 |
| Regimen | Dose (mg/m2) | Days Administered | Frequency | |
|---|---|---|---|---|
| First-Generation | ||||
 C-MOPP | Cyclophosphamide | 650 IV | 1 and 8 | q 28 d |
| Vincristine | 1.4 IV | 1 and 8 | ||
| Procarbazine | 100 PO | 1 to 14 | ||
| Prednisone | 100 PO | 1 to 14 | ||
| Cyclophosphamide | 750 IV | 1 | q 21 d | |
| CHOP | Doxorubicin | 50 IV | 1 | |
| Vincristine | 1.4 IV | 1 | ||
| Prednisone | 100 PO | 1 to 5 | ||
| BACOP | Bleomycin | 5 IV | 15 and 21 | q 28 d |
| Doxorubicin | 25 IV | 1 and 8 | ||
| Cyclophosphamide | 650 IV | 1 and 8 | ||
| Vincristine | 1.4 IV | 1 and 8 | ||
| Prednisone | 60 PO | 15 to 28 | ||
| COMLA | Cyclophosphamide | 1500 IV | 1 | q 91 d |
| Vincristine | 1.4 IV | 1, 8 and 15 | ||
| Methotrexate | 120 IV | 22 and then q week x 7 | ||
| Leucovorin | 25 IV | q6h x 4 with MTX | ||
| Cytosine arabinoside | 300 IV | 22 and weekly x 7 | ||
| CAP-BOP | Cyclophosphamide | 650 IV | 1 | q 21 d |
| Doxorubicin | 50 IV | 1 | ||
| Procarbazine | 100 PO | 1 to 7 | ||
| Bleomycin | 10SC | 1 | ||
| Vincristine | 1.4 IV | 15 | ||
| Prednisone | 100 PO | 15 to 21 | ||
| Second-Generation | ||||
| M-BACOD | Methotrexate | 200 IV | 8 and 15 | q 21 d |
| Bleomycin | 4 IV | 1 | ||
| Doxorubicin | 45 IV | 1 | ||
| Cyclophosphamide | 600 IV | 1 | ||
| Vincristine | 1 IV | 1 | ||
| Dexamethasone | 6 PO | 1 to 5 | ||
| Leucovorin | 10 PO | 24 h after MTX then q6h for 8 doses | ||
| ProMACE/MOPP | Prednisone | 60 PO | 1 to 15 | q 28 d |
| Methotrexate | 1500 IV | 15 | ||
| Doxorubicin | 25 IV | 1 and 8 | ||
| Cyclophosphamide | 650 IV | 1 and 8 | ||
| Etoposide | 120 IV | 1 and 8 | ||
| Leucovorin | 50 IV | 24 h after MTX then q6h for 5 doses | ||
| Standard MOPP | After remission | q 28 d | ||
| Third-Generation | ||||
| ProMACE/CytaBOM | Prednisone | 60 PO | 1 to 14 | q 28 d |
| Methotrexate | 1500 IV | 15 | ||
| Doxorubicin | 25 IV | 1 | ||
| Cyclophosphamide | 650 IV | 1 | ||
| Etoposide | 120 IV | 1 | ||
| Cyclosine arabinoside | 300 IV | 8 | ||
| Bleomycin | 5 IV | 8 | ||
| Vincristine | 1.4 IV | 8 | ||
| Methotrexate | 120 IV | 8 | ||
| Leucovorin | 25 IV | 24 h after MTX then q6h for 5 doses | ||
| MACOP-B | Methotrexate | 400 IV | 8 | q 28 d x 3 |
| Doxorubicin | 50 IV | 1 and 15 | ||
| Cyclophosphamide | 350 IV | 1 and 15 | ||
| Vincristine | 1.4 IV | 8 and 22 | ||
| Prednisone fixed dose | 75 PO | daily for 12 weeks | ||
| Bleomycin | 10 IV | 28 | ||
| Leucovorin | 15 PO | 24 h after MTX then q6h for 6 doses | ||
| COP-BLAM III | Cyclophosphamide | 350 IV | 1 | q 21 d |
| Vincristine | 1.0 IV | 1 and 2 (on alternate cycles) | ||
| Prednisone | 40 PO | 1 to 5 | ||
| Bleomycin | 7.5 IV | daily infusion x 5 d | ||
| Doxorubicin | 35 IV | 1 | ||
| Procarbazine | 100 PO | 1 to 5 | ||