Table of Contents

• Acknowledgments
• Preface
• Part 1 Principles of development in biology
  • Chapter 1 Developmental biology: The anatomical tradition
    • The Questions of Developmental Biology
    • Anatomical Approaches to Developmental Biology
    • Comparative Embryology
    • Evolutionary Embryology
    • Medical Embryology and Teratology
    • Mathematical Modeling of Development
    • Principles of Development: Developmental Anatomy
    • References
  • Chapter 2 Life cycles and the evolution of developmental patterns
    • The Circle of Life: The Stages of Animal Development
    • The Frog Life Cycle
    • The Evolution of Developmental Patterns in Unicellular Protists
    • Multicellularity: The Evolution of Differentiation
    • Developmental Patterns among the Metazoa
    • Principles of Development: Life Cycles and Developmental Patterns
    • References
  • Chapter 3 Principles of experimental embryology
    • Environmental Developmental Biology
    • The Developmental Mechanics of Cell Specification
    • Morphogenesis and Cell Adhesion
    • Principles of Development: Experimental Embryology
    • References
  • Chapter 4 Genes and development: Techniques and ethical issues
    • The Embryological Origins of the Gene Theory
    • Evidence for Genomic Equivalence
    • Differential Gene Expression
    • RNA Localization Techniques
    • Determining the Function of Genes during Development
    • Identifying the Genes for Human Developmental Anomalies
    • Principles of Development: Genes and Development
    • References
  • Chapter 5 The genetic core of development: Differential gene expression
    • Differential Gene Transcription
    • Methylation Pattern and the Control of Transcription
    • Transcriptional Regulation of an Entire Chromosome: Dosage Compensation
    • Differential RNA Processing
    • Control of Gene Expression at the Level of Translation
    • Epilogue: Posttranslational Gene Regulation
    • Principles of Development: Developmental Genetics
    • References
  • Chapter 6 Cell-cell communication in development
    • Induction and Competence
    • Paracrine Factors
    • Cell Surface Receptors and Their Signal Transduction Pathways
    • The Cell Death Pathways
    • Juxtacrine Signaling
    • Cross-Talk between Pathways
    • Coda
    • Principles of Development:Cell-Cell Communication
    • References
• Part 2 Early embryonic development
  • Chapter 7 Fertilization: Beginning a new organism
    • Structure of the Gametes
    • Recognition of Egg and Sperm
    • Gamete Fusion and the Prevention of Polyspermy
    • The Activation of Egg Metabolism
    • Fusion of the Genetic Material
    • Rearrangement of the Egg Cytoplasm
    • Snapshot Summary: Fertilization
    • References
  • Chapter 8 Early development in selected invertebrates
    • An Introduction to Early Developmental Processes
    • The Early Development of Sea Urchins
    • The Early Development of Snails
    • Early Development in Tunicates
    • Early Development of the Nematode Caenorhabditis elegans
    • References
  • Chapter 9 The genetics of axis specification in Drosophila
    • Early Drosophila Development
    • The Origins of Anterior-Posterior Polarity
    • The Generation of Dorsal-Ventral Polarity
    • References
  • Chapter 10 Early development and axis formation in amphibians
    • Early Amphibian Development
    • Axis Formation in Amphibians: The Phenomenon of the Organizer
    • References
  • Chapter 11 The early development of vertebrates: Fish, birds, and mammals
    • Early Development in Fish
    • Early Development in Birds
    • Early Mammalian Development
    • References
• Part 3 Later embryonic development
  • Chapter 12 The central nervous system and the epidermis
    • Formation of the Neural Tube
    • Differentiation of the Neural Tube
    • Tissue Architecture of the Central Nervous System
    • Neuronal Types
    • Development of the Vertebrate Eye
    • The Epidermis and the Origin of Cutaneous Structures
    • Snapshot Summary: Central Nervous System and Epidermis
    • References
  • Chapter 13 Neural crest cells and axonal specificity
    • The Neural Crest
    • Neuronal Specification and Axonal Specificity
    • References
  • Chapter 14 Paraxial and intermediate mesoderm
    • Paraxial Mesoderm: The Somites and Their Derivatives
    • Myogenesis: The Development of Muscle
    • Osteogenesis: The Development of Bones
    • Intermediate Mesoderm
    • Snapshot Summary: Paraxial and Intermediate Mesoderm
    • References
  • Chapter 15 Lateral plate mesoderm and endoderm
    • Lateral Plate Mesoderm
    • Endoderm
    • References
  • Chapter 16 Development of the tetrapod limb
    • Formation of the Limb Bud
    • Generating the Proximal-Distal Axis of the Limb
    • Specification of the Anterior-Posterior Limb Axis
    • The Generation of the Dorsal-Ventral Axis
    • Coordination among the Three Axes
    • Cell Death and the Formation of Digits and Joints
    • Snapshot Summary: The Tetrapod Limb
    • References
  • Chapter 17 Sex determination
    • Chromosomal Sex Determination in Mammals
    • Chromosomal Sex Determination in Drosophila
    • Environmental Sex Determination
    • Snapshot Summary: Sex Determination
    • References
  • Chapter 18 Metamorphosis, regeneration, and aging
    • Metamorphosis: The Hormonal Reactivation of Development
    • Regeneration
    • Aging: The Biology of Senescence
    • References
  • Chapter 19 The saga of the germ line
    • Germ Plasm and the Determination of the Primordial Germ Cells
    • Germ Cell Migration
    • Meiosis
    • Spermatogenesis
    • Oogenesis
    • Snapshot Summary: The Germ Line
    • References
• Part 4 Ramifications of developmental biology
  • Chapter 20 An overview of plant development
    • Plant Life Cycles
    • Gamete Production in Angiosperms
    • Pollination
    • Fertilization
    • Embryonic Development
    • Dormancy
    • Germination
    • Vegetative Growth
    • The Vegetative-to-Reproductive Transition
    • Senescence
    • Snapshot Summary: Plant Development
    • References
  • Chapter 21 Environmental regulation of animal development
    • Environmental Regulation of Normal Development
    • Environmental Disruption of Normal Development
    • References
  • Chapter 22 Developmental mechanisms of evolutionary change
    • “Unity of Type” and “Conditions of Existence”
    • Hox Genes: Descent with Modification
    • Homologous Pathways of Development
    • Modularity: The Prerequisite for Evolution through Development
    • Developmental Correlation
    • Developmental Constraints
    • A New Evolutionary Synthesis
    • Snapshot Summary: Evolutionary Developmental Biology
    • References
• Appendix

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