetric versus Asymmetric Stem Cell Divisions
12.4 Asymmetric Mitoses and the Stem Line Mutation Rate
12.5 Tissue Compartments and Repression of Competition
12.6 Summary
Chapter 13 Stem Cells: Population Genetics
13.1 Mutations during Development
13.2 Stem-Transit Design
13.3 Symmetric versus Asymmetric Mitoses
13.4 Summary
Chapter 14 Cell Lineage History
14.1 Reconstructing Cellular Phylogeny
14.2 Demography of Progression
14.3 Somatic Mosaicism
14.4 Summary
Conclusions
Appendix: Incidence
References
List of Figures
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Copyright © 2007
Steven A. Frank
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