Search for
Within
This book
All books
PubMed
NCBI
»
Bookshelf
»
The Genetic Landscape of Diabetes
»
diabetes
The Genetic Landscape of Diabetes
Laura
Dean
1
and
Jo
McEntyre
1
National Center for Biotechnology Information (NCBI), National Library of Medicine, National Institutes of Health, Bethesda, MD 20892-6510
National Center for Biotechnology Information (NCBI)
2004
© 2004
Copyright and disclaimer
medical genetics
Table of Contents
Preface
Book Information
Chapter 1 Introduction to Diabetes
Initial Posting: July 7, 2004
Classification
History of Diabetes
Epidemiology
Physiology and Biochemistry of Sugar Regulation
The Story of Insulin
Chapter 2 Genetic Factors in Type 1 Diabetes
Initial Posting: July 7, 2004
IDDM1 Contains the HLA Genes
IDDM2 Contains the Insulin Gene (INS)
Other Type 1 Diabetes Susceptibility Loci: IDDM3–IDDM18
An Inhibitor of the Immune Response (CTLA4)
Chapter 3 Genetic Factors in Type 2 Diabetes
Initial Posting: July 7, 2004
The Sulfonylurea Receptor (ABCC8)
The Calpain 10 Enzyme (CAPN10)
The Glucagon Receptor (GCGR)
The Enzyme Glucokinase (GCK)
The Glucose Transporter GLUT2
The Transcription Factor HNF4A
The Insulin Hormone (INS)
The Insulin Receptor (INSR)
The Potassium Channel KCNJ11
The Enzyme Lipoprotein Lipase (LPL)
The Transcription Factor PPARG
The Regulatory Subunit of a Phosphorylating Enzyme (PIK3R1)
Chapter 4 Other Types of Diabetes
Initial Posting: July 7, 2004
Genetic Defects of Beta Cell Function (MODY and Others)
MODY1: Caused by a Mutation in Transcription Factor HNF4A
MODY2: Caused by a Mutation in the Enzyme Glucokinase (GCK)
MODY3: Caused by a Mutation in Transcription Factor TCF1
MODY4: Caused by a Mutation in Transcription Factor IPF1
MODY5: Caused by a Mutation in Transcription Factor TCF2
MODY6: Caused by a Mutation in Transcription Factor NEUROD1
Genetic Defects in Insulin Action
Diseases in the Exocrine Pancreas
Diseases of the Endocrine System
Drug- or Chemical-induced Diabetes
Infections
Uncommon Forms of Immune-mediated Diabetes
Other Genetic Syndromes Sometimes Associated with Diabetes
Chapter 5 Gestational Diabetes
Initial Posting: July 7, 2004
References
NIH Lectures
© 2004
Copyright and disclaimer
Help
ǀ
Contact Bookshelf
Expand All
Collapse All