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C. elegans II

2nd

RiddleDonald L

BlumenthalThomas

MeyerBarbara J

PriessJames R

1University of Missouri, Columbia

2Indiana University

3University of California, Berkeley

4Howard Hughes Medical InstituteFred Hutchinson Cancer Research Center, Seattle

Cold Spring Harbor Laboratory Press0-87969-532-31997

molecular biologydevelopmental biology

Book Information
COLD SPRING HARBOR MONOGRAPH SERIES
Reviewers
Preface
Foreword
Chapter 1 Introduction to C. elegans Donald L Riddle, Thomas Blumenthal, Barbara J Meyer, and James R Priess
- I The Biological Model
- II Origins of the Model
- III Life History And Evolution
- IV Anatomy
- V Resources
- VI Current Issues
- Acknowledgments
Chapter 2 The Genome Robert H Waterston, John E Sulston, and Alan R Coulson
- I General Properties
- II The Physical Map
- III Genetics, Genes, and the Physical Map
- IV Genome Sequencing
- V EST Sequencing
- VI Interpretation of the Sequence
- VII Tentative Conclusions
- VIII Prospects
- Acknowledgments
Chapter 3 Chromosome Organization, Mitosis, and Meiosis Donna G Albertson, Ann M Rose, and Anne M Villeneuve
- I Introduction
- II Mitosis
- III Meiosis
- IV Prospects
Chapter 4 Mutation Robert C Johnsen and David L Baillie
- I Introduction
- II Induced Mutations
- III Genetic Balancers
- IV Genetically Detectable Genes
- V What are Essential Genes?
- VI Gene Distribution
- VII Summary
- Acknowledgment
Chapter 5 Transposons Ronald H A Plasterk and Henri G A M van Luenen
- I Introduction
- II Tc1 and Tc3
- III Other Elements
- IV The Tc1/mariner Family
- V Regulation of Tc1/mariner Transposition
- VI Mechanism of Tc1 Transposition
- VII Repair After Tc1 Excision
- VIII Tc1 as a Tool in C. elegans Research
- Acknowledgments
Chapter 6 RNA Processing and Gene Structure Thomas Blumenthal and Keith Steward
- I Introduction
- II Cis -Splicing in Worms
- III Trans -Splicing
- IV SL2 Trans -Splicing and Operons
- V Trans -Splicing in Vitro
- VI Frequency of Operons and Trans -Splicing
- VII Organization and Transcription of Spliced Leader RNA Genes
- VIII 3′-End Formation
- IX Translation Initiation and Termination Signals
- X Conclusions
- Acknowledgments
Chapter 7 Transcription Factors and Transcriptional Regulation James D McGhee and Michael W. Krause
- I Introduction
- II The Basal Transcription Machinery
- III Transcription Factors
- IV Analysis of C. elegans Promoters
- V Future Prospects
Chapter 8 mRNA and Translation Philip Anderson and Judith Kimble
- I Introduction
- II The Translational Apparatus
- III Informational Suppressors
- IV Regulation of Translation During Development
- Acknowledgments
Chapter 9 Sex Determination and X Chromosome Dosage Compensation Barbara J Meyer
- I Introduction
- II Sexual Dimorphism
- III The Primary Sex-Determination Signal and its Gene Target
- IV Hermaphrodite-Specific Genes that Coordinately Control Sex Determination and Dosage Compensation
- V X Chromosome Dosage Compensation
- VI Somatic Sex Determination
- VII Sex Determination in The Germ Line Versus the Soma
- VIII Concluding Remarks
- Acknowledgments
Chapter 10 Developmental Genetics of the Germ Line Tim Schedl
- I Introduction
- II Summary of Anatomy and Development of the Germ Line
- III Genetic Analysis of Germ-Line Development
- IV Somatic Gonad
- V Germ-Line Specification and Survival
- VI Germ-Line Sex Determination
- VII Control of Proliferation and Entry into the Meiotic Pathway
- VIII Meiotic Prophase Progression and Gametogenesis
- IX Oocyte Development, Maturation, and Ovulation
- X Future Prospects
- Acknowledgments
Chapter 11 Spermatogenesis Steven W L'Hernault
- I Overview
- II Organelle Morphogenesis During Spermatogenesis
- III Spermiogenesis
- IV Acquisition and Mechanism of Spermatozoan Motility
- V Role of Motility During Oocyte Recognition
- VI Future Prospects
- Acknowledgments
Chapter 12 Male Development and Mating Behavior Scott W Emmons and Paul W Sternberg
- I Introduction and Overview of Male Anatomy
- II Behavior
- III Development
- IV Concluding Remarks
- Acknowledgments
Chapter 13 Fertilization and Establishment of Polarity in the Embryo Kenneth J Kemphues and Susan Strome
- I Introduction
- II Fertilization
- III Establishment of Polarity in the One-Cell Embryo
- IV Cell Division Patterns in the Early Embryo
- V Summary and Speculation
Chapter 14 Specification of Cell Fates in the Early Embryo Ralf Schnabel and James R Priess
- I Introduction
- II Specification of Cell Fates in the AB Lineage
- III Specification of the P₁ Descendants
- IV Future Prospects
Chapter 15 Cell Death Michael O Hengartner
- I Introduction
- II Programmed Cell Death in C. elegans
- III Genetics of Programmed Cell Death
- IV Programmed Cell Death in Specific Cell Types
- V Cell Deaths not Mediated by the Common Death Program
- VI Evolution of Programmed Cell Death
- Acknowledgments
Chapter 16 Muscle: Structure, Function, and Development Donald G Moerman and Andrew Fire
- I Introduction
- II The Organization, Structure, and Function of Muscle
- III Specification of Muscle Patterns: Programs for Muscle Determination and Differentiation
- Acknowledgments
Chapter 17 Extracellular Matrix James M Kramer
- I Introduction
- II Cuticle
- III Basement Membranes
- IV Conclusions
- Acknowledgments
Chapter 18 Heterochronic Genes Victor Ambros
- I Introduction
- II Heterochronic Phenotypes
- III Control of Larval Development by lin-14
- IV Developmental Programs and Regulatory Targets
- V Postdauer Reprogramming of Heterochronic Phenotypes
- VI Perspectives
- Acknowledgments
Chapter 19 Development of the Vulva Iva Greenwald
- I Introduction and Overview
- II The Anchor Cell
- III VPC Generation and Identity
- IV VPC Specification
- V Execution
- VI Morphogenesis
- VII Evolution of Vulval Development
- VIII Future Prospects
- Acknowledgments
Chapter 20 Patterning the Nervous System Gary Ruvkun
- I Introduction
- II Invariant Cell Lineages in C. elegans Neurogenesis
- III Specification of Sensory Neuronal Development
- IV Generation of Reiterated Neurons by Reiterated Cell Lineages
- V Spatial Patterning by the C. elegans HOM-C Gene Cluster
- VI Concluding Remarks
Chapter 21 Cell and Growth Cone Migrations Adam Antebi, Carolyn R Norris, Edward M Hedgecock, and Gian Garriga
- I Introduction
- II Neuroglia and Pioneers
- III Netrins Guide Circumferential Migrations
- IV Hierarchies Of Guidance Cues
- V Genetic Requirements for Axonal Growth
- VI Cell Migration and other Aspects of Cellular Phenotype
- VII Muscle Positioning on the Body Wall and Muscle Arm Chemotropism
- VIII Future Directions
- Acknowledgments
Chapter 22 Synaptic Transmission James B Rand and Michael L Nonet
- I Introduction
- II Neurotransmitter Metabolism and Function
- III Components Regulating Neurotransmitter Release in all Neurons
- IV Conclusions and Future Perspectives
- Acknowledgments
Chapter 23 Mechanotransduction Monica Driscoll and Joshua Kaplan
- I Introduction: the Neural Circuit For Locomotion
- II Mechanosensory Control of Locomotion
- III Touch Receptor Development and Differentiation
- IV Genes Required for Touch Receptor Function
- V Conclusions
- Acknowledgments
Chapter 24 Feeding and Defecation Leon Avery and James H Thomas
- I Introduction: Nematode Hydrostatics
- II Feeding
- III Defecation Motor Program
- IV Conclusions
- Acknowledgments
Chapter 25 Chemotaxis and Thermotaxis Cornelia I Bargmann and Ikue Mori
- I Introduction
- II C. elegans Responds to a Variety of Chemicals
- III The Behavioral Mechanism of Chemotaxis and Thermotaxis
- IV Cellular Analysis of Chemosensory and Thermosensory Neurons
- V Genetic and Molecular Analysis of Chemosensation and Thermosensation
- VI Regulation of Chemotaxis and Thermotaxis by Experience
- VII Conclusions and Prospects
- Acknowledgments
Chapter 26 Genetic and Environmental Regulation of Dauer Larva Development Donald L Riddle and Patrice S Albert
- I Introduction
- II The Dauer State
- III Developmental Transitions
- IV A Network of Gene Functions
- V Summary and Conclusions
- Acknowledgments
Chapter 27 Neural Plasticity Erik M Jorgensen and Catharine Rankin
- I Introduction: Connectivity and Plasticity
- II Synaptic Plasticity During Development
- III Behavioral Plasticity in the Adult
- IV Conclusions
- Acknowledgments
Chapter 28 Environmental Factors and Gene Activities That Influence Life Span Cynthia Kenyon
- I The Study of Life Span
- II Theories of Aging
- III Aging in C. elegans
- IV The Search for Genes that Control the Rate of Aging
- V Prospects
- Acknowledgments
Chapter 29 Evolution David H A Fitch and W. Kelley Thomas
- I Introduction
- II Phylogenetic Context for C. elegans
- III Character Evolution
- IV Other Directions
- V Conclusions
- Acknowledgments
Chapter 30 Parasitic Nematodes Mark Blaxter and David Bird
- I The Nematode World
- II An Introduction to Some Nematode Parasites
- III Antinematode Compounds and Their Targets
- IV The Nematode Surface
- V Parasite Genes and Genomes
- VI Future Prospects
- Acknowledgments
Appendix 1 Genetics Jonathan Hodgkin
- Part A Genetic Nomenclature
- Part B List of Laboratory Strain and Allele Designations
- Part C Skeleton Genetic Map
- Part D List of Characterized Genes
- Acknowledgments
- Gene List
Appendix 2 Neurotransmitter Assignments for Specific Neurons James B Rand and Michael L Nonet
Appendix 3 Codon Usage in C. elegans Paul M Sharp and Keith R Bradnam
Appendix 4 On-line C. elegans Resources Mark L Edgley, Carolyn A Turner, and Donald L Riddle
- Part A ACeDB Resources
- Part B C. elegans Genome Project and Related Sources
- Part C Other Information Sources
Bibliography

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