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Table 21.2

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   Some agents thought to cause disruptions in human fetal developmenta

DRUGS AND CHEMICALSIONIZING RADIATION (X-RAYS)
AlcoholHYPERTHERMIA
Aminoglycosides (Gentamycin)INFECTION MICROORGANISMS
AminopterinCoxsackie virus
Antithyroid agents (PTU)Cytomegalovirus
BromineHerps simplex
Cigarette smokeParvovirus
CocaineRubella (German measles)
CortisoneToxoplasma gondii (toxoplasmosis)
Diethylstilbesterol (DES)Treponema Pallidum (syphilis)
DiphenylhydantoinMETABOLIC CONDITIONS IN THE MOTHER
HeroinAutoimmune disease (including Rh incompatibility)
LeadDiabetes
MethylmercuryDietary deficiencies, malnutrition
PenicillaminePhenylketonuria
Retinoic acid (Isotretinoin, Accutane)
Streptomycin
Tetracycline
Thalidomide
Trimethadione
Valproic acid
Warfarin

Source: Adapted from Opitz 1991.

a

This list includes known and possible teratogenic agents and is not exhaustive.