-- Cancer Medicine -- NCBI Bookshelf

Book Information
Editors
Contributors
Preface
Section 1 Cancer Biology
- Chapter 1 Molecular Biology Barrett J Rollins, MD, Todd R Golub, MD, Kornelia Polyak, MD, and Charles D Stiles, PhD
- Chapter 2 Cell Proliferation, Differentiation, and Apoptosis Michael Andreeff, MD, David W Goodrich, MD, and Arthur B Pardee, MD
- Chapter 3 Growth Factor Signal Transduction in Cancer Paolo Fedi, MD, Alec Kimmelman, MD, and Stuart A Aaronson, MD
- Chapter 4 Oncogenes Marco A Pierotti, MD, Steven A Schichman, MD, Gabriella Sozzi, and Carlo M Croce, MD
- Chapter 5 Tumor Suppressor Gene Defects in Human Cancer Eric R Fearon, MD and Bert Vogelstein, MD
- Chapter 6 Recurring Chromosome Rearrangements in Human Cancer Olufunmilayo I Olopade, MD, Olatoyosi M Sobulo, MD, and Janet D Rowley, MD
- Chapter 7 Biochemistry of Cancer Raymond W Ruddon, MD
- Chapter 8 Invasion and Metastases Lance A Liotta, MD and Elise C Kohn, MD
- Chapter 9 Tumor Angiogenesis Judah Folkman, MD
Section 2 Tumor Immunology
- Chapter 10 Tumor Immunology Jeffrey Schlom, PhD and Scott I Abrams, PhD
Section 3 Cancer Etiology
- Chapter 11 Genetic Predisposition to Cancer Marcia S Brose, MD, Tom Smyrk, MD, Barbara Weber, MD, and Henry T Lynch, MD
- Chapter 12 Chemical Carcinogenesis Ainsley Weston, PhD and Curtis C Harris, MD
- Chapter 13 Hormones and the Etiology of Cancer Brian E Henderson, MD, Leslie Bernstein, PhD, and Ronald K Ross, MD
- Chapter 14 Ionizing Radiation John B Little, MD
- Chapter 15 Ultraviolet Radiation Carcinogenesis James E Cleaver, PhD and David L Mitchell, PhD
- Chapter 16 Physical Carcinogens Cesare Maltoni, MD, Franco Minardi, MD, and James F Holland, MD
- Chapter 17 Trauma and Inflammation John F Gaeta, MD
- Chapter 18 Tumor Viruses Howard A Fine, MD and Joseph G Sodroski, MD
- Chapter 19 Herpesviruses Jeffrey I Cohen, MD
- Chapter 20 Papillomaviruses and Cervical Neoplasia Catherine M McLachlin, MD and Christopher P Crum, MD
- Chapter 21 Hepatitis Viruses Max W Sung, MD, Swan N Thung, MD, and George Acs, MD
- Chapter 22 Parasites Piero Mustacchi, MD
Section 4 Cancer Epidemiology
- Chapter 23 Cancer Epidemiology Michael J Thun, MD and Phyllis A Wingo, PhD
Section 5 Theory and Practice of Clinical Trials
- Chapter 24 Theory and Practice of Clinical Trials Marvin Zelen, PhD
Section 6 Cancer Prevention
- Chapter 25 Prevention of Tobacco-Related Cancers Paul F Engstrom, MD, Margie Clapper, PhD, Robert A Schnoll, PhD, and C. Tracy Orleans, PhD
- Chapter 26 Nutrition in the Etiology and Prevention of Cancer Steven K Clinton, MD, Elizabeth C Miller, MS, and Edward L Giovannucci, MD
- Chapter 27 Chemoprevention of Cancer Michael B Sporn, MD and Scott M Lippman, MD
Section 7 Cancer Screening and Early Detection
- Chapter 28 Cancer Screening and Early Detection Harmon J Eyre, MD, Robert A Smith, PhD, and Curtis J Mettlin, PhD
Section 8 Principles of Cancer Pathology
- Chapter 29 Principles of Cancer Pathology James L Connolly, MD, Stuart J Schnitt, MD, Helen H Wang, MD, Ann M Dvorak, MD, and Harold F Dvorak, MD
Section 9 Principles of Imaging
- Chapter 30 Principles of Imaging Richard J Steckel, MD
- Chapter 30A Imaging Cancer of Unknown Primary Site A. Robert Kagan, MD and Richard J Steckel, MD
- Chapter 30B Imaging Neoplasms of the Head and Neck and Central Nervous System Robert B Lufkin, MD
- Chapter 30C Imaging Neoplasms of the Thorax Poonam V Batra, MD
- Chapter 30D Imaging Neoplasms of the Abdomen and Pelvis Robert A Halvorsen Jr, MD and William M Thompson, MD
- Chapter 30E Cross-Sectional Imaging of Musculoskeletal Neoplasms Leanne L Seeger, MD
- Chapter 30F Imaging the Breast Lawrence W Bassett, MD
- Chapter 30G Ultrasound in Cancer Medicine Edward G Grant, MD
- Chapter 30H Radionuclide Imaging in Cancer Medicine Randall A Hawkins, MD
- Chapter 30I Perspectives in Imaging Richard J Steckel, MD
- Chapter 31 Interventional Radiology for the Cancer Patient Marshall Hicks, MD, Chusilp Charnsangavej, MD, and Michael Wallace, MD
Section 10 Principles of Surgical Oncology
- Chapter 32 Principles of Surgical Oncology Raphael E Pollock, MD and Donald L Morton, MD
- Chapter 33 Vascular Access in Cancer Patients Michail Shafir, MD
Section 11 Principles of Radiation Oncology
- Chapter 34 Physical and Biologic Basis of Radiation Oncology Arno J Mundt, MD, John C Roeske, PhD, and Ralph R Weichselbaum, MD
- Chapter 35 Principles of Hyperthermia Daniel S Kapp, PhD, George M Hahn, PhD, and Robert W Carlson, MD
- Chapter 36 Photodynamic Therapy of Cancer Tayyaba Hasan, PhD, Anne C E Moor, PhD, and Bernard Ortel, MD
Section 12 Principles of Medical Oncology
- Chapter 37 Principles of Medical Oncology James F Holland, MD, Emil Frei III, MD, Donald W Kufe, MD, and Robert C Bast Jr, MD
Section 13 Principles of Chemotherapy
- Chapter 38 Cytokinetics Teresa Ann Gilewski, MD, Chau Dang, MD, Antonella Surbone, MD, and Larry Norton, MD
- Chapter 39 Drug Resistance and Its Clinical Circumvention Charles S Morrow, MD and Kenneth H Cowan, MD
- Chapter 40 Principles of Dose, Schedule, and Combination Chemotherapy Emil Frei III, MD and Karen H Antman, MD
- Chapter 41 Regional Chemotherapy Maurie Markman, MD
- Chapter 42 Animal Models in Developmental Therapeutics Samir N Khleif, MD and Gregory A Curt, MD
- Chapter 43 In Vitro and In Vivo Predictive Tests A. R Hanauske, MD
- Chapter 44 Pharmacology Mark J Ratain, MD and William Plunkett, MD
- Chapter 45 Toxicology by Organ System Michael R Grever, MD and Charles K Grieshaber, PhD
Section 14 Chemotherapeutic Agents
- Chapter 46 Folate Antagonists Barton A Kamen, MD, Peter D Cole, MD, and Joseph R Bertino, MD
- Chapter 47 Pyrimidine and Purine Antimetabolites Giuseppe Pizzorno, MD, Robert E Handschumacher, MD, and Yung-Chi Cheng, MD
- Chapter 48 Alkylating Agents and Platinum Antitumor Compounds D. Michael Colvin, MD
  - Alkylating Agents
  - References
- Chapter 49 Anthracyclines and DNA Intercalators/Epipodophyllotoxins/DNA Topoisomerases Eric H Rubin, MD and William N Hait, MD
- Chapter 50 Microtubule-Targeting Anticancer Drugs Derived from Plants and Microbes: Vinca Alkaloids, Taxanes, and Epothilones William T Beck, PhD, Carol E Cass, PhD, and Peter J Houghton, PhD
- Chapter 51 Asparaginase JoAnne Kurtzberg, MD
Section 15 Principles of Endocrine Therapy
- Chapter 52 Steroid Hormone Binding and Hormone Receptors Eugene R DeSombre, PhD and Elwood V Jensen, PhD
- Chapter 53 Hypothalamic and Other Peptide Hormones Andrew V Schally, PhD and Ana Maria Comaru-Schally, MD
- Chapter 54 Corticosteroids Lorraine I McKay, PhD and John A Cidlowski, PhD
- Chapter 55 Estrogens and Antiestrogens V. Craig Jordan, PhD
- Chapter 56 Clinical Use of Aromatase Inhibitors in Breast Carcinoma Harold A Harvey, MD
- Chapter 57 Progestins Kenneth S McCarty Jr, MD and Kenneth S McCarty Sr, PhD
- Chapter 58 Androgen Deprivation Strategies in the Treatment of Advanced Prostate Cancer Samuel R Denmeade, MD and John T Isaacs, PhD
- Chapter 59 Paraneoplastic Syndromes William D Odell, MD
Section 16 Principles of Biotherapeutics
- Chapter 60 Immunostimulants Robert C Bast Jr, MD and Donald L Morton, MD
- Chapter 61 Active Specific Immunotherapy with Vaccines Mepur H Ravindranath, PhD and Donald L Morton, MD
- Chapter 62 Interferons Ernest C Borden, MD and Bryan R G Williams, PhD
- Chapter 63 Cytokines: Biology and Applications in Cancer Medicine Elizabeth A Grimm, PhD
- Chapter 64 Hematopoietic Growth Factors Razelle Kurzrock, MD
- Chapter 65 Monoclonal Serotherapy Robert C Bast Jr, MD, Michael R Zalutsky, PhD, Robert J Kreitman, MD, Edward A Sausville, MD, and Arthur E Frankel, MD
Section 17 Principles of Gene Therapy
- Chapter 66 Cancer Gene Therapy Donald W Kufe, MD, Sunil Advani, MD, and Ralph Weichselbaum, MD
Section 18 Principles of Bone Marrow Transplantation
- Chapter 67 Autologous Bone Marrow and Stem Cell Transplantation William P Peters, MD, Caroline Hamm, MD, and Roy D Baynes, MD
- Chapter 68 Transplantation of Allogeneic Hematopoietic Cells for the Treatment of Malignancies Richard J O’Reilly, MD, Esperanza B Papadopoulos, MD, and Trudy N Small, MD
Section 19 Principles of Psycho-Oncology
- Chapter 69 Principles of Psycho-Oncology Jimmie C Holland, MD and Jane Gooen-Piels, PhD
Section 20 Principles of Oncology Nursing
- Chapter 70 Principles of Oncology Nursing Mary Johnson, RN and Connie Henke Yarbro, RN
Section 21 Principles of Cancer Rehabilitation Medicine
- Chapter 71 Principles of Cancer Rehabilitation Medicine Kristjan T Ragnarsson, MD and David C Thomas, MD
Section 22 Principles of Multidisciplinary Management
- Chapter 72 Principles of Multidisciplinary Management James F Holland, MD, Emil Frei III, MD, Donald W Kufe, MD, Robert C Bast Jr, MD, Raphael E Pollock, MD, and Ralph R Weichselbaum, MD
- Chapter 73 Palliative Care Alan C Carver, MD and Kathleen M Foley, MD
Section 23 Principles of Societal Oncology
- Chapter 74 Ethical Aspects of Caring for Patients with Cancer Ezekiel J Emanuel, MD and Steven Joffe, MD
- Chapter 75 Legal Aspects of Cancer Joseph M Taraska, PA
- Chapter 76 The Government and Cancer Medicine John E Ultmann, MD, Marguerite Donoghue Baxter, RN, and Terry Lierman
- Chapter 77 Clinical Oncology in a Changing Healthcare Environment Martin N Raber, MD and Joseph S Bailes, MD
- Chapter 78 Outcomes Assessment Jane C Weeks, MD
- Chapter 79 Questionable Cancer Therapies Barrie R Cassileth, PhD
Section 24 Neoplasms of the Central Nervous System
- Chapter 80 Neoplasms of the Central Nervous System Michael D Prados, MD
Section 25 Neoplasms of the Eye
- Chapter 81 Neoplasms of the Eye David H Abramson, MD, Ira J Dunkel, MD, and Beryl McCormick, MD
Section 26 Neoplasms of the Endocrine Glands
- Chapter 82 Pituitary Neoplasms Aviva Abosch, MD and Charles B Wilson, MD
- Chapter 83 Neoplasms of the Thyroid Steven I Sherman, MD and Ann M Gillenwater, MD
- Chapter 84 Neoplasms of the Adrenal Cortex David E Schteingart, MD
- Chapter 85 Neoplasms of the Neuroendocrine System and Neoplasms of the Gastroenteropancreatic Endocrine System Larry K Kvols, MD, Roger R Perry, MD, Aaron I Vinik, MD, Li-teh Wu, MD, Phillippe Chaninian, MD, Stephen B Baylin, MD, and Norman W Thompson, MD
Section 27 Neoplasms of the Head and Neck
- Chapter 86 Head and Neck Cancer Gary L Clayman, MD, Scott M Lippman, MD, George E Laramore, MD, and Waun Ki Hong, MD
- Chapter 87 Odontogenic Tumors George Thomas Gallagher, DMD and Gerald Shklar, DDS
  - Clinical, Radiographic, and Histologic Features
  - References
Section 28 Neoplasms of the Thorax
- Chapter 88 Cancer of the Lung Ara A Vaporciyan, MD, Jonathan C Nesbitt, MD, Jin Soo Lee, MD, Craig Stevens, MD, Ritsuko Komaki, MD, and Jack A Roth, MD
- Chapter 89 Malignant Mesothelioma A. Philippe Chahinian, MD and Harvey I Pass, MD
- Chapter 90 Thymomas and Thymic A. Philippe Chahinian, MD
- Chapter 91 Tumors of the Heart and Great Vessels A. Philippe Chahinian, MD, David E Gutstein, MD, and Valentin Fuster, MD
- Chapter 92 Primary Germ Cell Tumors of the Thorax John D Hainsworth, MD and F. Anthony Greco, MD
- Chapter 93 Metastatic Tumors in the Thorax Donald L Morton, MD and Perry Shen, MD
Section 29 Neoplasms of the Alimentary Canal
- Chapter 94 Neoplasms of the Esophagus Mark K Ferguson, MD
- Chapter 95 Neoplasms of the Stomach Howard W Bruckner, MD, John C Morris, MD, and Paul Mansfield, MD
- Chapter 96 Primary Neoplasms of the Liver Paul F Engstrom, MD, Elin Sigurdson, MD, and Alison A Evans, PhD
- Chapter 97 Treatment of Liver Metastases Nancy E Kemeny, MD and Yuman Fong, MD
- Chapter 98 The Gallbladder Steven A Curley, MD
  - Gallbladder Carcinoma
  - References
- Chapter 99 Diagnosis and Management of Biliary Tract Cancer Steven A Curley, MD
- Chapter 100 Neoplasms of the Ampulla of Vater Douglas B Evans, MD and Robert A Wolff, MD
- Chapter 101 Neoplasms of the Exocrine Pancreas Robert A Wolff, MD, James L Abbruzzese, MD, and Douglas B Evans, MD
- Chapter 102 Neoplasms of the Small Intestine, Vermiform Appendix, and Peritoneum Erik Barquist, MD and Michael Zinner, MD
- Chapter 103 Adenocarcinoma of the Colon and Rectum Howard W Bruckner, MD, John Pitrelli, MD, and Marnin Merrick, MD
- Chapter 104 Neoplasms of the Anus Brenda Shank, MD, Warren E Enker, MD, and Marshall S Flam, MD
Section 30 Neoplasms of the Genitourinary Tract
- Chapter 105 Renal Cell Carcinoma Jerome P Richie, MD, Philip W Kantoff, MD, and Charles L Shapiro, MD
- Chapter 106 Neoplasms of the Renal Pelvis and Ureter Jerome P Richie, MD and Philip W Kantoff, MD
- Chapter 107 Bladder Cancer Philip W Kantoff, MD, Anthony L Zietman, MD, and Kenneth Wishnow, MD
- Chapter 108 Neoplasms of the Prostate William K OH, MD, Mark Hurwitz, MD, Anthony V D’Amico, MD, Jerome P Richie, MD, and Philip W Kantoff, MD
- Chapter 109 Neoplasms of the Penis Victor A Marcial, MD, A. Puras, MD, and V. A Marcial-Vega, MD
- Chapter 110 Neoplasms of the Testis Craig R Nichols, MD, Robert Timmerman, MD, Richard S Foster, MD, Bruce J Roth, MD, and Lawrence H Einhorn, MD
Section 31 Neoplasms of the Female Reproductive Organs
- Chapter 111 Neoplasms of the Vulva and Vagina Jacob Rotmensch, MD and Arthur L Herbst, MD
- Chapter 112 Neoplasms of the Cervix J. Taylor Wharton, MD and Guillermo Tortolero-Luna, MD
- Chapter 113 Endometrial Cancer Carmel J Cohen, MD, Gillian M Thomas, MD, and George S Hagopian, MD
- Chapter 114 Neoplasms of the Fallopian Tube Carmel J Cohen, MD, Gillian M Thomas, MD, and George S Hagopian, MD
- Chapter 115 Ovarian Cancer Jonathan S Berek, MD, Gillian M Thomas, MD, and Robert F Ozols, MD
- Chapter 116 Gestational Trophoblastic Disease Ross S Berkowitz, MD and Donald P Goldstein, MD
- Chapter 117 Gynecologic Sarcomas Carmel J Cohen, MD, Gillian M Thomas, MD, and George S Hagopian, MD
Section 32 Neoplasms of the Breast
- Chapter 118 Neoplasms of the Breast Richard G Margolese, MD, Bernard Fisher, MD, Gabriel N Hortobagyi, MD, and William D Bloomer, MD
Section 33 Neoplasms of the Skin
- Chapter 119 Neoplasms of the Skin Thomas B Fitzpatrick, MD
Section 34 Malignant Melanoma
- Chapter 120 Malignant Melanoma Donald L Morton, MD, Richard Essner, MD, John M Kirkwood, MD, and Robert C Wollman, MD
Section 35 Neoplasms of the Bone and Soft Tissue
- Chapter 121 Bone Tumors Gerald Rosen, MD, Charles A Forscher, MD, Henry J Mankin, MD, and Michael T Selch, MD
- Chapter 122 Sarcomas of Nonosseous Tissues Peter W T Pisters, MD, Brian O’Sullivan, MD, and George D Demetri, MD
Section 36 Neoplasms of the Hematopoitic System
- Chapter 123 Myelodysplastic Syndrome Lewis R Silverman, MD
- Chapter 124 Acute Myeloid Leukemia in Adults Charles A Schiffer, MD and Richard M Stone, MD
- Chapter 125 Chronic Myeloid Leukemia Richard T Silver, MD
- Chapter 126 Acute Lymphocytic Leukemia in Adults Charles A Schiffer, MD and Richard A Larson, MD
- Chapter 127 Chronic Lymphocytic Leukemia Kanti R Rai, MD and Michael J Keating, MD
- Chapter 128 Hairy-Cell Leukemia Harvey M Golomb, MD and James Vardiman, MD
- Chapter 129 Hodgkin’s Disease Peter Mauch, MD and James O Armitage, MD
- Chapter 130 Non–Hodgkin’s Lymphomas Arnold S Freedman, MD and Lee M Nadler, MD
- Chapter 131 Mycosis Fungoides and the Sézary Syndrome Youn H Kim, MD and Richard T Hoppe, MD
- Chapter 132 Plasma Cell Tumors Kenneth C Anderson, MD
- Chapter 133 Mast Cell Leukemia and Other Mast Cell Neoplasms Richard M Stone, MD and Steven H Bernstein, MD
- Chapter 134 Polycythemia Vera and Essential Thrombocythemia Scott Murphy, MD
Section 37 Neoplasms in AIDS
- Chapter 135 Neoplasms in Acquired Immunodeficiency Syndrome David T Scadden, MD
Section 38 Neoplasms of Unknown Primary Site
- Chapter 136 Neoplasms of Unknown Primary Site John D Hainsworth, MD and F. Anthony Greco, MD
Section 39 Neoplasms in Children
- Chapter 137A Principles and Practice of Pediatric Oncology Michael A Weiner, MD
- Chapter 137B Incidence, Origins, Epidemiology Leslie L Robison, PhD
- Chapter 137C Principles of Pediatric Radiation Oncology John C Breneman, MD and Ashwatha Narayana, MD
- Chapter 137D Late Effects of Treatment of Cancer in Children and Adolescents Daniel M Green, MD
- Chapter 138A Childhood Acute Lymphoblastic Leukemia Paul S Gaynon, MD, Michael E Trigg, MD, and Fatih M Uckun, MD
- Chapter 138B Pediatric Acute Myeloid Leukemia Richard Aplenc, MD and Beverly Lange, MD
- Chapter 138C Hodgkin’s Disease in Children and Adolescents Allen Chauvenet, MD, Cindy L Schwartz, MD, and Michael A Weiner, MD
- Chapter 138D Non-Hodgkin’s Lymphoma in Children Mitchell S Cairo, MD and Sherrie Perkins, MD
- Chapter 138E Langerhans’ Cell Histiocytosis Kara M Kelly, MD
  - The Histiocytic Disorders
  - References
- Chapter 139A Hepatic Tumors Marcio Henrique Malogolowkin, MD
- Chapter 139B Renal Tumors of Childhood Paul E Grundy, MD, Daniel M Green, MD, Norman E Breslow, PhD, Michael L Ritchey, MD, and Patrick R M Thomas, MB
- Chapter 139C Germ Cell Tumors Barbara Cushing, MD and Neyssa Marina, MD
- Chapter 139D Neuroblastoma Katherine K Matthay, MD and Darrell J Yamashiro, MD
- Chapter 139E Soft Tissue Sarcomas of Childhood Leonard H Wexler, MD and Lee J Helman, MD
Section 40 Complications of Cancer and its treatment
- Chapter 140 Management of Cancer Pain Alan C Carver, MD and Kathleen M Foley, MD
- Chapter 141 Anorexia and Cachexia Takao Ohnuma, MD
- Chapter 142 Antiemetic Therapy Richard J Gralla, MD
- Chapter 143 Neurologic Complications Lisa M DeAngelis, MD and Jerome B Posner, MD
- Chapter 144 Dermatologic Complications of Cancer Chemotherapy Narin Apisarnthanarax, MD and Madeleine Duvic, MD
- Chapter 145 Skeletal Complications Samuel Kenan, MD and Gabriel N Hortobagyi, MD
- Chapter 146 Hematologic Complications and Blood Bank Support Kenneth C Anderson, MD
- Chapter 147 Coagulopathic Complications of Cancer Sabine Eichinger, MD and Kenneth A Bauer, MD
- Chapter 148 Urologic Complications Christopher J Logothetis, MD and Jose E Sarriera, MD
- Chapter 149 Cardiac Complications Michael S Ewer, MD and Robert S Benjamin, MD
- Chapter 150 Respiratory Complications Roy B Jones, PhD
- Chapter 151 Liver Function and Hepatotoxicity in Cancer Laurie D DeLeve, MD
- Chapter 152 Gastrointestinal Complications Frank A Sinicrope, MD and Bernard Levin, MD
- Chapter 153 Oral Complications Stephen T Sonis, DMD
- Chapter 154 Gonadal Complications Catherine E Klein, MD
- Chapter 155 Endocrine Complications S. Jim Yeung, MD and Robert F Gagel, MD
- Chapter 156 Secondary Cancers: Incidence, Risk Factors, and Management Susan R Rheingold, MD, Alfred I Neugut, MD, and Anna T Meadows, MD
Section 41 Infections in Patients with Cancer
- Chapter 157 Infections in Patients with Cancer Kenneth V I Rolston, MD and Gerald P Bodey, MD
Section 42 Oncologic Emergencies
- Chapter 158 Oncologic Emergencies John C Morris, MD and James F Holland, MD
Section 43 Oncology and the Information Revolution
- Chapter 159 Oncology and the Information Revolution Edward P Ambinder, MD

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